1996 Fiscal Year Final Research Report Summary
Role of BMPs in differentiation process of osteoblasts, chondrocytes and muscle cells
| Project/Area Number |
06404064
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (A)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Morphological basic dentistry
|
|---|
| Research Institution | Showa University |
|---|
Principal Investigator |
YOSHIKI Susaku School of Dentistry, Showa University, Professor, 歯学部, 教授 (30085740)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KATAGIRI Takenobu School of Dentistry, Showa University, Assistant, 歯学部, 助手 (80245802)
TAKAHASHI Naoyuki School of Dentistry, Showa University, Associate Professor, 歯学部, 助教授 (90119222)
SUDA Tatsuo School of Dentistry, Showa University, Professor, 歯学部, 教授 (90014034)
YAMAGUCHI Akira School of Dentistry, Showa University, Associate Professor, 歯学部, 助教授 (00142430)
|
|---|
| Project Period (FY) |
1994 – 1996
|
| Keywords | ostepblast / chondrocyte / myoblast / BMP / Hedgehog |
|---|
| Research Abstract |
1) BMP-2 stimulated osteoblastic differentiation in ST2, C3H10T1/2, MC3T3-E1 and PA6 cells, but its effect was less potent in PA6 cells compared with other cell lines.
2) BMP-2 induced chondrocyte differentiation in C3H10T1/2 cells, but not in ST2, MC3T3-E1 and PA6 cells.
3) BMP-2 inhibited myogenic differentiation in C2C12 myoblasts by suppressing transcription of myogenin. BMP-2 also induced osteoblastic differentiation in this cell line.
4) Sonic hedgehog induced osteoblast differentiation in C3H10T1/2 and MC3T3-E1 cells.
5) Transplantation of fibroblasts expressing Sonic hedgehog into muscle in athymic mice induced ectopic bone formation.
|
