1995 Fiscal Year Final Research Report Summary
Physiological role of IGF-I in the nutrition of central nervous system
| Project/Area Number |
06454082
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
食品科学・栄養科学
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NOGUCHI Tadashi The University of Tokyo, Professor, 農学部, 教授 (50011937)
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| Project Period (FY) |
1994 – 1995
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| Keywords | IGF-I / IGF-II / IGF-binding protein / Protein nutrition / Insulin-like growth factor |
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| Research Abstract |
To elucidate the physiological role of IGF-I in the nutrition of central nervous system, the following studies were performed.
(1) Relate the effect of nutrition of the expressioin of IGF-I,IGF-II and IGF-binding protein genes to the mode of nutrient incorporation by the central nervous.
(2) Elucidate the role of nervous system in the nutrition of tissues.
Gene expression of IGF-I,IGF-II and IGF-binding prteins was studied in various portions of rat brain. IGF-I mRNA was found in various portions of brain but it was scarcely found in cerebrum and not so much in cerebellum and midbrain. On the other hand, IGF-II mRNA was found in every portion of brain. Among IGFBP-1 BP-2 and BP-3, only IGFBP-2 mRNA was found in brain extensively. Dictary protein did not affect the mRNA contents of IGF-I,IGF-II and IGFBP-2 in brain, probably reflecting the conservative nature of brain nutrition. It was suggested that brain nutrition is regulated not by endocrine mode of IGF-I action but by autocrine/paracrine mode of IGF-I action.
As for the role of nervous system in the nutrition of tissues, protein metabolism of denervated muscle was studied in detail.
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