1996 Fiscal Year Annual Research Report

分子進化学の新展開

Research Project

Project/Area Number	06273103
Research Institution	The Institute of Statistical Mathematics
Principal Investigator	長谷川政美統計数理研究所, 予測制御研究系, 教授 (60011657)
Co-Investigator(Kenkyū-buntansha)	堀寛名古屋大学, 大学院・理学研究科, 教授 (60116663) 岡田典弘東京工業大学, 生命理工学部, 教授 (60132982) 宝来聰国立遺伝学研究所, 総合遺伝研究系, 助教授 (40126157) 五條堀孝国立遺伝学研究所, 生命情報研究センター, 教授 (50162136) 宮田隆京都大学, 大学院・理学研究科, 教授 (20022692)
Keywords	分子進化 / 真核生物 / ミトコンドリア / 遺伝子の多様化 / 遺伝子重複 / HIV / アフリカ単一起源説 / SINE
Research Abstract	ミトコンドリアを持たない真核生物について、蛋白質をコードしているいくつかの遺伝子の系統学的な解析を行い、真核生物の初期進化に関して新たな知見を得た(長谷川)。進化の過程で遺伝子の多様化がどのように進んだかという問題を明らかにするために、多数の遺伝子族の分子進化学的解析を行った。その結果、遺伝子重複による遺伝子の多様化は、真核生物の進化の過程で徐々に起きたのではなく、断続的かつ急速に起きたことが明らかになった(宮田)。 HIVの遺伝子を分子進化的に解析し、その進化速度が異常に高いことを明らかにし、このウイルスの感染者体内における進化のメカニズムに関してもいくつかの知見を得た(五條堀)。 3人の現代人と4種の類人猿で、ミトコンドリアDNAの全塩基配列を調べた結果、現代人の共通祖先の年代は約14万年前と推定され、「アフリカ単一起源説」が強く支持された(宝来)。独自に開発したSINEによる系統樹推定法を用いて、クジラの起源の解明とタンガニイカ湖のカワスズメ科魚類の系統関係の決定を行った。クジラの起源に関しては、クジラ目と反芻亜目とカバが単系統をなすことを明らかにした(岡田)。その他、動物体色の発現機構の進化(堀)、細胞内共生細菌の進化(石川)、脳で特異的に発現している転写因子class III POUの分子進化(植田)、無脊椎動物の生体防御系の進化(石和)、などについても成果を挙げた。

Research Products

(60 results)

All Other

All Publications (60 results)

