1994 Fiscal Year Final Research Report Summary
Effects of prostaglandin and noradrenalin on sleep-related neurons in the preoptic area.
| Project/Area Number |
05807006
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | OSAKA BIOSCIENCE INSTITUTE |
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Principal Investigator |
OSAKA Toshimasa Osaka Bioscinece Institute, Research Scientist, 第2研究部, 研究員 (30152101)
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| Co-Investigator(Kenkyū-buntansha) |
HAYAISHI Osamu Osaka Bioscinece Institute, Director, 所長 (40025507)
MATSUMURA Hitoshi Osaka Bioscience Institute, Vice Head, 第2研究部, 副部長 (50173886)
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| Project Period (FY) |
1993 – 1994
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| Keywords | Sleep / Neuron / Prostaglandin / Noradrenaline / Preoptic area |
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| Research Abstract |
Electrical stimulation of noradrenergic cells in the locus coeruleus and ventrolateral medulla inhibited sleep-active neurons and excited waking-active neurons in the preoptic area of the rat. Noradrenaline applied through a multibarrel micropipette also inhibited sleep-active neurons and excited waking-active neurons. Application of antagonists and agonists for adrenoceptors revealed that inhibition was mediated by alpha_2-and excitation by alpha_1-receptors.
During wakefulness, prostaglandin D_2 (PGD_2) excited sleep-active neurons and inhibited waking-active neurons. Continuous application of PGD_2 attenuated neuron activity during wakefulness. However, PGD_2 was less effective in eliciting a response during sleep. PGD_2 also attenuated noradrenaline-induced responses of sleep-related neurons.
These results suggest (1) noradrenaline promotes wakefulness by inhibiting sleep-active neurons through alpha_2-receptors and by exciting waking-active neurons through alpha_1-receptors, (2) PGD_2 promotes sleep by exciting sleep-active neurons and by inhibiting waking-active neurons, (3) most important action of PGD_2 is the attenuation of activity during wakefulness, and (4) PGD_2 attenuates the noradrenaline-mediated arousal influence.
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[Publications] Matsumura, H., Nakajima, T., Osaka, T., Satoh, S., Kawase, K., Kubo, E., Kantha, S.S., Kasahara, K.and Hayaishi, O.: "Prostaglandin D_2-sensitive, sleep-promoting zone defined in the ventral surface of the rostral basal forebrain." Proceedings of the National Academy of Sciences USA. 91. 11998-12002 (1994)
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