分子進化学の新展開

1994 Fiscal Year Annual Research Report

• Project/Area Number: 06273103
• Research Institution: The Institute of Statistical Mathematics
• Principal Investigator: 長谷川 政美 統計数理研究所, 予測制御研究系, 教授 (60011657)
• Co-Investigator(Kenkyū-buntansha): 岡田 典弘 東京工業大学, 生命理工学部, 教授 (60132982) ; 宝来 聡 国立遺伝学研究所, 総合遺伝研究系, 助教授 (40126157) ; 植田 信太郎 東京大学, 大学院・理学系研究科, 助教授 (20143357) ; 五條堀 孝 国立遺伝学研究所, 遺伝情報センター, 教授 (50162136) ; 宮田 隆 京都大学, 理学部, 教授 (20022692)
• Keywords: 機能的制約 / カンブリア紀 / 多細胞動物 / 弥生人 / ミトコンドリアDNA / アフリカ起源説 / 肝炎ウイルス / 分子系統樹

Research Abstract

1.カンブリア紀における多細胞動物の爆発的進化は、新しい生態的ニッチェの獲得によるマクロなレベルでの機能的制約の緩和によるものと考えられるが、それに伴って起こった遺伝子レベルでの制約が緩和の爆発的進化の遺伝的な基礎になっていることを示した。(宮田)。
2.弥生人の骨からミトコンドリアDNAを採取解析し、弥生人の遺伝的構成が多様であることを示した(植田)。
3.アフリカ人、ヨーロッパ人、日本人、および3種のアフリカ類人猿とオランウータンのミトコンドリア全ゲノム配列を解析し、現生人類のアフリカ起源説を強く指示する結果を得た。(宝来)。
4.C型肝炎ウイルスの分子進化的研究が、このウイルスの臨床的診断にも有用であることを示した(五條堀)。
5.反復配列SINEを用いて動物の系統関係を知るための方法を確立した(岡田)。
6.分子系統樹推定のためのプログラム・パッケージを開発整備し、さらにこれを用いたデータ解析により、ミトコンドリアをもたない原生生物の系統的位置、哺乳類の系統進化などに関して新たな知見を得た(長谷川)。