[Publications] Cao,Y.,Okada,N.,Hasegawa,M.: "Phylogenetic position of guinea-pigs revisited" Mol.Biol.Evol.(印刷中). (1997)
[Publications] Hasegawa,M.,Adachi,J.,et al.: "Novel phylogeny of whales supported by total molecular evidence." J,Mol,Evol.(印刷中). (1997)
[Publications] Aoshima,M.,Hasegawa,M.,et al.: "Cloning and seguencing of a gene encoding 16S ribosomal RNA from a novel hyperthemophilic archaebacterium NC12." Gene,. (印刷中). (1996)
[Publications] Hasegawa,M.,Fitch,W.M: "Dating the cenancestor of organisms" Science. 274. 1750-1750 (1996)
[Publications] Milinkovitch,M,C.,Hasegawa,M.,et al: "Effects of character weighting and species sampling on phylogeny reconstruction : a case" Genetics. 144. 1817-1833 (1996)
[Publications] Kamaishi,T.,Hasegawa,M.,etal.: "Complete nucleotide sequences of the gene encoding translation elongation factors 1alpha and 2 from a microsporidian parasite,Glugea plecoglossi : implications for the deopest branching of eukaryotes." J,Biochem. 120. 1095-1103 (1996)
[Publications] Hashimoto,T.,Hasegawa,M: "Origin and early evolution of eukaryotes inferred from the amino acidsequences of translation elongation factors 1alpha / Tu and 2/G." Adv,Biophy. 32. 73-120 (1996)
[Publications] Adachi,J.,Hasegawa,M: "MOLPHY Version 2.3 : Programs for Molecular Phylogenetics Based on Maximun Likelihood." Computer Science Monographs.28. 1-150 (1996)
[Publications] Kamaishi,T.,Hasegawa,M.,etal.: "Protein phylogeny of EF-1alpha suggests microsporidians are extremelyancient eukaryotes." J,Mol,Evol.,. 42. 257-263 (1996)
[Publications] Hasegawa,M.,Adachi,J: "Phylogenetic postion of cetaceans relative to artiodactyls : Reanalysis of mitochondrial and nuclear sequences." Mol.Biol.Evol.13. 710-717 (1996)
[Publications] Adachi,J.,Hasegawa,M: "Model of amino acid substitution in proteins encoded by mitochondrial DNA." J,Mol.Evol.42. 459-468 (1996)
[Publications] Nakamura,Y.,Hasegawa,M.,et al.: "Phylogenetic place of kinetoplastid protozoa inferred from protein phylogenies of elongation factors 1alpha and 2." J,Biochem.119. 70-79 (1996)
[Publications] Horai,S.,etal.: "DNA polymorphism in East Asian populations, with special reference tothe peopling of Japan." Am.J.Hum.Genet.59. 579-590 (1996)
[Publications] Hayasaka,K.,Fujii,K. and Horai,S: "Molecular phylogeny of macaques : implications of nucleotide sequences from an 896 base pair region of mitochondrial DNA." Mol.Biol.Evol.13. 1044-1053 (1996)
[Publications] Goto,Y.,Horai,S.,etal.: "Detection of DNA fragments encompassing the deletion junction of mitochondrial genome." Biochem.Biophy.Res.Commun.222. 215-219 (1996)
[Publications] Nishino,I.,Horai,S.,etal.: "A novel mutation in the mitochondrial tRNAThr gene associated with a mitochondrial encephalomyopathy." Biochem.Biophy.Res.Commun.225. 180-185 (1996)
[Publications] Nishino,I.,Horai,S.,etal.: "The 3260 mutation in mitochondrial DNA can cause mitochondrial myopathy,encephalopaty,lactic acidosis,and stroke-like episodes(MELAS)." Muscle & Nerve. 19. 1603-1604 (1996)
[Publications] Muraki,K.,Horai,S.,etal.: "Severe lactic acidosis and neonatal death in Pearson syndrome." J.Inher.Metab.Dis. (印刷中). (1997)
[Publications] Ozawa,M.,Horai,S.,etal.: "Mutations in mitochondrial tRNA Lys are responsible for myoclonus epilepsy asscciated with ragged-red fibers(MERRF)and cytochrume c oxidase defiency : an additional novel G-to-A mutation at nucleoride palr 8363 in tRNALys in two families." Muscle & Nerve. (印刷中). (1997)
[Publications] Blagitko,N.,Horai,S.,etal.: "Pelymorphism of the HLA-DRB1 locus in Colombian,Ecuadorian,and Chilean Amerinds." Human Immunology.(印刷中). (1997)
