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1995 Fiscal Year Final Research Report Summary

HTLV-1 infection in japan, Hawaii, and California : the effect of immigration from endemic southwestern Japan

Research Project

Project/Area Number 06042008
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionSpecial Cancer Research
Research InstitutionTottori University

Principal Investigator

HINO Shigeo  Tottori University, Faculty of Medicine, Professor, 医学部, 教授 (70012763)

Co-Investigator(Kenkyū-buntansha) FROHLICH J.a  Blood Bank of Hawaii, Director, 所長
MURPHY Edward  University of California at San Francisco, Associate Professor, 医学部, 助教授
TSUJI Yoshiro  Nagasaki University, School of Medicine, Professor, 医学部, 教授 (30039812)
Project Period (FY) 1994 – 1995
KeywordsATL / HTLV-1 / Mother-to-child Infection / Milk-bornr Infection / Intrauerine Infection / PCR / Sexual Transmission / Sexual Behavior
Research Abstract

Several studies have documented declining HTLV-1 seroprevalence among immigrants to non-endemic areas within one or two generations. we hypothesized a decrease in sexual transmission due to assimilation into the low-prevalence host population. and performed family studies of 22 Japanese-American (JA) HTLV-1+ women (cases) to a group of 80 Japanese (JN) HTLV-1+ women in Nagasaki (controls). The JA women were older than the JN women (median age 50 vs. 33) : JA women were enrolled from blood donor population, and JN women from postnatal care clinic. Educational level of JA women was higher than that of JN women. Antibody titers were slightly higher in the JA women (median 1/64 vs. 1/16), but the difference was not significant after adjustment for age. By the time of this report, the viral load analysis by PCR was done, waiting for computer analysis. Questionnaire data revealed that 75 (90%) of JN nad 20 (90%) of JA women had been breast-fed by their mothers, and both groups had similar duration of breast-feeding. There was no difference in HTLV-1 seroprevalence among current sexual partners of the JA women (2/11,18%) compared to partners of JN women (4/20,20%), Both groups had a median of 2 lifetime male sexual partners.
Significantly (p<.05) more JN women than JA women reported that their current of previous sexual partner was from an endemic area (Kyushu, Shikoku or Okinawa) : 31/32 (97%) vs. 6/12 (50%). Condom usage was higher in the JN women, with 27 (33%) using a condom usually or always with their current partner, comared to only 3 (18%) of the 17 JA women with a current parther. We conclude that the immigration-related decline in HTLV-1 seroprevalence may be due to reduced sexual exposure of immigrant women to men from HTLV-1 endemic areas. Breast-feeding exposure was similar in endemic and immigrant women.

  • Research Products

    (32 results)

All Other

All Publications (32 results)

