1995 Fiscal Year Final Research Report Summary
| Project/Area Number |
06454216
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Immunology
|
|---|
| Research Institution | Chiba University School of Medicine |
|---|
Principal Investigator |
TANIGUCHI Masaru Chiba Univ.Sch Med.Professor, 医学部, 教授 (80110310)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KOSEKI Haruhiko Chiba Univ.Sch Med.Instructor, 医学部, 助手 (40225446)
KANNO Masamoto Chiba Univ.Sch Med.Assoc.Professor, 医学部, 助教授 (40161393)
|
|---|
| Project Period (FY) |
1994 – 1995
|
| Keywords | Autoimmune disease / Valpha14 NK T cells / AGM / Invariant Valpha14 / Extrathymic development / SLE / 胸腺外T細胞分化 |
|---|
| Research Abstract |
We identified a novel subset of T cells, NK T cell. The NK T cells contain two distinct subsets : Valpha14NTCR^+ and Valpha14 TCR^-. Valpha14^+ NK T cells are characterized by the expression of an invariant TCRalpha encoded by Valpha14 Jalpha281 with a one-nucleotide N-region in association with Vbeta8.2 TCR.The majority of NK T cells in the periphery are Valpha14^+, while thymic NK T cells are Valpha14^-. Interestingly, only Valpha14^+ NK T cells are tightly correlated with autoimmune disease development. Moreover, Valpha14 NK T cells develop extrathmically before thymus formation at an early stages of embryogenesis, suggesting that Valpha14 NK T cells are distinct lineage from traditional T cells and control the immune system.
|
