1994 Fiscal Year Final Research Report Summary
Induction of receptor elements in taste cells by specific innervation
| Project/Area Number |
05671560
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Asahi University |
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Principal Investigator |
NINOMIYA Y Sch.of Dentistry Assistant Prof., 歯学部, 助教授 (50076048)
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| Project Period (FY) |
1993 – 1994
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| Keywords | Cross-regeneration / Taste cell / Taste axon / Chorda tympani nerve / Glossopharyngeal nerve / Synaptic reformation / Reinnervation |
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| Research Abstract |
It is known that a sodium channel blocker, amiloride, inhibits NaCl responses of the mouse chorda tympani nerve, but not those of the glossopharyngeal nerve. In this study, to elucidate how amiloride-sensitivities of taste cells would be influenced by innervation of different taste axons, I examined amiloride inhibition of NaCl responses in cross-regenerated chorda tympani and glossopharyngeal fibers which were forced to innervate different regions of the tongue possessing originally different amiloride-sensitivities. The cross-regeneration of the mouse chorda tympani fibers induced amiloride-inhibitable receptor sensitivities on their forced-regenerated posterior tongue region, whereas that of the glossopharygeal fibers did not induce the amiloride-inhibitable sensitivities on the anterior tongue. This suggests that the induction of the specific sodium receptor element on cross-reinnervated mouse tongue requires selective synaptic reformations between regenerated taste cells and axons. This may play a key role on maintaining the stable sensory code for taste quality in the face of continual receptor cell turnover and possible taste cell-axon regeneration after the taste nerve injury.
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