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1994 Fiscal Year Final Research Report Summary

Studies on central nervous mechanisms of vocalization in monkeys

Research Project

Project/Area Number 05680718
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 神経・脳内生理学
Research InstitutionKansai Medical University

Principal Investigator

GEMBA Hisae  Kansai Medical University, Faculty of Medicine, Professor, 医学部, 教授 (00108987)

Project Period (FY) 1993 – 1994
KeywordsSelf-paced vocalization / Monkey / Cortical field potential / Emotion / Audio-initiated vocalization / Hemicerebellectomy / Voluntary movement / Readiness potential
Research Abstract

Field potentials were recorded with electrodes chronically implanted on the surface and at 2.0-3.0mm depth in various cortical areas in monkeys trained for vocalizing at self-pace (self-paced vocalization). In three monkeys, surface-negative, depth-positive (s-N,d-P) slow potentials prior to vocalization were led from the premotor, motor and somatosensory cortices and supplementary motor area in both hemispheres. Such premovement potentials were recorded also in the cingulate and prefrontal cortices when a monkey vocalized with strong motivation for reward. Cerebellar hemispherectomy on the right side eliminated the s-N,d-P premovement potentials in the motor cortex and in the posterior bank of the inferior limb of the arcuate sulcus (Broca's homologue) in the left hemisphere. After the operation, the tone came to have less components of different frequencies, and its duration varied much more than before. These facts suggest that the neocortical area homologous to the human speech are … More a takes part in the generation and control of monkey vocalization together with the cerebellum possibly through cerebro-cerebellar interactions. This is against ideas so far proposed on nonhuman primate vocalization, i.e., it is generally considered that animal vocalization differs fundamentally from human speech.
Monkeys were also enough trained to vocalize in response to auditory stimulus of a monkey's coo vocalization for more than three months (audio-initiated vocalization). Field potentials on the audio-initiated vocalization were recorded with the electrodes described above, and reaction times were measured from the onset of stimulus to the start of vocalization. A s-N,d-P potential was recorded at a latency of about 70 ms after the stimulus in the anterior bank of the inferior limb of the arcuate sulcus in the left hemisphere in which no significant potential was recorded on self-paced vocalization. In the motor and somatosensory cortices, s-N,d-P potentials were recorded at a latency of about 300 ms. Reaction times were obviously longer and more variable when compared with the audio-initiated hand movements^1 reported before.
1.Gemba & Sasaki, Exp.Brain Res. (1987) 65 : 649-657 Less

  • Research Products

    (38 results)

All Other

All Publications (38 results)

