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1994 Fiscal Year Final Research Report Summary

THE EFFECT OF ANESTHETICS ON CARDIO-VASCULAR INTERACTION

Research Project

Project/Area Number 05671269
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Anesthesiology/Resuscitation studies
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

HOKA Sumio  Kyushu University, Department of Anesthesiology, Lecturer, 医学部, 講師 (60150447)

Co-Investigator(Kenkyū-buntansha) KAWASAKI Toshihiro  Kyushu University, Department of Anesthesiology, Instructor, 医学部, 助手 (80253433)
OKAMOTO Hirotsugu  Kyushu University, Department of Anesthesiology, Instructor, 医学部, 助手 (50224077)
Project Period (FY) 1993 – 1994
Keywordsisoflurane / halothane / myocardial contractility / ventriculo-arterial coupling / Ea / Ees
Research Abstract

We compared the effects of two volatile anesthetics, halothane and isoflurane, on ventriculo-arterial coupling using an index of Ea/Ees. Ea and Ees represent arterial effective elastance and left ventricular end-systolic elastance, and are used as indices of cardiac afterload and cardiac contractility, respectively. Halothane 2MAC significantly decreased the cardiac output, Ea, and Ees by 35%, 18%, and 39%, respectively. Isoflurane 2MAC significantly decreased the cardiac output, Ea, and Ees by 37%, 38%, and 43%, respectively. Halothane increased Ea/Ees from 0.83 to 1.22, whereas isoflurane maintained the Ees/Es at a constant level. These results suggest that mechanical efficiency is well maintained during isoflurane anesthesia because it has an equivalent effect on left ventricular contractility and arterial properties, whereas halothane can impair mechanical efficiency by depressing left ventricular contractility more than the arterial system.
Our results also suggest that al-adrenoceptor stimulation is capable of reversing direct cardiac depressant effects of halothane, and that al-adrenoceptor stimulation may also be accompanied by a possible impairment of the oxygen supply-demand balance during halothane anesthesia.

  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] Kawasaki T.et al.: "The difference of isoflurane and halothane in ventriculo-arterial coupling in dogs." Anesth.Analg.79. 681-686 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hoka S.et al.: "Effects of phenylephrine and prostaglandin El on ventriculo-arterial matching during halothane anaesthesia." Br.J.Anaesth.74. 438-442 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hoka S.et al.: "The effects of isoflurane and sevoflurane on the left ventricular systolic pressure-volume relation in dogs." J.Anesth.9. 247-251 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Okuyama T.et al.: "Alphal-adrenoceptor stimulation is able to reverse halothane-induced cardiac depression in isolated rat hearts." Acta Anaesth.Scand.41. 939-944 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 外 須美夫, 他: "心室-血管系の相互関係に及ぼすPGE1の影響." 現代医療. 25. 2889-2896 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 外 須美夫: "心臓血管相互作用と麻酔." 麻酔. 44. S52-S58 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawasaki, T., Hoka, S., Okamoto, H., Okuyama, T., Takahashi, S.: "The difference of isoflurane and halothane in ventriculo-arterial coupling in dogs" Anesth.Analg.79. 681-686 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hoka, S., Kawasaki, T., Okamoto, H., Okuyama, T., Takahashi, S.: "Effects of phenylephrine and prostaglandin E1 on ventriculo-arterial matching during halothane anaesthesia" Br.J.Anaesth.74. 438-442 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hoka, S., Sato, M., Takahashi, S.: "The effects of isoflurane and sevoflurane on the left ventricular systolic pressure-volume relation in dogs" J.Anesth.9. 247-251 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hoka, S.: "Cardiovascular interaction and anesthesia" Masui. 44. S52-S58 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okuyama T., Hoka, S., Okamoto, H., Kawasaki, T., Yamaura, K., Takahashi, S.: "Alphal-adrenoceptor stimulation is able to reverse halothane-induced cardiac depression in isolated rat hearts" Acta Anaesth.Scand.41. 939-944 (1997)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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