[Publications] Hammer,M.F.,Horai,S.,etal.: "Y chromosome evidence for multiple human dispersals involving Africa," Genetics. (印刷中). (1997)
[Publications] Murata,S.,Okada,N.,etal.: "Details of retropositional genome dynamics that provide a rational for a generic division : The distinct branching of all the Pacific salmon and trout(Oncorhynchus) from the Atlantic salmon and traut(Salmo)," Genetics. 142. 915-926 (1996)
[Publications] Ohshima,K.,Okada,N.,etal.: "The 3'ends of tRNA-derived short interspersed repetitive elements are derived from the 3'ends of long interspersed repetitive elements." Mol.Cel.Biol.16. 3756-3764 (1996)
[Publications] Okada,N.,Hamada,M: "The 3'ends of tRNA-derived SINEs originated from the 3"ends of LINEs : A new example from the bovine genome." J,Mol,Evol,. (印刷中). (1997)
[Publications] Hamada,M.,Hasegawa,M.,Okada,N.,etal.: "Characterization of newly isolated family of short interspersed repetitive elements(SINEs) in coregonid fish(whitofish) with sequences that are almost identical to those of the Sma I family of refeats : possible evidence for the horizontal transfer of SINEs." Genetics. (印刷中). (1997)
[Publications] Takasaki,N.,Okada,N.,etal.: "Characterization of the salmon Sma I family of SINEs : interspecific and intraspecific polymorhism of the insertion of SINEs in the genomes of chum and pink salmon." Genetics. (印刷中). (1997)
[Publications] Koga,A.,Hori,H.,etal.: "Transposable element in fish." Nature. 383. 30-30 (1996)
[Publications] Ingaki,Y.,Hori,H.,etal.: "Cloning of the Mycoplasma capricolum gene encoding chain release factor." Gene. 169. 101-103 (1996)
[Publications] Bessho,Y.,Hori,H.,etal.: "Planarian mtDNA and reproductive mode." Mol.Ecol.6. 129-136 (1997)
[Publications] Kurosaki,K.,Ueda,S.,etal.: "A 3-bp deletion polymorphism adjacent to a tetranucleotide repeat poly morphism at the CYP19 locus." Jpn.J,Legal Med.(印刷中). (1997)
[Publications] Watanabe,Y.,Ueda,S.,etal.: "No directionality of STR evolution at the HPRT locus in catarrhine primates." Folia Primatologica. (印刷中). (1997)
[Publications] Sumiyama,K.,Ueda,S.,etal.: "Class III POU genes : generation of homopolymeric amino acid repeats under GC pressure in mammals." J,Mol.Evol.43(3). 170-178 (1996)
[Publications] Tanabe,H.,Ueda,S.,etal.: "Molecular anatomy of human chromosome 9 : comparative mapping of the immunoglobulin processed pseudogene Cε3 (IGHEP2) in primates." Cytogenet.Cell Genet. 73(1/2). 92-96 (1996)
[Publications] Watanabe,Y.,Ueda,S.,etal.: "Short tandem repeat polymorphisms in Japanese macaques : their short repeat length and low informativeness." Mammal.Genome. 7(5). 383-385 (1996)
[Publications] Kurosaki,K.,Ueda,S.,etal.: "Sequence variation found in the flanking region of a trimeric short tandem repeat at the PLA2 locus : its considerable effect onestimating alleles." Jpn,J,Legal Med.50(1). 1-5 (1996)
[Publications] Iwabe,N.,Kuma,K.,Miyata,T.: "Evolution of gene families and relationship with organismal evolution." Mol.Biol.Evol.13. 483-493 (1996)
[Publications] Nikoh,N.,Miyata,T.,etal.: "An estimate of divergence time of Parazoa and Eumetazoa and that of Cephalochordata and Vertebrata by aldolase and triose phosphate isomerase clocks." J,Mol.Evol.(印刷中). (1997)
[Publications] Inoue,T.,Miyata,T.,etal.: "Caenorhabditis elegans has two isozymic forms CE-1 and CE-2 of fructose-1,b-biophosphate alddase which are encoded by different genes." Archives Biochem.Biophys. (印刷中). (1997)
[Publications] Yasojima,K.,Miyata,T.,etal.: "Cloning of human and mouse cDNAs encoding novel zinic finger proteins expressed in cerebellum and hippocampus." Biophys.Biochem.Res.Commun.(印刷中). (1997)
