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1994 Fiscal Year Final Research Report Summary

The regulation of gene expression for the genes associated with eosinophils.

Research Project

Project/Area Number 05670927
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Hematology
Research InstitutionJichi Medical School

Principal Investigator

YAMAGUCHI Yuji  Jichi Medical School, Lecturer, 医学部, 講師 (00220286)

Co-Investigator(Kenkyū-buntansha) KASAHARA Tadashi  Jichi Medical School, Lecturer, 医学部, 助教授 (60049096)
Project Period (FY) 1993 – 1994
KeywordsGATA-1 / eosinophil / Eosinophil peroxidase / Charcot-Leyden crystal / Transcription factor
Research Abstract

The analysis of the regulation of gene expression for the genes associated with eosinophils were caried out.
1.GATA-1 plays an important role in the eosinophil defferentiation of eosinophilic cell line, HL-60-C15 cells, and normal human bone marron cells.
2.In the promoter for the gene encoding human eosinophil peroxidase, a number of positively and negatively acting elements were identified.
3.The regulatory regions of Charcot-Leyden crystal protein were identified.

  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] Yuji Yamaguchi: "Functional Characterization of the Promoter for the Gene Encoding Human Eosinophil Peroxidase" J.Biol Chem.269. 19410-19419 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Gomolin, H.I., Yamaguchi, Y., Palupillai, A.V., Dvorak, L.A., Ackerman, S.J., Tenen, D.G.: "Human eosinophil Charcot-Leyden crystal protein : Cloning and characterization of a lyso phospholipase gene promoter." Blood. 82. 1868-1874 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Zon, L.I., Yamaguchi, Y., Yee, K., Albee, E.A., Kimura, A., Bennett, J.C., Orkin, S.H., Ackerman, S.J.: "Expresion of mRNA for the GATA-binding proteins in human eosinophils and basophils : Potential role in gene transcription." Blood. 81. 3234-3241 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamaguchi, Y., Zhang, D.E., Sun, Z., Albee, E.A., Nagata, S., Tenen, D.G., Ackerman, S.J.: "Functional characterization of the promoter for the gene encoding human eosinophil peroxidase." J.Biol.Chem.269. 19410-19419 (1994)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1996-04-15  

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