1995 Fiscal Year Final Research Report Summary
Embryopathegenesis of cerebral dysgenesis and involvement of NGF in the neuronal maturation
| Project/Area Number |
05671187
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Tokai University School of Medicine |
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Principal Investigator |
OI Shizuo Tokai Univ.Sch.of Med., Neurosurgery, Assoc.Prof., 医学部・脳神経外科, 助教授 (30194062)
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| Co-Investigator(Kenkyū-buntansha) |
HONDA Yumie Tokai Univ.Sch.of Med., Neurosurgery, Assistant, 医学部・脳神経外科, 助手 (40266416)
HIDAKA Mitsugu Tokai Univ.Sch.of Med., Neurosurgery, Assistant, 医学部・脳神経外科, 助手 (90256123)
TANAKA Yoshimi Tokai Univ.Sch.of Med., Neurosurgery, Assistant, 医学部・脳神経外科, 助手 (20227193)
TAKEI Futoshi Tokai Univ.Sch.of Med., Neurosurgery, Assist.Prof., 医学部・脳神経外科, 講師 (00216839)
SATO Osamu Tokai Univ.Sch.of Med., Neurosurgery, Professor, 医学部・脳神経外科, 教授 (00023763)
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| Project Period (FY) |
1993 – 1995
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| Keywords | Nerve Growth Factor (NGF) / Fibroblastic Growth Factor (FGF) / Cholinergic Neuron / Neuronal Maturation / Dysraphic State / Spina Bifida / Experimental Mouse Model / Hippocampus |
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| Research Abstract |
The embryopathegenesis of dysraphic state has been extensive investigated in our previous laboratory experiments. The most striking findings revealed in the animal models of dysraphism, especially in "chick embryo myeloschisis or exencephaly models were the overmaturation of the neural placode. We have proposed a new hypothesis of pathogenesis of dysraphic state, namely "Overgrowth & Reopening" therapy.
The purpose of the research project in this period is to analyze the developmental process of nerve growth factor (NGF) along with the disturbed neuronal maturation process with "overgrowth" . The immunohistochemical technique was applied in the normal mouse and exencephalic mouse model. One of the NGF family (fibroblast growth factor : basic FGF) appeared in the hippocampus immediately after birth (This period is in the third trimester of the fetal life in human. The further investigation is now ongoing to compare the data from the dysraphic models.
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