1994 Fiscal Year Final Research Report Summary

Effects of the continuous warm cardioplegic coronary perfusion on the postischemic myocardial function

Research Project

Project/Area Number	05671120
Research Category	Grant-in-Aid for General Scientific Research (C)
Allocation Type	Single-year Grants
Research Field	Thoracic surgery
Research Institution	Tottori University
Principal Investigator	MORI Tohru Tottori University Faculty of Medicine, Professor, 医学部, 教授 (80028498)
Co-Investigator(Kenkyū-buntansha)	KURODA Hiroaki Tottori University Faculty of Medicine, Assistant Professor, 医学部, 講師 (70186550)
Project Period (FY)	1993 – 1994
Keywords	continuous warm cardioplegia / calcium / magnesium
Research Abstract	The cardioprotective effect of the calcium and magnesium content of continuous warm hyperkalemic cardioplegic solutions (CWCP) was investigated using isolated rat hearts. 1. The maximum recovery of postischemic myocardial function was observed in hearts with a calcium concentration of 1.0mM regardless of magnesium concentrations. 2. The recovery of postischemic myocardial function decreased in hearts with calcium concentrations of 0.5mM or less as magnesium concentration increased. 3. The creatine kinase leakage in CWCP increased in hearts with calcium of 0.5mM or less as magnesium increased. These results suggest that the myocardial protective effects with the continuous warm cardioplegia depend on the relationship of calcium and magnesium concentration, which are different from the effects observed with ischemic state.

(5 results)