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1995 Fiscal Year Final Research Report Summary

Physiological role of IGF-I in the nutrition of central nervous system

Research Project

Project/Area Number 06454082
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 食品科学・栄養科学
Research InstitutionThe University of Tokyo

Principal Investigator

NOGUCHI Tadashi  The University of Tokyo, Professor, 農学部, 教授 (50011937)

Project Period (FY) 1994 – 1995
KeywordsIGF-I / IGF-II / IGF-binding protein / Protein nutrition / Insulin-like growth factor
Research Abstract

To elucidate the physiological role of IGF-I in the nutrition of central nervous system, the following studies were performed.
(1) Relate the effect of nutrition of the expressioin of IGF-I,IGF-II and IGF-binding protein genes to the mode of nutrient incorporation by the central nervous.
(2) Elucidate the role of nervous system in the nutrition of tissues.
Gene expression of IGF-I,IGF-II and IGF-binding prteins was studied in various portions of rat brain. IGF-I mRNA was found in various portions of brain but it was scarcely found in cerebrum and not so much in cerebellum and midbrain. On the other hand, IGF-II mRNA was found in every portion of brain. Among IGFBP-1 BP-2 and BP-3, only IGFBP-2 mRNA was found in brain extensively. Dictary protein did not affect the mRNA contents of IGF-I,IGF-II and IGFBP-2 in brain, probably reflecting the conservative nature of brain nutrition. It was suggested that brain nutrition is regulated not by endocrine mode of IGF-I action but by autocrine/paracrine mode of IGF-I action.
As for the role of nervous system in the nutrition of tissues, protein metabolism of denervated muscle was studied in detail.

  • Research Products

    (2 results)

All Other

All Publications (2 results)

  • [Publications] Asako Takenaka 他: "Effect of protein nutrition on insulin-like growth factor-I (IGF-I) receptor in various tissues of rats." J. Nutr. Sci. Vitaminol. submitted.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Asako Takenaka et al.: "Effect of protein nutritioni on insulin-like growth factor-I (IGF-I) receptor in various tissues of rats." J.Nutr, Sci.Vitaminol.(submitted).

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1997-03-04  

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