1995 Fiscal Year Final Research Report Summary
Development of New Synthetic Methods based on Early Transition Metals
| Project/Area Number |
05671770
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | Tokyo College of Pharmacy |
|---|
Principal Investigator |
HANZAWA Yuji Tokyo College of Pharmacy, School of Pharmaceutical Science, Associate Professor, 薬学部, 助教授 (10096688)
|
|---|
| Project Period (FY) |
1993 – 1995
|
| Keywords | Early transition metal / Zirconocene-butene complex / Ring contraction / Steroidal side chains / Diastereoselective synthesis / Catalyst / Oxetanocin / Vinylcyclopropane |
|---|
| Research Abstract |
In our ongoing research project on organic syntheses using early transtition metals, zirconium, vanadium, niobium etc., we have exploited enormous possibilities of low valent zirconium complex, zirconocene-butene complex, for organic synthesis. During the past term of project we established an efficient method for the preparation of optically pure carbocycles by treating vinyl sugar derivatives with zirconocene-butene complex and an application to the synthesis of bioactive molecules. We also established the construction of steroidal side chain based on the reaction of zirconocene with vinylcyclopropane, and we have also studied a short-step construction of steroidal skeleton based on the reaction of zirconocene and alkoxymethylated stirene derivatives.
|
