1994 Fiscal Year Final Research Report Summary
GROWTH REGULATION AND MUTATION OF CHROMOSOME TREATED WITH STEROID HORMONS AND ANTICANCER DRUGS ON ENDOMETRIAL CANCER CELLS IN VITRO
| Project/Area Number |
05671394
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | IWATE MEDICAL UNIVERSITY |
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Principal Investigator |
IZUTSU Toshihiko IWATE MEDICAL UNIVERSITY.DEPARTMENT OF OBSTETRICS AND GYNECOLOGY.ASSOCIATE PROFFSSOR, 医学部, 助教授 (00103739)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUSHIMA Akimune IWATE MEDICAL UNIVERSITY.DEPARTMENT OF OBSTETRICS AND GYNECOLOGY.RESIDENT, 医学部, 助手 (20208937)
SATO Masayuki IWATE MEDICAL UNIVERSITY.DEPARTMENT OF OBSTETRICS AND GYNECOLOGY.RESIDENT, 医学部, 助手 (20183387)
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| Project Period (FY) |
1992 – 1994
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| Keywords | ENDOMETRIAL CANCER / CHROMOSOME / STEROID HORMONE |
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| Research Abstract |
I) Chromosomal analysis of endometrial cancer cells treated with steroid hormon
Endometrial cancer cell line (Ishikawa, HEC-1) were treated with 2x10^<-5>M Progesterone (P) and 2x10^<-5>M Danazol (D).
Ishikawa (IK) cell was not decreased treated with p or D.
HEC-1 (HEC) cell also was not decreased with P and D.
No chromosomal abnormalities were observed treated with Por D in IK or HEC.
II) chromosomal analysis of endometrial cancer cells treated with anticancer drug
Endometrial cancer cell line (IK) were treated with 5mug/ml CDDP (C) or 1x10^<-5>M Taxol (T).
Growth suppression (74%) was observed in IK cell after 24 hours exposure with C.
Growth suppression (62%) was observed in IK cell after 24 hours exposure with T.
HEC cell was not decreased after 4,8, or 24 hours exposure with C.
Growth suuppression (57%) was observed in IK cell after 4 hours exposure with T.
No chromosomal abnormalities were observed treated with T in IK or HEC.
chromosomal abnormalities such as gap, ctb, cte and csb were observed treated with C in IK or HEC.
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