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1995 Fiscal Year Final Research Report Summary

Preoperative assessment for malignant behavior of upper gastrointestinal tract

Research Project

Project/Area Number 05671076
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionKAGOSHIMA UNIVERSITY

Principal Investigator

AIKOU Takashi  Kagoshima University Faculty of Medicine Professor, 医学部, 教授 (60117471)

Co-Investigator(Kenkyū-buntansha) BABA Masamichi  Kagoshima University University Hospital Assistant Professor, 医学部附属病院, 講師 (60198950)
TANABE Gen  Kagoshima University University Hospital Research Associate, 医学部附属病院, 助手 (60207157)
NATSUGOE Shoji  Kagoshima University University Hospital Research Associate, 医学部附属病院, 助手 (70237577)
Project Period (FY) 1993 – 1995
KeywordsCarcinoma of the upper gastrointestinal tract / Malignant behavior of the carcinoma / Metastasis / Cell adhesion molecle / Desmosome
Research Abstract

Desmosomes are intercellular junctions which play an important role in epithelial cell adhesion. We reported a decrease in number of desmosomes in esophageal cancer cells as shown by electron microscopic study. Desmoglein I (DGI) is a major component of the desmosomal membrane core that plays an important role in epitherial cell adhesion. Normal squamous epitherial cells strongly expressed DGI at their cell-cell boundaries. According to the intensity and pattern of DGI expression, the cancerous tissues were divided into three groups : DGI (++), DGI (+), and DGI (-). DGI (+) or DGI (-) tumors had lymph node metastases more frequently than DGI (++). A good inverse correlation between DGI expression and tumor invasion, lymph node metastasis, lymphatic invasion and vessel invasion was observed. DGI expression in metastatic lymph nodes was the same or of less intensity, than in the primary tumor. Therefore, reduction or loss of DGI expression may promote lymph node metastases. Thorombomodul … More in (TM) is thorombin receptor that identified originally on the endothelium and acts a natural anticoagulant. TM was immunohistochemically expressed in the squamous epithelium mainly at the intercellular bridges. The carcinoma tissues expressed TM mainly at the cell-cell boundaries and in the cytoplasm. When TM expression was compared between the primary and metastatic lesions, TM expression was far fewer in the metastatic lesions than in the primary tumors. The reduction of TM expression seems to play an important role in the metastatic process.
In the patinets with gastric carcinoma, a down-regulation of DGI expression and lymph node metastasis, lymphatic invasion and the number of lymph node metastasis. A close relationship between DGI expression and lymph node metastasis was found, compared with C-erbB2, p53, FH6 and PCNA.Furthermore, survival rate of patients with HLA-DR positive cells or with many S-100 protein positive dendritic cells was significantly better than that of the other patients.
These results may provide us with some important infomations for malignant behavior of the upper gastrointestinal tract. Less

  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] Shoji Natsugoe: "Expression of desmoglein I cell adhesion molecule in primary tumors and metastatic lynph nodes of esophageal cancer." International Journal of Oncology. 6. 345-348 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshihisa Tezuka: "Expression of Thrombomdulin in Esophageal squamoius cell carcinoma and Its Rehtionship to lynsh Nade Netastasis" Cancer Research. 55. 4196-4200 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 愛甲 孝: "癌転移の分子機序と転移の臨床予測診断法の進歩" 日本臨床. 53. 1571-1577 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masamichi Baba: "Lymph nade metastasis and the recurrence of esophageal careincma with emphasis on lynphadenectyomy in the neak and superior mediastrobum." Surgery Today. 25. 125-130 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 愛甲 孝: "胃癌に対するリンパ節郭清の縮小化と拡大化の現況と今後の展望" 日本消化器外科学会雑誌. 27. 968-973 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takashi Aikou: "A comparative study on fine structure of inflammatory and neoplastic dysplasia of the esophagus." Medical Electoron Migroscopy. 26. 89-97 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shoji Natsugoe: "International gastric cancer congress" M. Nishi, H.Sugano, T.Takahashi, 5 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takashi Aikou: "Recent Advances in Management of Digestive" T.Takahashi, 3 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takashi Aikou, Shoji Natsugoe, Mario Shimada, Hisaaki Shimazu: "A comparative study on fine structure of inflammatory neoplastic dysplasia of the esophagus." Med.Electron Microsc.26. 89-97 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masamichi Baba, Takashi Aikou, Heiji Yoshinaka, Shoji Natsugoe, Toshitaka Fukumoto, Hisaaki Shimazu, Kouhei Akazawa: "Long-term results of subtotal esophagectomy with three-field lymphadenectomy for carcinoma of the esophagus." Annuls of Surgery. 219. 310-316 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shoji Natsugoe, Takashi Aikou, Mario Shimada, Toru Kumanohoso, Yoshihisa Tezuka, Mituhisa Sagara, , Heiji Yoshinaka, Masamichi Baba, Toshitaka Fukumoto: "Expression desmoglein I in squamous cell carcinoma of the esophagus." Journal of Surgical Oncology. 57. 105-110 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shoji Natsugoe, Takashi Aikou, Mario Shimada, Heiji Yoshinaka, Hisaaki Shimazu, Hirohumi Matsushita: "Occult lymph node metastasis in gastric cancer with submucosal invasion." Surgery Today. 24. 870-875 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masamichi Baba, Shoji Natsugoe, Chikara Kusano, Kazusada Shirao, Shirao, Soji Sane, Toru Kumanohoso, Heiji Yoshinaka, Toshitaka Fukumoto, Takashi Aikou: "Lymph node metastasis and the recurrence of esophageal carcinoma with emphasis on lymphadenectomy in the neck and superior mediastinum." Surgery Today. 25. 125-130 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shoji Natsugoe, Mituhisa Sagara, Mario Shimada, Toru Kumanohoso, Shimada, Toru Kumanohoso, Kazunobu Tokuda, Daisuke Wakamatus, Yoshihisa Tezuka, Chikara Kusano, Heiji Yoshinaka, Masamichi Baba, Toshitaka Fukumoto, Takashi Aikou: "Expression of desmoglein I cell adhesion molecule in primary tumors and metastatic lymph nodes of esophageal cancer" International Journal of Oncology. 6. 345-348 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshihisa Tezuka, Suguru Yonezawa, Ikuro Maruyama, Yoshihumi Matsushita, Takeshi Shimizu, Hiroya Obama, Mistuhisa Sagara, Kazusada Shirao, Chikara Kusano, Shoji Natsugoe, Heiji Yoshinaka, Masamichi, Baba, Toshitaka Fukumoto, Takashi Aikou, Eiichi Sato: "Expression of thorombomodulin in esophageal squamous cell carcinoma carcinoma and its relationship to lymph node metastasis" Cancer Research. 55. 4196-4200

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1997-03-04  

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