Research Products

• [Publications] Hashimoto,T.: "Protein phylogong gives a robust estimation" Molecular Bilogy and Evolution. 11. 65-71 (1994)
• [Publications] Hasegawa,M.: "Accuracies of the simple methods for estimating bootstrap prob." Molecular Biology and Evolution. 11. 142-145 (1994)
• [Publications] Cao,Y.: "Phylogenetic place of guinea pigs" Molecular Bilogy and Evolution. 11. 593-604 (1994)
• [Publications] Cao,Y.: "Phylogenetic relationships among eutherian orders" Journal of Molecular Evolution. 39. 519-527 (1994)
• [Publications] Shirakura,T.: "Phylogenetic place of a mitochondria-lacking protozoan" Japanese Journal of Genetics. 69. 119-135 (1994)
• [Publications] Cao,Y.: "Eutherian phylogeny" Japanese Journal of Genetics. 69. 455-472 (1994)
• [Publications] Adachi,J.: "Phylogeny of Whales" Molecular Bilogy and Evolution. 12. 177-179 (1995)
• [Publications] Nikoh,N.: "Phylogenetic relationships of the kingdoms" Molecular Bilogy and Evolution. 11. 762-768 (1994)
• [Publications] Miyata,T.: "A possible link between molecular evolution and tissue evolution" Japanese Journal of Genetics. 69. 473-480 (1994)
• [Publications] Seki,N.: "Horseshoc crab(1,3)-B-D-Glucan-sensitive coagulation factor" Journal of Biological Chemistry. 269. 1370-1374 (1994)
• [Publications] Takeshima,H.: "Isolation and charactrization of a gene for a ryanodine receptor" FEBS Letters. 337. 81-87 (1994)
• [Publications] Haino,M.: "Comparison and evolution of immunoglobulin VH sogments" Journal of Biological Chemistry. 269. 2619-2626 (1994)
• [Publications] Ohashi,K.: "Cloning of a novel receptar tyrosine kinase,sky" Oncogene. 9. 699-705 (1994)
• [Publications] Fukada,K.: "cDNA cloning and rogional distribution" FEBS Letters. 343. 42-46 (1994)
• [Publications] Oyamada,H.: "The Primary atructure and distribution of ryanodine-binding" Journal of Biological Chemistry. 269. 17206-17214 (1994)
• [Publications] Kuma,K.: "Mammalian phylogeny inferred from multiple protein data" Japanese Journal of Genetics. 69. 555-566 (1994)
• [Publications] Kuma,K.: "Functional constraints against variations on molecules" Molecular Biology and Evolution. 12. 123-130 (1995)
• [Publications] Mizokami,M.: "Reduction of synonymous substitutions" Journal of Molecular Evolution. 38. 50-56 (1994)
• [Publications] Miura,T.: "Phylogenetic subtypes of human T-lymphotropic virus type I" Proceedings of National Academy of Science USA. 91. 1124-1127 (1994)
• [Publications] Gojobori,T.: "Molecular evolution of serine protease" Philosophical Transactions:Biologial Sciences. 344. 411-415 (1994)
• [Publications] Ishibashi,K.: "Molecular cloning and expression of a member of the aquaporin family" Proceedings of National Academy of Science USA. 91. 6269-6273 (1994)
• [Publications] Ina,Y.: "Statistical analysis of nucleotide sequences of the hemagglutinin" Proceedings of National Academy of Science USA. 91. 8388-8392 (1994)
• [Publications] Gojobori,T.: "Evolution of pathogenic viruses" Japanese Journal of Genetics. 69. 481-488 (1994)
• [Publications] Suzuki,K.: "Confirmation of hepatitis C virus transmission" Journal of Infectious Diseases. 170. 1575-1578 (1994)
• [Publications] Mizokami,M.: "Molecular evolutionary virology" Gastroenterology. 107. 1181-1182 (1994)
• [Publications] Saitou,N.: "Evolutionary rate of insertions and deletions" Molecular Biology and Evolution. 11. 504-512 (1994)
• [Publications] Tanabe,H.: "Regional asignment of the human immunoglobulin" Cytogenetics and Cell Genetics. 66. 93-95 (1994)
• [Publications] Atsuchi,Y.: "Cloning of a brain-type aldolase cDNA" Biochimica Biophysica Acta. 1218. 153-157 (1994)
• [Publications] Umetsu,K.: "Polymorphisms of complement component I" Human Biology. 66. 339-348 (1994)
• [Publications] Kadowaki,T.: "A subtype of diabetes mellitus" New England journal of Medicine. 330. 963-968 (1994)
• [Publications] Kawakami,Y.: "Mitochondrial myopathy" Annals of Neurology. 35. 370-373 (1994)
• [Publications] Marie,S.: "A Caucasian family with 3271mutation in mitochondrial DNA" Biochemical Medicene Metabol Biology. 52. 136-139 (1994)
• [Publications] Hattori,Y.: "Point mutations in mitochondrial tRNA genes" Journal of Neurological Science. 125. 50-55 (1994)
• [Publications] Goto,Y.: "A new point mutation at nucleotide pair 3291" Biochemistry Biophysics Research Communication. 202. 1624-1630 (1994)
• [Publications] Murakami,T.: "Enzymatic and genetic adoptation of soleus muscle mitochondr" American Journal of Physiology. 267. 388-395 (1994)
• [Publications] Horai,S.: "Recent African origin of modern humans" Proceedings of National Academy of Science USA. 92. 532-536 (1995)
• [Publications] Sakagami,M.: "A novel tRNA species as an origin of short repetitive elements" Journal of Molecular Biology. 239. 731-735 (1994)
• [Publications] Kido,Y.: "Amplification of distinct subfamilies of short interspersed elements" Journal of Molecular Biology. 241. 633-644 (1994)
• [Publications] Takasaki,N.: "Species-specific amplification of tRNA-derived SINEs" Proceedings of National Academy of Science USA. 91. 10153-10157 (1994)
• [Publications] Yokobori,S.: "Relationships among coelacanths,lungtishes,and tetrapods" Journal of Molecular Evolution. 38. 602-609 (1994)
• [Publications] Ohshima.K.: "Generality of the tRNA origin of short interspersed repetitive elements" Journal of Molecular Biology. 243. 25-37 (1994)
• [Publications] Nakanishi,S.: "A UGU sequence in the anticodon loop" Journal of Biological Chemistry. 269. 32221-32225 (1994)
• [Publications] Inagaki,H.: "Expression of the tyrosine-encoding gene" Gene. 150. 319-324 (1994)
• [Publications] Koga,A.: "Body color mutants and a transposable element" The Fish Biology Journal MEDAKA. 6. 7-15 (1994)
• [Publications] Kobayashi,M.: "Mechanisms of histolysis in indirect flight muscles" Journal of Insect Physiology. 40. 33-38 (1994)
• [Publications] Kobayashi,M.: "Involvement of juvenile hormone" Journal of Insect Physiology. 40. 107-111 (1994)
• [Publications] Fukatsu,T.: "Differentiation of aphid clones" Molecular Ecology. 3. 187-192 (1994)
• [Publications] Fukatsu,T.: "Phylogeny of Cerataphidini aphids" Zoological Science. 11. 613-623 (1994)
• [Publications] Fujiwara,H.: "Mosaic formation by developmental loss of chromosomal" Roux's Archives of Developmental Biology. 203. 389-396 (1994)
• [Publications] Hongoh,Y.: "Changes of mycetocyte symliosis" Zoological Science. 11. 731-735 (1994)
• [Publications] Morioka,M.: "An endosymbiont chaperonin" Journal of Biochemistry. 116. 1075-1081 (1994)
• [Publications] 宮田隆: "分子進化学への招待" 講談社, 280 (1994)