1996 Fiscal Year Final Research Report Summary
Investigation for pathogenesis of syringomyelia with Chiari I malformation and its optimal surgical management.
| Project/Area Number |
06454406
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | University of Hokkaido |
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Principal Investigator |
ABE Hiroshi sch.of Med, University of Hokkaido Professor, 医学部, 教授 (80000983)
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| Co-Investigator(Kenkyū-buntansha) |
HIDA Kazutoshi sch.of Med, University of Hokkaido Assistant Professor, 医学部附属病院, 助手 (10238305)
IWASAKI Yoshinobu sch.of Med, University of Hokkaido Associate Professor, 医学部, 助教授 (00113522)
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| Project Period (FY) |
1994 – 1996
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| Keywords | Syringomyelia / Chiari malformation |
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| Research Abstract |
Syringomyelia has been considered as a rare and difficult disease to treat. Recent development of diagnostic imageing modality and microsurgical technique, however, enabled us to find and surgially treat more numbers of patients in a less-invasive and safe manner.
Ftiology of syringomyelia has been controversial, although several pathogenesis has been proposed. We have performed the clinical reserach regarding with etiology of this disease. We have used the rabbit model received spinal cord injury and demonstrated that posttraumatic arachnoiditis was produced by the disrupted CSF circulation due to adhesive arachnoiditis as well as by the disturbed blood circulation in spinal cord itself. Although we do not have an animal model of syringomyelia associated with Chiari maldormation, we are performing the pathological analysis in the rat model, in which tonsilar herniation was mimiced with the obstruction of foramen magnum and upper cerical spinal cannal with a balloon catheter.
We have surgically treated more than 140 patients with syringomyelia developing novel surgical techniques. Our clinical reserach was mainly focued on the following items : (1) We have quantitatively evaluated the CSF circulatiion of the patients with syringomyelia using with cine-MRI and pre-saturation band. In this study, disturbed CSF circlation at the cranio-vertebral junction profundly related to the pathogenesis of syringomyelia. (2) We have made a modification of our-own-made syrinx-subarachnoid shunt system (Sapporo Shunt) and reduced the risk of the obstruction of the shunt system. (3) We did further investigation about the etiological factors associated with the syringomyelia. In the patients with syringomelia, perioperative problems such as abnormal presentation, birth injuries, or neonatal asphyxia, are revealed ot be significantly more frequent.
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