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1995 Fiscal Year Final Research Report Summary

Study on the abnormal expression of cytokine and growth factor genes in human malingnant gliomas.

Research Project

Project/Area Number 05671143
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

HOUKIN Kiyohiro  Hokkaido Univ. Hosp., Lecturer, 医学部附属病院, 講師 (90229146)

Co-Investigator(Kenkyū-buntansha) TADA Mitsuhiro  Hokkaido Univ. Hosp., 医学部附属病院, 医員
SAWAMURA Yutaka  Hokkaido Univ. Hosp., Lecturer, 医学部附属病院, 講師 (10235476)
Project Period (FY) 1993 – 1995
KeywordsMalignent glioma / Cytokine / Growth factor / Gene expression / Recepter / Neoplasms / Brain / Human
Research Abstract

This project has yielded a considerable amount of resutls. We found that malignant astrocytoma (glioma) cells produce interleukin-8 (IL-8), especially in 77-amino acid form (Tada M,et al., J Neuro-Oncol 15 : 25) Also we found that tumor necrosis factor-alpha stimulates glioma cells to produce various factors such as IL-6, IL-8, Mn-superoxide dismutase, and IL-1 (Sawamura Y,et al., J Neuro-Oncol 15 : 197) We have reported that glioma cells produce granulocyte-macrophage colony-stimutating factor (Sawamura Y,et al., Neurol Med Chir 33 : 603), monocyte chemoattractant protein-1 (Tada M,et al., Int J Cancer 58 : 240), interleukin-1 receptor antagonist (Tada M,et al., J Neuroimmunol 50 : 187). One of the investigator (M.T.) reviewed the cytokine production by glioma cells (Tada M,et al., J Neuro-Oncol 17 : 261) These cytokines and growth factors are detected in cerebrospinal fluid of patients with glioma, and considered to be useful for diagnosis of the disease (Sawamura Y,et al. Neuroimmunol Res 8 : 204). Concerning receptors for these cytokines and growth factors, we analyzed with RT-PCR method and found that glioma cells express IL-1 receptor type I,type2 ; p55, p75 TNF receptor ; interferon alpha/beta, gamma receptor, GM-CSF receptor, M-CSF receptor, SCF receptor, and IL-8 receptor (Tada M,et al., J Neurosurg 80 : 1063 ; Sawamura Y,et al., Neurol Med Chir 35 : 567)

  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] Tada M,: "Human astroglial cells produse 77-amino acid from interleukin-8 (IL-877)." Journal of Neuro-Oncology. 15. 25-34 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sawamura Y: "Responses of human glioblastoma cells to human natural tumor necrosis factor-α : susceptibility, mechanism of resistance and cytokine production studies." J Neuro-Oncol. 15. 197-208 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tada M: "Recent advances in immunobiology of brain tumors." J Neuro-Oncol. 17. 261-271 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sawamura Y: "Antiproliterative effect of tumor necrosis factor on human glioblastoma cells linked with cell arrest in G1 phase." Neurol Med Chir. 34. 274-278 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sawamura Y: "Human glioblastoma cells produce granulocyte-macrophage colony-stimulating factor in vitro, but not in vivo, without expressing its receptor." Neurol Med Chir. 33. 603-609 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tada M: "Analysis of cytokine receptor mRNA expressions in human glioblastoma cells cells and normal astrocytes by reverse-transcriotion polymerase chain reaction." J Neurosurg. 80. 1063-1073 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tada M: "Human astrocytomas and glioblastomas express monocyte chemoattractant protein-1 (MCP-1) in vivo and in vitro." Int J Cancer. 58. 240-247 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tada M: "Production of interleukin-1 receptor antagonist by human glioblastoma cells in vitro and in vivo." J Neuroimmunol. 50. 187-194 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sawamira Y: "p55 and p75 tumor necrosis factor receptor expression on human glioblastoma cells." Neurol Med Chir. 35. 567-574 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 沢村豊: "Glioma患者髄液中における増殖因子の検討." 神経免疫研究. 8. 204-211 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tada M,Sawamura Y,et al.: "Human astroglial cells produce 77-amino acid form interleukin-8 (IL-877)." J Neuo-Oncol. 15. 25-34 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sawamura Y,Tada M,et al.: "Responses of human glioblastoma cells to human natural tumor mecrosis factor-alpha-susceptibility, mechanism of resistance and cytokine production studies." J Neuro-Oncol. 15. 197-208 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tada M,et al.: "Recent advances in immunobiology of brain tumors." J Neuro-Oncol. 17. 261-271 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sawamura Y,Tada M,et al.: "Antiproliferative effect of tumor necrosis factor on human glioblastoma cells linked with cell cycle arrest in G1 phase." Neurol Med Chir. 34. 274-278 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sawamura Y,Tada M,et al.: "Human glioblastoma cells produce granulocyte-macrophage colony-stimulating factor in vitro, but not in vivo, without expressing its receptor." Neurol Med Chir. 33. 603-609 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tada M,et al.: "Analysis of cytokine receptor mRNA expressions in human glioblastoma cells cells and normal astrocytes by reverse-transcription polymerase chain reaction." J Neurosurg. 80. 1063-1073 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tada M,et al.: "Human astrocytomas and glioblastomas express monocyte chemoattractant protein-1 (MCP-1) in vivo and in vitro." Int J Cancer. 58. 240-247 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tada M,et al.: "Production of interleukin-1 receptor antagonist by human glioblastoma cells in vitro and in vivo." J Neuroimmunol. 50. 187-194 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sawamura Y,Tada M,et al.: "p55 and p75 tumor necrosis factor receptor expression on human glioblastoma cells." Neurol Med Chir. 35. 567-574 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sawamura Y,Tada M,et al.: "Analysis of growth factors in cerebrospinal fluid of patinets with glioma." Neuroimmunol Res. 8. 204-211 (1995)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1997-03-04  

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