[Publications] Sasaki,T.,Ishikawa,H.,etal.: "Nitrogen recycling in the brown planthopper,Nilaparvatalugens: Involvement of yeast-like endosymbiorits in uric acid metabolism." J. Insect Physiol.42. 125-129 (1996)
[Publications] Harada,H.,Ishikawa,H.,etal.: "A consideration about the origin of aphid intracellular symbiont in connection with gut bacterialflora." J.Gen.Appl.Microbiol.42. 17-26 (1996)
[Publications] Kanaki,K.,Ishikawa,H.,etal.: "A characteristic difference among GroEL homologs from intracellular symbionts of closely interrelated species of aphid." Zoological Sci.13. 320-323 (1996)
[Publications] Fukatsu,T.,Ishikawa,H.,etal.: "Phylogenetic position of yeast-like symbiorit of Hamiltonaphis slyraci(Homoptera,Aphididae) based on 18S rDNA sequence." Zoological Sci.13. 320-323 (1996)
[Publications] Aoki,S.,Ishikawa,H.,etal.: "Secondary monoecy of the gall aphid Thecabius populimorilis(Homoptera)." Jpn.J.Entomol.64. 367-378 (1996)
[Publications] Ishikawa,H: "Intracellular symbiosis in insects. In Microbial Diversity in Time and Spase,eds." Plenum Press,New York.93-100 (1996)
[Publications] Amako,D.,Ishikawa,H.,etal.: "Nucleotide sequence and presumed seondary structure of the 28S rRNA of pea aphid: Implication for diversification of insect rRNA." J.Mol.Evol.43. 469-475 (1996)
[Publications] Sato,S.,Ishikawa,H: "Cloning and sequencing of gene for a periplasmic 5.4kDa peptide of the macronuleus specific symbiont Holospora obtusa of the ciliate Paramecium caudafun." Zoological Sci.(印刷中). (1997)
[Publications] Morioka,M.,Ishikawa,H: "Insect chaperonin 60(symbionin)" Methods Enzymol.,Academic Press,New York,. (印刷中). (1997)
[Publications] Yamamoto,H.,Gojobori,T.,etal.: "Regulatory regions of vertebrate tyrosinase genes: Divergence functional conservation." Proc,Natl,Acad,Sci,U.S.A.(印刷中). (1997)
[Publications] Mizokami,M.,Gojobori,T.,etal.: "Constrained evolution of hepatitis Bvirus with overlapping genes." J.Mol.Evol.(印刷中). (1997)
[Publications] Watanabe,H.,Gojobori,T.,etal.: "Genome plasticity as a paradigm of eubacteria evolution." J.Mol.Evol.(印刷中). (1997)
[Publications] Tateno,Y.,Gojobori,T.,etal.: "Evolutionary motif and its biological and structural significance." J.Mol.Evol.(印刷中). (1997)
[Publications] Yamaguchi,Y.,Gojobori,T: "Evolutionary mednanisms and population dynamics of the third variable envelope region of HIV within single hosts." Proc.Natl.Acad.Sci.U.S.A. 94. 1264-1269 (1997)
[Publications] Perriere,G.,Gojobori,T.,etal.: "The NRSub database : update 1997." Nucl,Acids Res.25(1). (1997)
[Publications] Tateno,Y.,Gojobori,T.,etal.: "DNA data bank of Japan in the age of information biology." Nucl,Acids Res.25(7). 14-17 (1997)
[Publications] Perriere,G.,Gojobori,T.,etal.: "NRSub: a non-redundant database for Bacillus subtilis." Nucl,Acids Res.24(1). 41-45 (1996)
[Publications] Ohba,T.,Gojobori,T.,etal.: "Evolutionary relationship of hepatitis C, pesti-,flavi-,plantviruses,and newly discovered GB hepatitis agents." FEBS Lett.378. 232-234 (1996)
[Publications] Endo,T.,Gojobori,T.,etal.: "Large-scale search for genes on which positive selection may operate." Mol.Biol.Evol.13(5). 685-690 (1996)
[Publications] Fumihito,A.,Gojobori,T.,etal.: "Monophyletic origin and unique dispersal patterns of domestic fowls." Proc.Natl.Acad.Sci.U.S.A.93(13). 6792-6795 (1996)
[Publications] Shiga,H.,Gojobori,T.,etal.: "Identification of multiple HiV-1 cytotoxic T-cell epitopes presented by human leukocyte antigen B35 molecules." AiDS. 10. 1075-1083 (1996)