  • [Publications] Miyata H: "Dependency of antibodytiter on provirus load in human T-lymphotropic virus type 1 (HTLV-1) carriers : an interpretation for the minor populaiton of seronegative carriers." J Infect Dis. 171. 1455-1460 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hino S: "Maternal antibodies to the external envelope glycoprotein of HTLV-1 as a marker of mother-to-child transmission : differential risk in bottle-fed and breast-fed children." J Clin Invest. 95. 2920-2925 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kramer A: "Risk factors and cofactors for HAW-TSP in Jamaica." Am J Epidemiol. 142. 1212-1220 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Higashiyama Y: "Expression of human T-lymphotropic virus type 1 (HTLV-1) tax/rex gene in fresh bronchoalveolar lavage cells of HTLV-1-infected individuals." Clin Exp Immunol. 96. 193-201 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakamura Y: "Altered expression of a novel celluar geneas a consequence of integration of human Tcell lymphotropic virus type 1." J Gen Virol. 75. 2625-2633 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hino S: "Intervention of maternal transmission of HTLV-1 in Nagasaki,Japan." Leukemia. 8 (Supplel). S68-S70 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Katamine S: "HTLV-1 proiral DNA in umbilical cord blood of babies born to carrier mothers." Lancet. 343. 1326-1327 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sun M: "Seroprevalence of human T-lymphotropic virus (HTLV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) in Asian American potential bone marrow donors." Transfusion. 34. 344-348 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Vyas GN: "Transfusion-related transmissible diseases : detection by polymerase chain reaction-amplified genes the microbial agents." Transfusion Med Rev. 8. 253-266 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Agranoff D: "Seroporevalence of HTLV-I and HTLV-II among emergency room and clinic patients in San Francisco." West J Med. (in press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Zuck TF: "The retrovirus epidemiology donor study (REDS) : rationale and methods." Transfusion. (submitted).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Murphy EL: "Health effects of human T-lymphotropic virus type I (HTLV-I) in a Jamaican cohort." Int J Epidemiol. (submitted).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Murphy EL: "High prevalence of HTLV-associated myelopathy in a cohort of HTLV-I and HTLV-II infected blood donors." Neurology. (submitted).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kaplan J: "Male-to-female transmission of human t-lymphotropic virus types I and II : association with virus load." J Acquired Immun Defic Syndrome. (submitted).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Murphy EL: "Demographic determinants of hepatitis C virus (HCV) seroprevalence in blood donors in the United States." JAMA. (submitted).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Modahl LE: "Injection durg users serporisitive for human T-lymphotropic virus type II (HTLV-II) are at increased risk for pneumonia,abscess and lymphadenopathy." Clin Infect Dis. (submitted).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miyata H: "Dependency of antibodytiter on provirus load in human T-lymphotropic virus type 1 (HTLV-1) carriers : an interpretation for the minor populaiton of seronegative carriers." J Infect Dis. 171. 1455-1460 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hino S: "Maternal antibodies to the external envelope glycoprotein of HTLV-1 as a marker of mother-to-child transmission : differential risk in bottle-fed and breastfed children." J Clin Invest. 95. 2920-2925 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kramer A: "Risk factors and cofactors for HAM-TSP in Jamaica" Am J epidemiol. 142. 1212-1220 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Higashiyama Y: "Expression of human T-lymphotropic virus type 1 (HTLV-1) tax/rex gene in fresh bronchoal veolar lavage cells of HTLV-1-infected individuals." Clin Exp Immunol. 96. 193-201 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakamura Y: "Altered expression of a novel celluar geneas a consequence of integration of human Tcell lymphotropic virus type 1." J Gen Virol. 75. 2625-2633 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hino S: "Intervention of maternal transmission of HTLV-1 in Nagasaki, Japan." Leukemia. 8(Supple 1). S68-S70 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Katamine S: "HTLV-1 proviral DAN in umbilical cord blood of babies born to carrier mothers." Lancet. 343. 1326-1327 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sun M: "Seroprevalence of human T-lymphotropic virus (HTLV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) in Asian American potential bone marrow donors" Transfusion. 34. 344-348 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Vyas GN: "Transfusion-related transmissible diseases : detection by polymerase chain reaction-amplified genes of the microbial agents." Transfusion Med Rev. 8. 253-266 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Agranoff D: "Seroprevalence fo HTLV-1 and HTLV-11 among emergency room and clinic patients in San Francisco." West J Med. in press.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Zuck TF: "The retroirus epidemiology donor study (REDS) : rationale and methods." Transfusion. submitted.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murphy EL: "Health effects of human T-lymphotropic virus type I (HTLV-1) in a Jamaican cohort." Int J Epidemiol. submitted.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murphy EL: "High prevalence of HTLV-associated myelopathy in a cohort of HTLV-I and HTLV-II infected blood donores." Neurology. submitted.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kaplan J: "Male-to-female transmission of human T-lymnphotropic virus types I and II : association with viral load." J Acquiered Immun Defic Syndrome. submitted.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murphy EL: "Demographic determinants of hepatitis C virus (HCV) seroprevalence among blood donors in the United states." JAMA. in press.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Modahl LE: "Injection drug users seropositive for human T-lymphotropic virus type II (HTLV-II) are at incereased risk for pneumonia, abscess and lymphadenopathy." Clin Infect Dis. submitted.

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1997-03-04  

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