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1996 Fiscal Year Final Research Report Summary

Clinicopathological study on the presence of dendritic cells and the expression of oncogene products in malignant tumors

Research Project

Project/Area Number 06045037
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionUniversity-to-University Cooperative Research
Research InstitutionKochi Medical School

Principal Investigator

OHTSUKI Yuji  Kochi Medical School, Professor, 医学部, 教授 (30136387)

Co-Investigator(Kenkyū-buntansha) ちゃん 永国  佳木斯医学院, 医学系, 教授
張 憲有  佳木斯医学院, 医学系, 教授
JIANG Jiwen  Jiamusi Medical College, Associate Professor, 医学系, 副教授
白 秀英  佳木斯医学院, 医学系, 講師
陶 富山  佳木斯医学院, 医学系, 教授
IDO Eiji  Kochi Medical School, Research Associate, 医学部, 助手 (20223208)
FURIHATA Mutsuo  Kochi Medical School, Research Associate, 医学部, 助手 (10209158)
IWATA Jun  Kochi Medical School, Research Associate, 医学部, 助手 (30232680)
SONOBE Hiroshi  Kochi Medical School, Associate Professor, 医学部, 助教授 (20145121)
ZHENG Yongguo  Jiamusi Medical College, Professor
ZHANG Xianyou  Jiamusi Medical College, Professor
BAI Xiuying  Jiamusi Medical College, Lecture
TAO Fusha  Jiamusi Medical College, Professor
Project Period (FY) 1994 – 1996
KeywordsS-100 protein / P53 protein / Immunohistochemistry / Esophageal cancer / Urinary bladder cancer / Pelvic & ureteral cancer / Skin cancer / Sarcoma
Research Abstract

Clinicopathological study on the presence of S-100 protein positive dendritic cells and the expressions of oncogene products, such as p53, Rb, MDM-2, bcl-2, has been made immunohistochemically using both Japanese and Chinese patients with cancer. The kinds of carcinomas investigated were skin, liver, urinary bladder, esophagus, renal pelvis, ureter and larynx, and some sarcomas. As for S-100DC,these cells in increased numbers are a valuable marker for better prognosis in hepatocellular carcinoma, transitional cell carcinoma of urinary bladder and squamous cell carcinoma of esophagus. Similar results were obtained in Chinese patients with esophageal and urinary bladder carcinoma. p53 protein positivity of esophageal, renal pelvic and ureteral carcinoma showed the intimate relationship with poor prognosis statistically. Human papilloma virus (HPV) type 16 and 18 infection as well as overexpressed MDM-2, cyclin A and D,and Rb was also suggested the patient's poor prognosis. In addition, p53 or bcl-2 expression detected in the dysplastic lesions of esophagus, ureter, and renal pelvis suggested that these overexpressions might be an early event in carcinogenesis.
Thus, the presence of S-100DC in increased numbers is the favorable marker, but HPV infection as well as overexpressed oncogene products or cyclins in cancer cells is the worse marker for the prognosis of cancer patients. As for S-100DC in sarcomas, especially osteosarcoma, there detected only few or no such kind of cells in the tumor tissues, as far as examined. These results may suggest the poor prognosis of these sarcoma patients, but further investigations are needed to clarify the exact meaning of these results.

  • Research Products

    (40 results)

All Other

All Publications (40 results)