1996 Fiscal Year Annual Research Report

分子進化学の新展開

Principal Investigator

長谷川 政美 統計数理研究所, 予測制御研究系, 教授 (60011657)

Research Products

[Publications] Cao,Y.,Okada,N.,Hasegawa,M.: "Phylogenetic position of guinea-pigs revisited" Mol.Biol.Evol.(印刷中). (1997)

[Publications] Hasegawa,M.,Adachi,J.,et al.: "Novel phylogeny of whales supported by total molecular evidence." J,Mol,Evol.(印刷中). (1997)

[Publications] Aoshima,M.,Hasegawa,M.,et al.: "Cloning and seguencing of a gene encoding 16S ribosomal RNA from a novel hyperthemophilic archaebacterium NC12." Gene,. (印刷中). (1996)

[Publications] Hasegawa,M.,Fitch,W.M: "Dating the cenancestor of organisms" Science. 274. 1750-1750 (1996)

[Publications] Milinkovitch,M,C.,Hasegawa,M.,et al: "Effects of character weighting and species sampling on phylogeny reconstruction : a case" Genetics. 144. 1817-1833 (1996)

[Publications] Kamaishi,T.,Hasegawa,M.,etal.: "Complete nucleotide sequences of the gene encoding translation elongation factors 1alpha and 2 from a microsporidian parasite,Glugea plecoglossi : implications for the deopest branching of eukaryotes." J,Biochem. 120. 1095-1103 (1996)

[Publications] Hashimoto,T.,Hasegawa,M: "Origin and early evolution of eukaryotes inferred from the amino acidsequences of translation elongation factors 1alpha / Tu and 2/G." Adv,Biophy. 32. 73-120 (1996)

[Publications] Adachi,J.,Hasegawa,M: "MOLPHY Version 2.3 : Programs for Molecular Phylogenetics Based on Maximun Likelihood." Computer Science Monographs.28. 1-150 (1996)

[Publications] Kamaishi,T.,Hasegawa,M.,etal.: "Protein phylogeny of EF-1alpha suggests microsporidians are extremelyancient eukaryotes." J,Mol,Evol.,. 42. 257-263 (1996)

[Publications] Hasegawa,M.,Adachi,J: "Phylogenetic postion of cetaceans relative to artiodactyls : Reanalysis of mitochondrial and nuclear sequences." Mol.Biol.Evol.13. 710-717 (1996)

[Publications] Adachi,J.,Hasegawa,M: "Model of amino acid substitution in proteins encoded by mitochondrial DNA." J,Mol.Evol.42. 459-468 (1996)

[Publications] Nakamura,Y.,Hasegawa,M.,et al.: "Phylogenetic place of kinetoplastid protozoa inferred from protein phylogenies of elongation factors 1alpha and 2." J,Biochem.119. 70-79 (1996)

[Publications] Horai,S.,etal.: "DNA polymorphism in East Asian populations, with special reference tothe peopling of Japan." Am.J.Hum.Genet.59. 579-590 (1996)

[Publications] Hayasaka,K.,Fujii,K. and Horai,S: "Molecular phylogeny of macaques : implications of nucleotide sequences from an 896 base pair region of mitochondrial DNA." Mol.Biol.Evol.13. 1044-1053 (1996)

[Publications] Goto,Y.,Horai,S.,etal.: "Detection of DNA fragments encompassing the deletion junction of mitochondrial genome." Biochem.Biophy.Res.Commun.222. 215-219 (1996)

[Publications] Nishino,I.,Horai,S.,etal.: "A novel mutation in the mitochondrial tRNAThr gene associated with a mitochondrial encephalomyopathy." Biochem.Biophy.Res.Commun.225. 180-185 (1996)

[Publications] Nishino,I.,Horai,S.,etal.: "The 3260 mutation in mitochondrial DNA can cause mitochondrial myopathy,encephalopaty,lactic acidosis,and stroke-like episodes(MELAS)." Muscle & Nerve. 19. 1603-1604 (1996)

[Publications] Muraki,K.,Horai,S.,etal.: "Severe lactic acidosis and neonatal death in Pearson syndrome." J.Inher.Metab.Dis. (印刷中). (1997)

[Publications] Blagitko,N.,Horai,S.,etal.: "Pelymorphism of the HLA-DRB1 locus in Colombian,Ecuadorian,and Chilean Amerinds." Human Immunology.(印刷中). (1997)

[Publications] Hammer,M.F.,Horai,S.,etal.: "Y chromosome evidence for multiple human dispersals involving Africa," Genetics. (印刷中). (1997)

[Publications] Murata,S.,Okada,N.,etal.: "Details of retropositional genome dynamics that provide a rational for a generic division : The distinct branching of all the Pacific salmon and trout(Oncorhynchus) from the Atlantic salmon and traut(Salmo)," Genetics. 142. 915-926 (1996)

