1995 Fiscal Year Final Research Report Summary
Comperative study in the viability of the liver graft harvested from cadaver and living donor, evaluated by assessment of tissue oxygenation in sinusoid and oxidation of hepatocyte
| Project/Area Number |
06044127
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Joint Research |
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
YAMAOKA Yoshio Professor, Kyoto University, 医学研究科, 教授 (90089102)
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| Co-Investigator(Kenkyū-buntansha) |
ウオニカイト クルト ハノーファー医科大学, 教授
ピッケルマイヤー ルドル ハノーファー医科大学, 教授
IKAI Iwao Assistant, Kyoto University, 医学研究科, 助手 (60263084)
OZAKI Nobuhiro Assistant, Kyoto University, 医学研究科, 助手 (50211818)
UEMOTO Shinji Assistant, Kyoto University, 医学研究科, 助手 (40252449)
INOMATA Yukihiro Assistant Professor, Kyoto University, 医学研究科, 講師 (50193628)
TANAKA Akira Assistant Professor, Kyoto University, 医学研究科, 講師 (00240820)
INAMOTO Takashi Professor, Kyoto University, College of Medical Technology and Nursing, 医療技術短期大学部, 教授 (10135577)
TANAKA Koichi Associate Professor, Kyoto University, 医学研究科, 助教授 (20115877)
WONIGEIT Kurt Professor
PICHLMAYR Rudorf Professor
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| Project Period (FY) |
1994 – 1995
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| Keywords | Liver TRASPLANTATION / REGECTION / Near infra-red spectroscopy / micro circulation / hepaticsinusoid / oxygen satulation / primary-nonfunction |
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| Research Abstract |
As hemoglobin can be used as an optical parameter of microcirculation, oxygen saturation and content of hemoglobin of red cells in the liver sinusoids can be evaluated with tissue near-infrared spectroscopy. Using this novel method, we have studied relationship between the circulation status and post-transplantation pathophisiology. Grafts that presented aspiration cytology scores of 2 or more at 1 week after operation (groupI, n=14) were associated with a higher heterogeneity than grafts with no or very mild intragraft immune activation (group II,n=33). Group I was also accompanied by higher postoperative peak GOT level and higher donor age. Heterogenous reperfusion, higher peak GOT level and higher donor age were also associated with clinical rejection at 1week, but not with later-onset rejection.
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