Research of Beneficial Drugs in Perioperative Periods on Ischemic Heart Desiease.

1993 Fiscal Year Final Research Report Summary

• Project/Area Number: 05671276
• Research Category: Grant-in-Aid for General Scientific Research (C)
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Yokohama City University
• Principal Investigator: OKUMURA Fukuichiro Yokohama City University, School of Medicine, Professor, 医学部, 教授 (50028487)
• Co-Investigator(Kenkyū-buntansha): KUDOH Ichidai Yokohama City University, School of Medicine, Assistant Professor, 医学部, 助教授 (30145700) ; HAJIRI Etsurou Yokohama City University, School of Medicine, Assistant, 医学部, 助手 (30237953) ; SHIBATA Toshimitu Yokohama City University, School of Medicine, Assistant Professor, 医学部, 講師 (80106319)
• Project Period (FY): 1993 – 1995
• Keywords: Ischemic heart disease / Perioperative period / Phosphodiesterase III inhibitor / Langendorff preparation

Research Abstract

For the research of beneficial drugs to the patients who had ischemic heart disease, in perioperative periods, we studied the effects of Dopamine(DOA), Amrinone(AMR) and a novel Phosphodiesterase III inhibitor OPC18790(OPC) on left ventricular function and oxygen consumption in isolated low perfused guinea pig hearts. Coronary low perfusion decreases the left ventricular contratile performance and oxygen consumption. DOA2×10ィイD1-6ィエD1M, AMR 10ィイD1-4ィエD1M and OPC 10ィイD1-5ィエD1M increased the left ventricular pressure and dp/dt max, equally. But, percent OィイD22ィエD2 extraction was smaller in AMR and OPC than DOA. Increase of coronary perfusion flow was recognized in OPC and AMR, but not in DOA. These results indicate the benefit of the PDE III antagonist on ischemic heart in comparison with DOA.