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1995 Fiscal Year Final Research Report Summary

Is caner a glucose eater?

Research Project

Project/Area Number 06454372
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionYokohama City University

Principal Investigator

NOGUCHI Yoshikazu  Yokohama City University, School of Medicine Assisitant Professor, 医学部, 講師 (50180724)

Co-Investigator(Kenkyū-buntansha) SATO Shinobu  Yokohama City University, School of Medicine, Assistant Professor, 医学部, 講師 (80244424)
ITO Takaaki  Yokohama City University, School of Medicine, Associate Professor, 医学部, 助教授 (70168392)
Project Period (FY) 1994 – 1995
Keywordsglucose transporters / insulin resistance / glucose clamp
Research Abstract

Cancer cells have been known to have increased rates of glucose metabolism compared with healthy cells. In normal tissue, glucose transporters translocate from the intracytoplasmic domain to the cell membrane to actively transport glucose into cells, however, the function and mechanisms of these transporters in the cancer cells are not clarified yet. This research yielded the following results.
Insulin resistance : More than 80% of the patients with gastrointestinal cancers have insulin resistance of the peripheral tissue. One of the possible mediators of this abnormality may be interleukin (IL) -6, whose serum level is positively correlated with the degree of insulin resistance or M value (glucose metabolised (mg/kg/min) (Submitted). In the cachectic model of Fisher344 rats with methylcholanthrene-induced sarcoma, glucose transporter-4 (Glut-4) in the cytoplasm was significantly decreased quantitatively. Insulin stimulation resulted in smaller amount of the protein to tranlocate to the … More cell membrane. This would be on of the major mechanisms of the insulin resistance in the tumor-bearing state.
Glucose transporters : Of 70 cases of gastric cancer, Glut-1 was expressed in 18.5% of the cases, Glut-2 in 20.9%, Glut-3 in 19.4%, Glut-4 in 40.6% and Glut-5 in 5.5%, respectively. Metastatic foci in the regional lymph nodes were also positive for the transporters expressed in the main tumor. Expression of Glut-1 was positively correlated with the degree of lymphatic vessel and blood vessel invasion by _1=0.402, p<0.001 and _1=0.484, p<0.0001. Glut-4 was more frequently stained in the differentiated history than undifferentiated type. Those characteristics in the glucose metabolism was not related with degree of apoptosis or bc1-2 gene product expression in the main tumor (in preparation for submission).
Summary : In gastric cancer specimens insulin responsive glucose transporter (Glut-4) is very frequently expressed irrespective of the presence of the peripheral insulin resistance of the patients. If both of these were examined preoperatively, we may be able to select a subset of the patients who will be benefited by nutritional support without nourishing the tumor. Less

  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] Tamemoto H: "Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1" Nature. 372. 182-186 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshikawa. T: "Effects of tumor removal and body weight loss on insulin resistance in cancer patients" Surgery. 116. 62-66 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Makino T: "Ultrastructural alterations of hepatocytein the tumor-bearing, cachectic rat" Int J Exp Patho. 75. 433-440 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Noguchi Y: "The effect of prolonged hyperglycemia on metabolic alterations in the subtotally pancreatectomized rat" Surgery Today. 24. 987-993 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Noguchi Y: "Role of insulin resistance in decreasing lipoprotein lipase activity in tymor-bearing rats" Surgery Today. 26. (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Noguchi Y: "Are cytokines possible mediators of cancer cachexia?" Surgery Today. 26. (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tamemoto H: "Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1" Nature. 372. 184-186 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noguchi Y: "The effect of prolonged hyperglycemia on metabolic alterations in subtotally pancreatectomized rate" Surg Today. 24. 987-993 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshikawa T: "Effects of tumor removal and body weight loss on insulin resistance in cacner patients" Surgery. 116. 62-66 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Makino T: "Ultrastructural alterations of hepatocytes in the tumor-bearing cachectic rat" Int J Exp Pathol. 75. 433-440 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noguchi Y: "Cancer and insulin resistance" Geka Chiryou (Surgical treatment). 73. 712-713 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noguchi Y: "Expression of glucose transporters 1 and 4 in human gastric cacer -Preliminary report" J Jpn Surg Ass. 96. 822 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uranaka Y: "Insulin resistance in patients with cardiac disease" Yokohama Igaku. 46. 645-651 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noguchi Y: "Role of insulin resistance in decreasing lipoprotein lipase activity in tumor-bearing rats" Surg Today. (accepted for publication in 1996).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukuzawa K: "Alterations in DNA proliferation in gastric stump mucosa with special reference to topography" Surgery. 118. (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noguchi Y: "Are cytokines possible mediators of cacner cachexia?" Surgery Today. (accepted for publication in 1996).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noguchi Y: "Possible role of TNF alpha and Interleukin-2 in inducing tumor-associated metabolic alterations" Surg Today. (accepted for publication).

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1997-03-04  

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