1995 Fiscal Year Final Research Report Summary
Endocrinological and thermal effects on alpha_1-adrenergic-receptor-mediated contraction of the prostate.
| Project/Area Number |
06404057
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | University of Tokyo |
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Principal Investigator |
KAWABE Kazuki The Univ.of Tokyo, Urology, Professor, 医学部(病), 教授 (20124670)
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| Co-Investigator(Kenkyū-buntansha) |
MORIYAMA Nobuo The Univ.of Tokyo, Urology, Assistant Prof., 医学部(病), 講師 (80143501)
HOMMA Yukio The Univ.of Tokyo, Urology, Assistant Prof., 医学部(病), 講師 (40165626)
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| Project Period (FY) |
1994 – 1995
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| Keywords | Benign prostatic hyperplasia / laser / androgen / alpha_1-adrenergic receptor |
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| Research Abstract |
The contraction of the prostate induced by alpha_1-adrenergic receptor agonist was examined in regards to the possible changes in properties when exposed to endocrinological and thermal stimuli. Thermal effects by laser irradiation induced little changes in contraction force and Kd and Bmax of alpha_1-adrenergic receptor of the human prostate. Castrated rat prostate was used as the model to examine the possible changes of the receptor by androgen deprivation. The contraction force per a unit weight of the prostate was two to three-fold increased by castration, whilst the binding assay between prazosin and receptor and inhibition assay competed by prazosin or phenylephrine showed no essential changes in receptor properties. These results indicate that alpha_1-adrenergic receptor is little affected by endocrionological and thermal interventions. The clinical implications of these characters of alpha_1-adrenergic receptor of the prostate warrant further studies.
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