  • [Publications] Gemba,H.: "Changes in cortical field potentials during learning processes of go/no-go reaction time hand movement with tone discrimination in the monkey." Neurosci.Lett.159. 21-24 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sasaki,K: "No-go activity in the frontal association cortex of human subjects." Neurosci.Res.18. 249-252 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tsujimoto,T.: "Effect of cooling the dentate nucleus of the cerebellum on hand movement of the monkey." Brain Res.629. 1-9 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sasaki,K: "Action of the cerebello-thalamo-cortical projection upon visually initiated reaction-time hand movements in the monkey." Stereotact.Funct.Neurosurg.60. 104-120 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Gemba,H.: "Field potential chahges in the prefrontal cortex of the left hemisphere during learning process of reaction-time hand movement with complex tone in the monkey." Neurosci.Res.Suppl.18. S165 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Gemba,H.: "Functional differences between the prefrontal cortices of left and right cerebral hemispheres in the monkey." Jpn.J.Physiol.43,Suppl.2. S250 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sasaki,K: "Usefulness and limitation of MEG studies on the brain function." Jpn.J.Physiol.43 Suppl.2. S28 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sasaki,K: "Prefrontal activity on no-go decision." Advances in Biomagnetism. Abstract. 158-159 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nambu,A.: "Magnetic fields in the cerebral cortex associated with visually initiated finger movements in human subjects." Soc.Neurosci.Abstr.19. 1208 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nambu,A.: "Magnetic fields in the cerebral cortex associated with visually initiated finger movements in human subjects." Advances in Biomagnetism. Abstract. 146-147 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Gemba,H.: "Cortical field potentials preceding vocalization in monkeys." Neurosci.Res.Suppl.19. S190 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miki,N.: "Thalamocortical projections from the anterior thalamus onto layer 1 of the prefrontal cortex in monkeys." Jpn.J.Physiol.44 Suppl.1. S229 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sasaki,K.: "Magnetoencephalographical study on the motor speech centre." Jpn.J.Physiol.44 Suppl.1. S235 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Gamba,H.: "Cortical field potentials preceding vocalization in monkeys and influences of cerebellar hemispherectomy upon the potentials and vocalization." Jpn.J.Physiol.44 Suppl.1. S226 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sasaki,K.: "Motor speech centres in the frontal cortex." Neurosci.Res.in press (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玄番,央恵: "NO-GO potential (I)" 臨床脳波. 36. 746-753 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玄番,央恵: "NO-GO potential (II)" 臨床脳波. 36. 821-827 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sasaki,K.: "Brain Mechanisms of Perception and Memory.From Neuron to Behavior" T.Ono.et al., 24 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sasaki,K.: "Role of the Cerebellum and Basal Ganglia in Voluntary Movement." N.Mano,I.Hamada and M.R.DeLong., 10 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玄番 央恵: "発達と脳のメカニズム" 久保田 競, 20 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sasaki,K: "Motor and Cognitive Functions of the prefrontal cortex." Thierry A.-M.et al., 21 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 佐々木和夫: "研究報告書" 厚生省特定疾患運動失調症調査研究班, 4 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 逵本 徹: "研究報告書" 厚生省特定疾患運動失調症調査研究班, 4 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Gemba, H: "Changes in cortical field potentials during learning processes of go/no-go reaction time hand movement with tone discrimination in the monkey." Neurosci.Lett.159. 21-24 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sasaki, K: "No-go activity in the frontal association cortex of human subjects." Neurosci.Res.18. 249-252 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsujimoto, T.: "Effect of cooling the dentate nucleus of the cerebellum on hand movement of the monkey" Brain Res.629. 1-9 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sasaki, K: "Action of the cerebello-thalamo-cortical projection upon visually initiated reaction-time hand movements in the monkey." Stereotact.Funct.Neurosurg.60. 104-120 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Gemba, H: "Field potential changes in the prefrontal cortex of the left hemisphere during learning process of reaction-time hand movement with complex tone in the monkey" Neurosci.Res., Suppl.18. S165 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Gemba, H: "Functional differences between the prefrontal cortices of left and right cerebral hemispheres in the monkey." Jpn.J.Physiol.43.Suppl.2. S250 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sasaki, K: "Usefulness and limitation of MEG studies on the brain function." Jpn.J.Physiol.43, Suppl.2. S28 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sasaki, K: "Prefrontal activity on no-go decision." Advances in Biomagnetism, Abstract. 158-159 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nambu, A.: "Magnetic field in the cerebral cortex associated with visually initiated finger movements in human subjects." Soc.Neurosci.Abstr.19. 1208 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nambu, A.: "Magnetic fields in the cerebral cortex associated with visually initiated finger movements in human subjects." Advances in Biomagnetism, Abstract. 146-147 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Gemba, H: "Cortical field potentials preceding vocalization in monkeys." Neurosci.Res., Suppl.19. S190 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miki, N.: "Thalamocortical projections from the anterior thalamus onto layr 1 of the prefrontal cortex in monkeys." Jpn.J.Physiol.44.Suppl.1. S229 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sasaki, K: "Magnetoencephalographical study on the motor speech center." Jpn.J.Physiol.44.Suppl.1. S235 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Gemba, H: "Cortical field potentials preceding vocalization in monkeys and influences of cerebellar hemispherectomy upon the potentials and vocalization." Jpn.J.Physiol.44.Suppl.1. S226 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sasaki, K: "Motor speech centers in the frontal cortex." Neurosci.Res.(in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1996-04-15  

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