1995 Fiscal Year Final Research Report Summary
Regulatory mechanism of dopamine metabolism in rat brain.
| Project/Area Number |
05670801
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY |
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Principal Investigator |
KURACHI Masayoshi Toyama Medical and Pharmaceutical University Depart. of Neuropsychiatry, Prof., 医学部, 教授 (80019603)
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| Co-Investigator(Kenkyū-buntansha) |
SHIBATA Ryoko Toyama Medical and Pharmaceutical University Dept. of Neuropsychiatry, Assistant, 医学部, 助手 (40216023)
TANII Yasuyuki Toyama Medical and Pharmaceutical University Dept. of Neuropsychiatry, Assistant, 付属病院, 講師 (80227206)
SUZUKI Michio Toyama Medical and Pharmaceutical University Dept. of Neuropsychiatry, Assistant, 付属病院, 講師 (40236013)
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| Project Period (FY) |
1993 – 1995
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| Keywords | dopamine metabolism / entorhinal cortex / amygdala / schizophrenia |
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| Research Abstract |
1.Changes in concentrations of dopamine (DA) and its metabolites (DOPAC and HVA) follwing haloperidol decanoate administration in rat were investigated. The results showed that the initial increase in HVA on day 1 had significantly attenuated as early as day 3 and diminished further on day 11 almost in parallel in the frontal cortex, caudate-putamen, and amygdala.
2.(1) Concentration of DA and its metabolites following the left entorhinal cortex lesion in rat brain were datermined and (2) The effects of acute administration of methamphetamine on DA release in the left amygdala in lesioned rats was measured by the in vivo microdialysis method. The results showed that (1) the only change on the 28th postoperative day was the increased concentration of DA in the lateral amygdala compared with the controls. (2) The DA release in the left amygdala in the lesioned rats was significantly higher than that in the controls. These results suggest that the entorhinal cortex lesioned rats may be useful for an animal model to study DA overactivity in schizophrenia.
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