1994 Fiscal Year Final Research Report Summary
Synaptic structure of amino acid neurons in the autonomic nuclei of the spinal cord
| Project/Area Number |
05680650
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Chiba University |
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Principal Investigator |
CHIBA Tanemichi Chiba University School of Medicine, Department of Anatomy, Professor, 医学部, 教授 (20009525)
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| Project Period (FY) |
1993 – 1994
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| Keywords | glutamic acid / glutaminase / intermedio-lateral nucleus / Nitric oxide / synapse / GABA / glycine / Chorela toxin subunit B |
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| Research Abstract |
1) A dense phosphate activated glutaminase-immunoreactive (PAG-ir) nerve terminals were observed in the intermediolateral nucleus of thoracic spinal cord of the rat.
2) Axon varicosities of PAG-ir nerves formed asymmetric synapses and contained small clear synaptic vesicles and large dense core synaptic vesicles. They formed mainly axo-dendritic synapses.
3) Density of PAG-ir nerve terminals was one of the highest among amine, peptide and amino acid nerves in the intermediolateral nucleus examined so far.
4) Glutamic acid nerves formed direct synaptic contacts to preganglionic sympathetic neurons which project to the superior cervical ganglia.
5) PAG-ir was detected in the cytoplasm of astroglia adjacent to the glutaminergic synapses.
6) GABA and glycine coexist in sub population of GABA neurons.
Nitric oxide nerves were distributed densely in the intermediolateral nucleus and other preganglionic sympathetic neurons of the spinal cord.
8) Amino acid nerve terminals are closely associated with NO neurons in the sympathetic preganglionic nuclei.
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[Publications] Hanazawa,T.,Motosugi,H.,Konno,A.,Kaneko,T.,and Chiba,T.: "Distribution of NADPH diaphorase positive nerve fibers in the rat nasal mucosa." Neurosc.Lett.,. 159. 71-74 (1993)
Description
「研究成果報告書概要(和文)」より
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[Publications] Inokuchi,H.,Masuko,S.,Chiba,T.,Yoshimura,M.,Polosa,C.and Nishi,S.: "Membrane properties and dendritic arborization of the intermediolateral nucleus neurons in the guinea-pig thoracic spinal cord in vitro." J.Auton.Nerv.Syst.,. 43. 97-106 (1993)
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「研究成果報告書概要(和文)」より
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[Publications] Hanazawa,T.,Konno,A.,Kaneko,T.,Tanaka,K.,Ohsima,H.,Esumi,H.,Chiba,T.: "Nitric oxide synthase-immunoreactive nerve fibers in the nasal mucosa of the rat." Brain Res.657. 7-13 (1994)
Description
「研究成果報告書概要(和文)」より
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[Publications] Inokuchi, H., Masuko, S., Chiba, T., Yoshimura, M., Polosa, C.and Nishi, S.: "Membrane properties and dendritic arborization of the intermediolateral nucleus neurons in the guinea-pig thoracic spinal cord in vitro." J.Auton.Nerv.Syst.43. 97-106 (1993)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Hanazawa, T., Konno, A., Kaneko, T., Tanaka, K., Ohshima, H., Esumi, H., Esumi, H., Chiba, T.: "Nitric oxide synthase-immunoreactive nerve fibers in the nasal mucosa of the rat." Brain Res.657. 7-13 (1994)
Description
「研究成果報告書概要(欧文)」より
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