[Publications] Ohshima,K.,Okada,N.,etal.: "The 3'ends of tRNA-derived short interspersed repetitive elements are derived from the 3'ends of long interspersed repetitive elements." Mol.Cel.Biol.16. 3756-3764 (1996)

[Publications] Okada,N.,Hamada,M: "The 3'ends of tRNA-derived SINEs originated from the 3"ends of LINEs : A new example from the bovine genome." J,Mol,Evol,. (印刷中). (1997)

[Publications] Takasaki,N.,Okada,N.,etal.: "Characterization of the salmon Sma I family of SINEs : interspecific and intraspecific polymorhism of the insertion of SINEs in the genomes of chum and pink salmon." Genetics. (印刷中). (1997)

[Publications] Koga,A.,Hori,H.,etal.: "Transposable element in fish." Nature. 383. 30-30 (1996)

[Publications] Ingaki,Y.,Hori,H.,etal.: "Cloning of the Mycoplasma capricolum gene encoding chain release factor." Gene. 169. 101-103 (1996)

[Publications] Bessho,Y.,Hori,H.,etal.: "Planarian mtDNA and reproductive mode." Mol.Ecol.6. 129-136 (1997)

[Publications] Kurosaki,K.,Ueda,S.,etal.: "A 3-bp deletion polymorphism adjacent to a tetranucleotide repeat poly morphism at the CYP19 locus." Jpn.J,Legal Med.(印刷中). (1997)

[Publications] Watanabe,Y.,Ueda,S.,etal.: "No directionality of STR evolution at the HPRT locus in catarrhine primates." Folia Primatologica. (印刷中). (1997)

[Publications] Sumiyama,K.,Ueda,S.,etal.: "Class III POU genes : generation of homopolymeric amino acid repeats under GC pressure in mammals." J,Mol.Evol.43(3). 170-178 (1996)

[Publications] Tanabe,H.,Ueda,S.,etal.: "Molecular anatomy of human chromosome 9 : comparative mapping of the immunoglobulin processed pseudogene Cε3 (IGHEP2) in primates." Cytogenet.Cell Genet. 73(1/2). 92-96 (1996)

[Publications] Watanabe,Y.,Ueda,S.,etal.: "Short tandem repeat polymorphisms in Japanese macaques : their short repeat length and low informativeness." Mammal.Genome. 7(5). 383-385 (1996)

[Publications] Kurosaki,K.,Ueda,S.,etal.: "Sequence variation found in the flanking region of a trimeric short tandem repeat at the PLA2 locus : its considerable effect onestimating alleles." Jpn,J,Legal Med.50(1). 1-5 (1996)

[Publications] Iwabe,N.,Kuma,K.,Miyata,T.: "Evolution of gene families and relationship with organismal evolution." Mol.Biol.Evol.13. 483-493 (1996)

[Publications] Nikoh,N.,Miyata,T.,etal.: "An estimate of divergence time of Parazoa and Eumetazoa and that of Cephalochordata and Vertebrata by aldolase and triose phosphate isomerase clocks." J,Mol.Evol.(印刷中). (1997)

[Publications] Inoue,T.,Miyata,T.,etal.: "Caenorhabditis elegans has two isozymic forms CE-1 and CE-2 of fructose-1,b-biophosphate alddase which are encoded by different genes." Archives Biochem.Biophys. (印刷中). (1997)

[Publications] Yasojima,K.,Miyata,T.,etal.: "Cloning of human and mouse cDNAs encoding novel zinic finger proteins expressed in cerebellum and hippocampus." Biophys.Biochem.Res.Commun.(印刷中). (1997)

[Publications] Sasaki,T.,Ishikawa,H.,etal.: "Nitrogen recycling in the brown planthopper,Nilaparvatalugens: Involvement of yeast-like endosymbiorits in uric acid metabolism." J. Insect Physiol.42. 125-129 (1996)

[Publications] Harada,H.,Ishikawa,H.,etal.: "A consideration about the origin of aphid intracellular symbiont in connection with gut bacterialflora." J.Gen.Appl.Microbiol.42. 17-26 (1996)

