1996 Fiscal Year Final Research Report Summary
Studies on adjuvant therapies for prevention of hepatic matastasis after resection of pancreatic cancer
| Project/Area Number |
06454378
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
FUKAO Katashi University of Tsukuba, Department of Surgery, Professor, 臨床医学系, 教授 (50091921)
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| Co-Investigator(Kenkyū-buntansha) |
ODA Tatsuya University of Tsukuba, Department of Surgery, Assistant Professor, 臨床医学系, 講師 (20282353)
ISHIKAWA Akio University of Tsukuba, Department of Surgery, Assistant Professor, 臨床医学系, 助教授 (50134226)
OHARA Kiyoshi University of Tsukuba, Department of Radiology, Assistant Professor, 臨床医学系, 助教授 (10034125)
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| Project Period (FY) |
1994 – 1996
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| Keywords | Pancreatic carcinoma / liver metastasis / ostoperative recurrence / preoperative radiation therapy / adjubant therapy / liver function assay test / E-cadherin |
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| Research Abstract |
Postoperative course of the patient with Pancreatic carcinoma is in sufficient, because of the frequent presentation of liver metastasis. Combination of operation and adjuband therapy is only the way for improving the prognosis, however, morbidity and mortality rate may increase. In order to clarify the safes of pancreatico duodenectomy (PD), when radiation therapy is added, and/or the molecular mechanisms of liver metastasis, following issues were analyzed. (1) Because anatomy of eliminatory tract of monkey is similar to those of human, PD for monkey should be a useful model to know and evaluate the in fluence of pre-, intea- and post-operative radiation therapy. We have established the standard PD technique for monkey. (2) We clinically applied liver function assay test, using Trimethadione, for the preoperative patient of PD.(3) Intending to know the molecular mechanisms of liver metastasis, twenty-eight primary pancreatic carcinomas and liver metastatic nodules from 16 or them were analyzed for E-cadherin (E-cad) and alpha-catenin (alpha-cat) protein expression. We found that the status of the E-cad and alpha-cat expression has no significant predictive value, even though there seem to be a higher tendency to liver metastasis for cases with integrity of such cell-cell interaction system.
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