1997 Fiscal Year Annual Research Report

がんの生物学的特性の研究の総括

Research Project

Project/Area Number	06281104
Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Research Institution	Showa University
Principal Investigator	黒木登志夫昭和大学, 腫瘍分子生物学研究所, 所長 (90006073)
Co-Investigator(Kenkyū-buntansha)	渋谷正史東京大学, 医科学研究所, 教授 (10107427) 月田承一郎広島大学, 医学部, 教授 (50155347) 笹月健彦九州大学, 生医研, 教授 (50014121) 田原栄一広島大学, 医学部, 教授 (00033986) 高井義美大阪大学, 医学部, 教授 (60093514) 菅村和夫東北大学, 医学部, 教授 (20117360)
Keywords	細胞増殖 / 細胞分化 / 細胞死 / シグナル伝達 / 細胞間相互作用 / がん転移 / ヒトがん / がん遺伝子
Research Abstract	1.がんの生物学的特性を明らかにすることは、がんの診断、治療のための最も基本的な事項である。総括班は次の5項目について研究を計画をし、研究が進展するよう調整した。 (1)細胞の増殖・分化、細胞死 (2)細胞の構造と機能 (3)細胞間相互作用 (4)浸潤・転移 (5)ヒトがんの特性平成9年度「がん生物」領域には総括班と92の研究班が成立した。平成9年度からは研究(1)公募がなくなり研究(1)は計画のみとなった。予算の約50%は研究(1)に、68%が計画研究に配分されたことになる。班数の50%はA01.「細胞の増殖・分化・細胞死」に関するものであった。 2.平成10年度計画班として研究(1)2班(研究項目;シグナル伝達、胃がん遺伝子)、研究(2)4班(研究項目;細胞分化、増殖因子、がん抑制遺伝子)を設定した。

Research Products
(7 results)

All Other

All Publications (7 results)

[Publications] Kashiwagi,M: "Specific inhibition of hair follicle formation by epidermal growth factor in an organ culture of developing mouse skin." Develop.Biol.189. 22-32 (1997)
[Publications] Takeshita,T.: "STAM,signal transducing adaptor molecule is associated with Janus kinases and involved in signaling for cell growth and c-myc induction." Immunity. 6. 449-457 (1997)
[Publications] Takahashi,T.: "The 230kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLCg pathway and partially induces mitotic signals in NIH3T3 fibroblasts." Oncogene. 14. 2079-2089 (1997)
[Publications] Takaishi,K.: "Regulation of cell-cell adhesion by Rac and Rho small G proteins in MDCK cells." J.Cell Biol.139. 1047-1059 (1997)
[Publications] Sakakibara,A.: "Possible involvement of phosphorylation of occludin in tight junction formation." J.Cell Biol.137. 1393-1401 (1997)
[Publications] Kuniyasu,H.: "Growth inhibitory effect of interferon-β is associated with the induction of cyclin-dependent kinase inhibitor p27Kip1 in a human gastric carcinoma cell line." Cell Growth & Differentiation. 8. 47-52 (1997)
[Publications] Ohmori,M.: "Acitvated Ki-ras enhances sensitivity of ceramide-induced apoptosis without c-Jun NH2-terminal kinase/stress-activated protein kinase or extracellular signal-regulated kinase activation in human colon cancer cells." Cancer Research. 57. 4714-4717 (1997)

1997 Fiscal Year Annual Research Report

がんの生物学的特性の研究の総括

Principal Investigator

黒木 登志夫 昭和大学, 腫瘍分子生物学研究所, 所長 (90006073)

Research Products

[Publications] Kashiwagi,M: "Specific inhibition of hair follicle formation by epidermal growth factor in an organ culture of developing mouse skin." Develop.Biol.189. 22-32 (1997)

[Publications] Takeshita,T.: "STAM,signal transducing adaptor molecule is associated with Janus kinases and involved in signaling for cell growth and c-myc induction." Immunity. 6. 449-457 (1997)

[Publications] Takahashi,T.: "The 230kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLCg pathway and partially induces mitotic signals in NIH3T3 fibroblasts." Oncogene. 14. 2079-2089 (1997)

[Publications] Takaishi,K.: "Regulation of cell-cell adhesion by Rac and Rho small G proteins in MDCK cells." J.Cell Biol.139. 1047-1059 (1997)

[Publications] Sakakibara,A.: "Possible involvement of phosphorylation of occludin in tight junction formation." J.Cell Biol.137. 1393-1401 (1997)

[Publications] Kuniyasu,H.: "Growth inhibitory effect of interferon-β is associated with the induction of cyclin-dependent kinase inhibitor p27Kip1 in a human gastric carcinoma cell line." Cell Growth & Differentiation. 8. 47-52 (1997)

[Publications] Ohmori,M.: "Acitvated Ki-ras enhances sensitivity of ceramide-induced apoptosis without c-Jun NH2-terminal kinase/stress-activated protein kinase or extracellular signal-regulated kinase activation in human colon cancer cells." Cancer Research. 57. 4714-4717 (1997)

黒木登志夫昭和大学, 腫瘍分子生物学研究所, 所長 (90006073)