  • [Publications] H.Ono,et al.: "Relationship between H-ras product and p53 protein or high-risk human papillomaviruses in esophageal cancer from Kochi,Japan" Am.J.Gastroenterol.89. 646-647 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Ono,et al.: "Interrelationship between the expression of H-ras p21,c-myc and p53 proteins,and the infection of high-risk human papillomaviruses in Japanese patients with esophageal squamous cell carconima" Oncol.Report. 1. 831-836 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E.Ido,et al.: "S-100 protein positive dendritic cells detected in hepatocellular carcinoma in relation to tumor progression and prognosis" Int.J.Oncol.5. 231-236 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Hayashi,et al.: "Search for accumulation of p53 protein and detection of human papillomavirus genomes in sebaceous gland carcinoma of the eyelid" Virchows Arch.424. 503-509 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Furihata,et al.: "The aberrant p53 protein (Review)" Int.J.Oncol.6. 1209-1226 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Furihata,et al.: "p53 and human papillomavirus DNA in renal pelvic and ureteral carcinoma including dysplastic leisons" Int.J.Cancer. 64. 298-303 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Furihata,et al.: "Detection of p53 and bcl-2 protein in carcinoma of the renal pelvis and ureter including dysplasia" J.Pathol.178. 133-139 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] I.Yamasaki,et al.: "Overexpression of MDM2 and p53 protein is infrequently but significantly associated with progression of human prostatic adenocarinoma" Oncology Report. 3. 925-929 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] J.Iwata,et al.: "high frequency of apoptosis in infantile capillary haemangioma" Journal of Pathology. 179. 403-408 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 石川忠則他: "食道癌におけるヒトパピローマウイルスと癌関連遺伝子" 消化器外科. 19. 1587-1594 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Furihata,et al.: "Determination of the prognostic significance of unscheduled cyclin A overexpression in patients with esophageal squamous cell carcinoma" Clinical Cancer Research. 2. 1781-1785 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Ohta,et al.: "Overexpressed cyclin D1 protein related to p53 and retinoblastoma proteins in transitional cell carcinoma of the urinary tract" Oncology Reports. 4. 91-101 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Ohtsuki,et al.: "Immunohistochemical analysis of S-100 protein positive dendritic cells in human cutaneous squamous cell carcinomas,Bowen's diseases and basal cell carcinomas In : "Lymphoreticular Cells and Diseases"" Korea Medical Publishing Company, 409 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Furihata,et al.: "HLA-DR antigen-and/or S-100 protein-positive dendritic cells as prognostic indicators in esophageal squamous cell carcinoma In : "Lymphoreticular Cells and Diseases"" Korea Medical Publishing Company, 409 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E.Ido,et al.: "S-100 protein positive dendritic cells detected in hepatocellular carcinoma in relation to tumor progression and prognosis In : "Proc.of the fourth Japanese-Korean Lymphoreticular Workshop"" Shinko-do, 457 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Inoue,et al.: "Distribution of S-100 protein-positive dendritic cells and expression of HLA-DR antigen in transitional cell carcinoma of the urinary bladder in relation to tumor progression and prognosis In : "Proc.of the fourth Japanese-Korean Lymphoreticular Workshop"" Shinko-do, 457 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Ohtsuki,et al.: "Immunoelectron microscopic study of non-neoplastic and leukemic S-100 protein positive T lymphocyte in human peripheral blood In : "Proc.of the fourth Japanese-Korean Lymphoreticular Workshop"" Shinko-do, 457 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Ohtsuki and M.Furihata: "Transitional cell carcinoma and dendritic cells" Bunko-do (in press), (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Ogoshi,et al.: "Human papillomavirus infection and alterations of p53 in esophageal cancer In : "Recent Advances in Gastroenterological Carcinogenesis I"" Monduzzi Editore S.p.A., 1232 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Ishikawa,et al.: "Demonstration of cyclin (D1,E) and RB protein expression in human esophageal squamous carcinoma In : "Recent Advances in Gastroenterological Carcinogenesis I"" Monduzzi Editore S.p.A., 1232 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Ono, et al.: "Relationship between H-ras product and p53 protein or high-risk human papillomaviruses in esophageal cancer from kochi, Japan" Am.J.Gastroenterol.89. 646-647 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Ono, et al.: "Interrelationship between the expression of H-ras p21, c-myc and p53 proteins, and the infection of high-risk humanpapillomaviruses in Japanese patients with esophageal squamous cell carcinoma" Oncol.Report. 1. 831-836 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.Ido, et al.: "S-100 protein positive dendritic cells detected in hepatocellular carcinoma in relation to tumor progression and prognosis" Int.J.Oncol.5. 231-236 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Hayashi, et al.: "Search for accumulation of p53 protein and detection of human papillomavirus genomes in sebaceous gland carcinoma of the eyelid" Virchows Arch.424. 503-509 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Furihata, et al.: "The aberrant p53 protein (Review)" Int.J.Oncol.6. 1209-1226 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Furihata, et al.: "p53 and human papillomavirus DNA in renal pelvic and ureteral carcinoma including dysplastic lesions" Int.J.Cancer. 64. 298-303 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Furihata, et al.: "Detection of p53 and bcl-2 protein in carcinoma of the renal pelvis and ureter including dysplasia" J.pathol.178. 133-139 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] I.Yamasaki, et al.: "Overexpression of MDM2 and p53 protein is infrequently but significantly associated with progression of human proctatic adenocarcinoma" Oncology Report. 3. 925-929 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] J.Iwata, et al.: "High frequency of apoptosis in infantile capillary haemangioma" Journal of Pathology. 179. 403-408 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Ishikawa, et al.: "Human papillomavirus and oncogenesis-related genes in esophageal cancer" Shokaki-Geka. 19. 1587-1594 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Furihata, et al.: "Determination of the prognostic significance of unsheduled cyclin A overexpression in patients with esophageal squamous cell carcinoma" Clinical Cancer Research. 2. 1781-1785 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Ohta, et al.: "Overexpressed cyclin D1 protein related to p53 and retinoblastoma in transitional cell carcinoma of the tract" Oncology Reports. 4. 91-101 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Ohtsuki, et al.: Korea Medical Publishing Company. Immunohistochemical analysis of S-100 protein positive dendritic cells in human cutaneous squamous cell carcinomas, Bowen's diseases and basal cell carcinoma In : Lymphoreticular Cells and Diseases, 227-235 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Furihata, et al.: Korea Medical Publishing Company. HLA-DR antigen- and/or S-100 protein-positive dendritic cells as prognostic in esophageal squamous cell carcinoma In : Lymphoreticular Cells and Diseases, 236-244 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E.Ido, et al.: Shinko-do. S-100 protein positive dendritic cells detected in hepatocellular carcinoma in relation to tumor progression and prognosis In : Proc.of the fourth Japanese-Korean Lymphoreticular Workshop, 155-166 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Inoue, et al.: Shinko-do. Distribution of S-100 protein-positive dendritic cells and expression of HLA-DR antigen in transitional cell carcinoma of the urinary bladder in relation to tumor progression and prognosis In : Proc.of the fourth Japanese-Korean Lymphoreticular Workshop, 179-187 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Ohtsuki, et al.: Shinko-do. Immunoelectron microscopic study of non-neoplastic and leukemic S-100 protein positive T lymphocyte in human peripheral blood In : Proc.of the fourth Japanese-Korean Lymphoreticular Workshop, 301-310 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Ohtsuki and M.Furihata: Bunko-do. Transitional cell carcinoma and dendritic cells (in press), (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Ogoshi, et al.: Monduzzi Editore S.p.A.Human papillojmavirus intection and alterations of p53 in esophageal cancer In : Recent Advances in Gastroenterological Carcinogenesis I, 45-49 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Ishikawa, et al.: Monduzzi Editore S.p.A.Demonstration of cyclin (D1, E) and RB protein expression in human esophageal squamous carcinoma In : Recent Advances in Gastroenterological Carcinogenesis I, 377-381 (1996)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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