1994 Fiscal Year Final Research Report Summary
Evaluation of the effects of air pollutants on allergic responses
| Project/Area Number |
05680470
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
環境影響評価(含放射線生物学)
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| Research Institution | National Institute for Environmental Studies |
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Principal Investigator |
FUJIMAKI Hidekazu Environmental Health Sciences Division Section head, 環境健康部, 室長 (00124355)
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| Project Period (FY) |
1993 – 1994
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| Keywords | Allergy / Air pollution / DEP / NO_2 / Interleukin-4 / IL-4 |
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| Research Abstract |
To clarify the relationship between air pollutants and enduction of allergic diseases, studies on the effects of diesel exhaust particulates (DEP) and on the effects of No_2 exposure were performed. First, intratracheal or intranasal instillation with DEP and antigen induced enhanced antigen specific IgE antibody production in mice. The levels of interleukin-4 production from local lymph node cells were significantly increased. On the contrary, the levels of interferon-gamma were decreased compared with those of control mice. Second, guinea pigs and rats were exposed to low concentrations of NO_2 for 3 months and lung mast cells were isolated by the methods of enzymatic digestion. Although lung mast cells in NO_2 exposed rats did not increase IgE-mediated histamine release, lung mast cells in NO_2 exposed guinea pigs significantly increased the histamine release. These things suggest that air pollutants such as DEP and NO_2 may affect the activities of lymphocytes and mast cells involved in allergic responses.
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