1994 Fiscal Year Final Research Report Summary
Functional morphological analysis of pathogenesis of endolymphatic hydrops.
| Project/Area Number |
05671415
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Tohoku University |
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Principal Investigator |
HOZAWA Koji Tohoku Univ.School of Med.Assistant Professor, 医学部・附属病院, 講師 (20199459)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Katsuhisa Tohoku Univ.School of Med.Assistant Professor, 医学部・附属病院, 講師 (70159614)
INAMURA Naoki Tohoku Univ.School of Med.Assistant Professor, 医学部・附属病院, 講師 (20158760)
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| Project Period (FY) |
1993 – 1994
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| Keywords | Endolymphatic sac / Endolymphatic hydrops / Guiner pig / Modnoclonal antibody / Sympathetic nerve |
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| Research Abstract |
Sympathetic nerve supply was revealed in guinea prg endolymphatic sac at the first time. Sympathetic nerve fibers were delivered to endolymphatic sac through sigmord sinus and distributed mainly in intermediate and distal portrow. No fiber was found in endolymphatic duct. Sympathetic fibers were observed around blood vessels and below lning epitheltum, however, they never penetrated the basement membrane to enter epithelial layr.
Seven monoclonal antibodies were developed against endolynphatic sac of guinea prg. These monoclonal antibodies reacted with aptcal and laleral surface of epitheltal cells of intermediate and distal portion of endolymphatic sac. Some of these antibodies cross-reacted with distal urmany tubulus, indicating that the epitops may play some roles in absorbing water, elecholytes, and so on.
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