[Publications] Kanaki,K.,Ishikawa,H.,etal.: "A characteristic difference among GroEL homologs from intracellular symbionts of closely interrelated species of aphid." Zoological Sci.13. 320-323 (1996)

[Publications] Fukatsu,T.,Ishikawa,H.,etal.: "Phylogenetic position of yeast-like symbiorit of Hamiltonaphis slyraci(Homoptera,Aphididae) based on 18S rDNA sequence." Zoological Sci.13. 320-323 (1996)

[Publications] Aoki,S.,Ishikawa,H.,etal.: "Secondary monoecy of the gall aphid Thecabius populimorilis(Homoptera)." Jpn.J.Entomol.64. 367-378 (1996)

[Publications] Ishikawa,H: "Intracellular symbiosis in insects. In Microbial Diversity in Time and Spase,eds." Plenum Press,New York.93-100 (1996)

[Publications] Amako,D.,Ishikawa,H.,etal.: "Nucleotide sequence and presumed seondary structure of the 28S rRNA of pea aphid: Implication for diversification of insect rRNA." J.Mol.Evol.43. 469-475 (1996)

[Publications] Sato,S.,Ishikawa,H: "Cloning and sequencing of gene for a periplasmic 5.4kDa peptide of the macronuleus specific symbiont Holospora obtusa of the ciliate Paramecium caudafun." Zoological Sci.(印刷中). (1997)

[Publications] Morioka,M.,Ishikawa,H: "Insect chaperonin 60(symbionin)" Methods Enzymol.,Academic Press,New York,. (印刷中). (1997)

[Publications] Yamamoto,H.,Gojobori,T.,etal.: "Regulatory regions of vertebrate tyrosinase genes: Divergence functional conservation." Proc,Natl,Acad,Sci,U.S.A.(印刷中). (1997)

[Publications] Mizokami,M.,Gojobori,T.,etal.: "Constrained evolution of hepatitis Bvirus with overlapping genes." J.Mol.Evol.(印刷中). (1997)

[Publications] Watanabe,H.,Gojobori,T.,etal.: "Genome plasticity as a paradigm of eubacteria evolution." J.Mol.Evol.(印刷中). (1997)

[Publications] Tateno,Y.,Gojobori,T.,etal.: "Evolutionary motif and its biological and structural significance." J.Mol.Evol.(印刷中). (1997)

[Publications] Yamaguchi,Y.,Gojobori,T: "Evolutionary mednanisms and population dynamics of the third variable envelope region of HIV within single hosts." Proc.Natl.Acad.Sci.U.S.A. 94. 1264-1269 (1997)

[Publications] Perriere,G.,Gojobori,T.,etal.: "The NRSub database : update 1997." Nucl,Acids Res.25(1). (1997)

[Publications] Tateno,Y.,Gojobori,T.,etal.: "DNA data bank of Japan in the age of information biology." Nucl,Acids Res.25(7). 14-17 (1997)

[Publications] Perriere,G.,Gojobori,T.,etal.: "NRSub: a non-redundant database for Bacillus subtilis." Nucl,Acids Res.24(1). 41-45 (1996)

[Publications] Ohba,T.,Gojobori,T.,etal.: "Evolutionary relationship of hepatitis C, pesti-,flavi-,plantviruses,and newly discovered GB hepatitis agents." FEBS Lett.378. 232-234 (1996)

[Publications] Endo,T.,Gojobori,T.,etal.: "Large-scale search for genes on which positive selection may operate." Mol.Biol.Evol.13(5). 685-690 (1996)

[Publications] Fumihito,A.,Gojobori,T.,etal.: "Monophyletic origin and unique dispersal patterns of domestic fowls." Proc.Natl.Acad.Sci.U.S.A.93(13). 6792-6795 (1996)

[Publications] Shiga,H.,Gojobori,T.,etal.: "Identification of multiple HiV-1 cytotoxic T-cell epitopes presented by human leukocyte antigen B35 molecules." AiDS. 10. 1075-1083 (1996)

長谷川政美統計数理研究所, 予測制御研究系, 教授 (60011657)