1994 Fiscal Year Final Research Report Summary
Immunohistochemical and ultrastructural study on microcystic meningioma
| Project/Area Number |
05671180
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | University of Osaka Prefecture (1994)
Nara Medical University (1993) |
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Principal Investigator |
TSUNODA Shigeru College of Integrated Arts & Sciences, University of Osaka Prefecture Professor, 総合科学部, 教授 (60163862)
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| Project Period (FY) |
1993 – 1994
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| Keywords | microcystic meningioma / arachnoid trabecular cell |
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| Research Abstract |
The microcystic meningioma was first reported by Masson, who called it "meningioma humide". Later, Eimoto et al reported that the proliferation style of this type resembles the growth pattern of the subarachnoid space. Tsunoda et al proposed the view that the microcystic meningioma represents differentiation into arachnoid trabecular cells, on the grounds that the microcystic component resemble the arachnoid trabecular cells which support the normal sub-arachnoid space, as observed under an electron microscope.
In the present study, arachnoid trabecular cells were found to be GST-pi positive in the normal arachnoid villi and in microcystic meningiomas. It seems therefore likely that the arachnoid trabecular cells serve not only as supportive cells but also as cells which detoxify harmful substances in normal subarachnoid space.
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