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1994 Fiscal Year Final Research Report Summary

A study on new diagnosis and treatment by receptorscintigraphy for neuroendocrine tumor

Research Project

Project/Area Number 05671027
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionTeikyo University

Principal Investigator

TAKAMI Hiroshi  Teikyo Univ.Sch Med Professor, 医学部, 教授 (10146714)

Co-Investigator(Kenkyū-buntansha) TANATANI Yuuji  Teikyo Univ.Sch Med Assist Professor, 医学部, 講師 (20129604)
MIURA Seishi  Teikyo Univ.Sch Med Assist Professor, 医学部, 助教授 (00165961)
KODAIRA Susumu  Teikyo Univ.Sch Med Professor, 医学部, 教授 (00110015)
Project Period (FY) 1993 – 1995
Keywordsneuroendocrine tumor / carcinoid / somatostatin receptor / receptor scintigraph
Research Abstract

1.Receptorscintigraphy in nudemouse
1) Scentigraphy was performed employing 125I- (Tyr11) SRIF.Content of Somatostatin in human neuroendocrine tumors was positive in one case of carcinoid of transverse colon among 3 cases of medullary thyroid carcinoma and 2 cases of carcinoids. Radioligand showed (125I) LTT-SRIF-28 adn IC50 was o.31 nmol/L.
2) The nude mouse used was BALB/c (6 w/o), male and 16-20g at wight. The experiments were started form 23 days after inoculation. The insulinoma which showed positive somatostatin receptor and were gifted revealed positive accumulation of 125I- (Tyr) SRIF at tumor itself. At the first day after inoculation, sotope was trapped into liver and thyroid, but at third day specificity of scintigraphy was increased. Therefore, this scintigraphic system was thought to be meaningful.

  • Research Products

    (2 results)

All Other

All Publications (2 results)

  • [Publications] 高見 博: "消化管ホルモン産生腫瘍に対する内分泌療法" KARKINOS. 7. 63-66 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiroshi Takami: "Endocrine therapy for hormone producing tumor of the alimentary tract" KARKINOS. 7. 63-66 (1994)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1996-04-15  

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