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1995 Fiscal Year Final Research Report Summary

Bone remodeling at the interface with biomaterials

Research Project

Project/Area Number 06404053
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

OKA Masanori  Kyoto Univ., Research Center for Biomedical Eng.Professor, 生体医療工学研究センター, 教授 (20088537)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Takashi  Kyoto Univ., Faculty of Medicine Professor, 医学研究科, 教授 (10201675)
TSUTSUMI Sadami  Kyoto Univ., Research Center for Biomedical Eng.Professor, 生体医療工学研究センター, 教授 (00028739)
Project Period (FY) 1994 – 1995
KeywordsBone / Remodeling / Biomaterials / Interface / FEM / stress / Wolff's law
Research Abstract

Bone formation and remodeling around implanted materials are influenced by the kinds of materials, surface properties of the materials, anatomical sites of implantation, and the load-bearing condition. In this study, three kinds of materials were implanted into the femoral condyles of dogs, and bone formation and remodeling were observed for 6 months. Uniform thickening of lamellar bones was observed around bead-coated alumina while thick fibrous tissues surrounded by corticalized bones formed around smooth alumina. This distinct difference in remodeling pattern was subjected to mechanical simulation by using finite-element analysis (FEA) . Although stress distribution around bead-coated alumina simulates the bone density, the remodeling pattern around an uncoated implant could not be determined by the stress. To describe the latter remodeling pattern, it is necessary to analyze the strain surrounding the implants.

  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] 岡正典: "三次元FEM解析による股関節の負荷機構に関する研究" 生体材料. 12. 173-183 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岡正典: "海綿骨の衝撃吸収" THE BONE. 8. 71-86 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岡正典: "インプラント周囲の骨リモデリングに関する研究" 日本臨床バイオメカニクス学会誌. 15. 467-475 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岡正典: "超高速カメラによる関節の衝撃吸収機構の可視化(第2報)" 日本臨床バイオメカニクス学会誌. 15. 169-174 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M. Oka: "Changes in joint fluid after total arthroplasty" Clin. Orthop.307. 240-249 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岡正典: "海綿骨骨梁構造の力学的特性と関節における機能" 日本臨床バイオメカニクス学会誌. 15. 157-162 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M. Oka: "Bone remodeling around implanted materials" Clinical Biomechanics. 124-137 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M. Oka: "The energy-absorbing function cancellous bone" Clinical Biomechanics. 138-152 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y. Chang: "Bone formation and remodeling around implanted materials under load bearing conditions" Clin. Mat. 17. 181-187 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y. Chang: "Significance of interstitial bone ingrowth under load-bearing conditions" 日整会誌. 69. 1661 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岡正典: "関節軟骨のバイオメカニクス" 臨床リウマチ. 7. 60-81 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M. Oka: "Bone remodeling around implanted ceramics" Bioceramics. 8. 103-106 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S. Hanafusa: "Biodegadable plate fixation of rabbit femoral shaft osteotomies" Clin. Orthop. R. R.315. 262-271 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T. Kitsugi: "Influence of Disodium (1-Hydroxhylidene) diphosphonate on bone ingrowth into porous titanium fiber-mesh implonts" The Journal of Arthroplasty. 10. 245-253 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T. Nakamura: "In vitro effects of EHDP on the foramtion and osteoclstic absorption of bone-like apatite formed on bioactive ceramics" Bioceramics. 8. 23-27 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岡正典: "人工骨軟骨複合材料の開発" 学術月報. 48. 96 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Oka: "Changes in joint fluid after total arthroplasty." Clin.Orthop.307. 240-249 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Oka: "Bone remodeling around implanted materials." Clinical Biomechanics. 124-137 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Oka: "The energy-absorbing function of cancellous bone." Clinical Biomechanics. 138-152 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Chang: "Bone formation and remodeling around implanted materials under load bearing conditions." Clin.Mat.17. 181-187 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Chang: "Significance of interstitial bone ingrowth under load-bearing conditions." J.Japanese Orthop.ass.69. 1661 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Oka: "Bone remodeling around implanted ceramics." Bioceramics. 8. 103-106 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Hanafusa: "Biodegradable plate fixation of rabbit femoral shaft osteotomies." Clin.Orthop.R.R.315. 262-271 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Kitsugi: "Influence of Disodium (1-Hydroxythylidene) diphosphonate on bone ingrowth into porous titanium fiber-mesh implants." The Journal of Arthroplasty. 10. 245-253 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Nakamura: "In vitro effects of EHDP on the formation and osteoclastic absorption of bone-like apatite formed on bioactive ceramics." Bioceramics. 8. 23-27 (1995)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1997-03-04  

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