1995 Fiscal Year Final Research Report Summary
Analysis of genes involving in reactivation of prostate cancer
| Project/Area Number |
06454460
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Yokohama City University |
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Principal Investigator |
KUBOTA Yoshinobu Yokohama City Univ., School of Med, Ass.Professor, 医学部, 助教授 (10106312)
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| Co-Investigator(Kenkyū-buntansha) |
SHUIN Taro Kochi Medical School, Professor, 医学部, 教授 (80179019)
HOSAKA Masahiko Yokohama City Univ., School of Med, Professor, 医学部, 教授 (30106330)
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| Project Period (FY) |
1994 – 1995
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| Keywords | Prostate cancer / Reactivation / gene alterations |
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| Research Abstract |
The molecular background underlying the progression to reactivation stage of prostate cancer is not yet clear.
Alterations of several important genes, such as tumor suppressor genes, oncogenes and steroid receptor genes in reactivated prostate cancers were analyzed in this study.
As results, genes altered in the reactivation of human prostate cancers were found as follows
Androgen Receptor genes・・・・・・・point mutations, gene amplifications
c-myc gene ・・・・・・・・・・・・over expression, gene amplification
P53 gene ・・・・・・・・・・・・point mutations, deletions
RB gene ・・・・・・・・・・point mutations, deletions
bc1-2 gene ・・・・・・・・・・・over expression
Some of these molecular changes have ben suggested to introduce the reactivation of prostate cancer in the process of apoptosis and low androgens status after endocrine therapy.
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Research Products
(11 results)
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[Publications] Dobashi, Y., Shuin, T., Tsuruga, H., Uemura, H., Torigoe, S., Kubota, Y.: "DNA polymerase Beta gene mutation in human prostate cancer" Cancer Res.54. 2827-2829 (1994)
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[Publications] Kubota, Y.Shuin, T., Uemura, H., Fujinami, K., Miyamoto, H., Torigoe, S., Dobashi, Y., Kitamura, H., Iwasaki, Y., Danenberg, K., Danenberg, P.V.: "Tumor suppressor gene P53 mutations in human prostate cancer" Prostate. 27. 18-24 (1995)
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「研究成果報告書概要(欧文)」より
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[Publications] Kubota, Y., Fujinami, K., Uemura, H,Dobashi, Y., Miyamoto, H., Iwasaki, Y., Kitamura, H., Shuin, T.: "Retinoblastoma gene mutations in primary human prostate cancer" Prostate. 27. 314-320 (1995)
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「研究成果報告書概要(欧文)」より
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[Publications] Dobashi, Y., Kubota, Y., Shuin, T., Torigoe, S., Yano, M,Hosaka, M.: "Polymorphisms in the human DNA polymerase beta gene" Human Genetic. 95. 389-390 (1995)
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「研究成果報告書概要(欧文)」より
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