1995 Fiscal Year Final Research Report Summary
Investigation on the association between chronic calcifying pancreatitis and pancreatic duct carcinoma
| Project/Area Number |
06042015
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Special Cancer Research |
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| Research Institution | Department of Oncological Pathology, Nara Medical University |
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Principal Investigator |
KONISHI Yoichi Nara Medical University, Professor, 医学部, 教授 (00075061)
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| Co-Investigator(Kenkyū-buntansha) |
CHELLAM V.g Trivandrum Medical School, 医学部, 教授
HARIHARAN M. Trivandrum Medical School, 医学部, 教授
MORI Mitsuru Saga Medical School, 医学部, 助教授 (50175634)
ISHIKAWA Osamu Osaka Medical Center for Cancer, 室長
TSUTSUMI Masahiro Nara Medical University, 医学部, 講師 (00207416)
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| Project Period (FY) |
1994 – 1995
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| Keywords | Kerala, India / CCPT / PDA / PDA with CCPT / Pancreatic stone / Cassava / K-ras突然変異 / p53突然変異 |
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| Research Abstract |
Chronic calcifying pancreatitis is mostly seen in Tropics and more commonly in Southern India of Kerala state. We investigated clinicopathologically the association of pancreatic duct adenocarcinoma (PDA) and chronic calcifying pancreatitis of tropic (CCPT) from 1994 to 1995. The populations were divided into 4 groups (Gs) and collected cases were 146 normal cases (G1), 44CCPT (G2), 79PDA (G3) and 23PDA with CCPT (G4). Age and sex matched people were used as control (G1). Sex ratio, male to female, was 26 : 1 in G2,3 : 1 in G3, and 0.6 : 0.39, in G4. Mean age range was 36.7 in G2,56.2 in G3, and 45.4 in G4. Pain, jaundice, and weight loss were main symptomes in Gs3 and 4 and DM complications were 15/79 in G3 and 14/23 cases in G4. Stones were detected 95.4% in G2 and 100% in G4 but 0% in G3 and further stones detected in G4 were all diffusely located in the main duct and there were no correlation between the sites of stones and cancer locations and cancers were located in the head of pancreas in the majority of cases in Gs3 and 4. The main treatment was By-pass operation and the resectability was 7.6% in G3 and 4.3% in G4 and the survival was approximately one year in Gs3 and 4. Interestingly, liver metastasis was seen only 1/23 cases in G4 but 33/79 in G3. Histologically, all cancers were well to poorly differentiated adenocarcinomas in G3 but well differentiated carcinomas were not seen in G4. Epidermiologically, odds ratio showed that high intake of casava is 7 times high risk factor for PDA with CCPT.These results indicat that there was positive association between CCPT and PDA and suggest that high intake of lowprotein high-carbohydrate diet like cassava contributes the development of CCPT with PDA in Kerala, India.
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