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1997 Fiscal Year Final Research Report Summary

Mechanisms for Cooling the Brain Selectively and Hemodynamics of Emissary Venins

Research Project

Project/Area Number 06404018
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionKanazawa University

Principal Investigator

NAGASAKA Tetsuo  Kanazawa University, Sch.of Med., Prof., 医学部, 教授 (80023646)

Co-Investigator(Kenkyū-buntansha) TANABE Minoru  Hokkaido University, College of Med.Tech.Associate Prof., 医療技術短大, 助教授 (20217110)
HIRASHITA Masami  Kanazawa College of Economics, Prof., 教授 (30102007)
SUGIMOTO Naotoshi  Kanazawa University, Sch.of Med., Instructor, 医学部, 助手 (80272954)
SAKURADA Sohtaro  Kanazawa University, Sch.of Med., Assistant Prof., 医学部, 講師 (00215691)
SHIDO Osamu  Kanazawa University, Sch.of Med., Associate Prof., 医学部, 助教授 (40175386)
Project Period (FY) 1994 – 1997
KeywordsHyperthermia / Selective Brain Cooling / Emissary Venous Flow / Posture / Intrathoraci Pressure / Ventilatory Volume
Research Abstract

The purpose of this study was to investigate how the efficiency of selective brain cooling mechanisms in humans are influenced by the change in emissary venous flow due to the change in posture, intrathoracic pressure and ventilation. 1. Compared with in supine body position, emissary flow was higher and tympanic temperature became lower in upright position. With 6゚-head down position, the changes were in opposite directions. 2. While occuluding the angular vein of one side and the facial vein at the alinasal level of another side, there occurred a disrepancy of tympanic temperatures in both sides, higher in the side where the angular vein was occluded. 3. In a negative breathing through a respirator with an inspiratory resistance or through a tank whose pressure was maintained negative, emissary flows increased and tympanic temperature became lower compared with the controls. 4. With hyperventilation, tympanic temperature became lower. The was observed when CO_2-added air was inspired, but the effect was not consistent in this case. 5. When the subject breathed through a nostril of one side, that of the other side was kept obstructed, the ipsilateral tympanic temperature became slightly lower. All these results suggest that enhancement of emissary venous flow was necessary important to increase efficiency of selective brain cooling in humans during hyperthermia.

  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] Nagasaka T: "Selective barain cooling in hyperthermia:The mechanisms and medical implications." Medical Hypotheses. 50巻(January issue). (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nagasaka T: "Influence of changing intrathoracic pressure on emissary venous flow and selective brain cooling in hyperthermic conditions" Biometeorology 14(slovenia). 2-2. 325-332 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tanabe M: "Lower body negative pressure suppresses aweatint rate in hyperthermic subiects." Biometeorology 14(slovenia). 2-2. 341-345 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 田辺 実: "化粧が高温環境下の発汗反応及び選択的脳冷却機構に及ぼす影響" コスメトロジー研究報告. 4. 122-129 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 永坂 鉄夫: "動静脈吻合の体力医学的意義" デサントスポーツ科学. 8. 3-13 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sakurada S: "A role for gastrointestinal endotoxins in enhancement of heat tolerance by physical fitness" J Appl Physiol. 84. 207-214 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 永坂 鉄夫: "Human Selective Brain Cooling (訳)" 金沢熱中症研究会, 87 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nagasaka T: "Selective brain cooling in hyperthermia : The mechanisms and medical implications." Medical Hypotheses. 50. (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagasaka T: "Influence of changing intrathoracic pressure on emissary venous flow and selective brain cooling in hyperthermic conditions" Biometeorology. 14 (Slovenia), Part 2 (vol.2). 325-332 (1957)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagasaka T: "Thermoregulatory changes in humans and animals acclimated to heat given for hours at a fixed time daily." Proc.Inddor Air '96, Nagoya. 4. 255-258 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tanabe M: "Lower body negative pressure suppresses sweating rate in hyperthermic subjects." Biometeorology. 14 (slovenia), Part 2 (vol.2). 341-345 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tanabe M: "Changes in intrathoracic pressure affect the efficiency of selective." Jpn J Physiol. 46 (suppl). S204 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Romanovsky AA: "Endotoxin schok : thermoregulatory mechanisms." Am J Physiol. 270. R693-R703 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakurada S.: "Arole for gastrointestinal endotoxins in enhancement of heat rolerance by physical fitness." J Appl Physiol. 84. 207-214 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hagasaka T: "Human Selective Brain Cooling by M.Cabanca (translation)" Kanazawa-Nechusho-Kenkyukai. 87. (1997)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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