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1996 Fiscal Year Final Research Report Summary

The study on onset of labor and its regulation

Research Project

Project/Area Number 06454469
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

KANAYAMA Naohiro  Department of Obstet & Gyne Hamamatsu University School of Medicine, lecturer, 医学部附属病院, 講師 (70204550)

Co-Investigator(Kenkyū-buntansha) SUMIMOTO Kazuhiro  Hamamatsu University, School of Medicine, assistant, 医学部, 助手 (30126817)
TERAO Toshihiko  Hamamatsu University, School of Medicine, Professor, 医学部, 教授 (60022852)
Project Period (FY) 1994 – 1996
KeywordsInterleukin-8 / Cervical maturation / IL-8 receptors / DHA-S / Collagenase / 早産
Research Abstract

IL-8 induced cervical ripening in non pregnant and pregnant rabbits. After treatment with IL-8 cervices become soft and dilatable. Water content and total glycosaminoglycan were increased, whereas collagen concentration was decreased. Neutrophil influx was observed after exogenous application of IL-8 to the cervices. Collagenase, elastase and gelatinase activities were increased. Similar results, but less marked, were found after treatment of the rabbit cervices with IL-1.
IL-8 receptors (type I and II) were expressed in the chorion and decidua before the initiation of labor, whereas amnion was negatively stained for IL-8 receptors. After initiation of labor pain, IL-8 receptors were strongly stained in amnion, chorion and decidua. IL-8 receptors were also expressed in myometrium.
Stratified squamous epithelium of portio vaginalis was strongly stained for IL-8 receptors (type I and II), whereas the columnar epithelium of the cervical glands was negatively stained for receptors. Cervical fibroblasts and smooth muscle fibers of the cervix were strongly stained for IL-8 receptors. The density of IL-8 receptors was increased after incubation with DHA-S,whereas no effect was found after incubation with E_2, DHA,or progesterone. DHA-S was also found to potentiate the ripening effect of IL-8 on the rabbit cervices.

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Kanayama N: "Urinary trypsin inhibitor : a new drug to treal preterm lcbor, a comparative study with ritodrine" Eur. J. Obstet Gynecol Reprod Biol. 67. 133-138 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kanayama N: "Urinary Trypsin inhibitor suppresses premature cervical ripening" Eur. J. Obstet Gynecol Reprod. Biol. 60. 181-186 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kanayama N: "Urinary Trypsin inhibitor prevents uterine muscle contraction by inhibition of Ca^<++> influx" Am. J. Obstet Gynecol. 173. 192-199 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kanayama N., EL Maradny E., Yamamoto N., Tokunaga N., Maehara K.and TERAO T.: "Urinary trypsin inhibitor : a new drug to treat preterm labor : a comparaive study with ritodrine." Eur.J.Obstet. Gynecol. Reprod. Biol.67. 133-138 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] El Maradny E., Kanayama N., Halim A., Maehara K., Kobayashi T.and Terao T.: "Expression of interleukin-8 receptors in the gestational tissues before and after initiation of labor : Immunohistochemical study." Acta. Obstet. Gynecol. Scand.75. 790-796 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Maehara K., Kanayama N., Halim A., El Maradny E., Uesato T., Fujita M.and Terao T.: "Mechanical stretching induces interleukin-8 gene expression in fetal membranes-A possible role for the initiation of human parturition-Eur" J.Obstet. Gynecol. Reprod. Biol.70. 191-196 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] El Maradny E., Kanayama N., Halim A., Maehara K., Sumimoto K.and Terao T.: "Stretching of fetal membranes increases the concentration of Interleukin-8 and collagenase activity." Am. J.Obstset. Gynecol.174. 843-849 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] El Maradny E., Kanayama N., Halim A., Maehara K., Sumimoto K.and Terao T.: "Biochemical changes in the cervical tissue of rabbit induced by interleukin-8, interleukin-1beta, dehydroepiandrosterone sulfate and prostaglandin E_2 : a comparative study." Human. Reprod.11. 1099-1104 (1966)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] El Maradny E., Kanayama N., Halim A., Maehara K., Kobayashi T.and Terao T.: "Effects of urinary trypsin inhibitor on myometrial contraction in term and preterm deliveries." Gynecol. Obstet. Invest.41. 96-102 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] El Maradny E., Kanayama N., Maehara K., Kobayashi T.and Terao T.: "Dehydroepiandrosterone sulfate potentiates the effect of interleukin-8 on the cervix." Gynecol. Obstet. Invest.42. 191-195 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] El Maradny E., Kanayama N., Halim A., Maehara K., Kobayashi T.and Terao T.: "Biochemical changes in the cervical mucus after application of laminaria tent." Acta. Obstet. Gynecol. Scand.75. 203-207 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kanayama N., El Maradny E., Halim A., Maehara K., Kajuwara Y.and Terao T.: "Urinary trypsin inhibitor suppresses premature cervical ripening." Eur. J.Obstet. Gynecol. Reprod. Bilo.60. 181-186 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kanayama N., El Maradny E., Halim A., Liping S., Maehara K., Kajuwara Y.and Terao T.: "Urinary trypsin inhibitor prevents uterine muscle contraction by inhibition of Ca^<2+>influx." Am. J.Obstet. Gynecol.173. 192-199 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Maehara K., Kanayama N., Halim A., El Maradny E., Oda T., Fujita M.and Terao T.: "Downregulation of interleukin-8 gene expression in HL60 cell line by human Kunitz-type trypsin inhibitor." Biochem. Biophys. Res. Commun.206. 927-934 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kanayama N., Halim A., Maehara K., Kajuwara Y., Fujie M.and Terao T.: "Kunitz-type trypsin inhibitor prevents LPS-induced increase of cytosolic free Ca^<2+> in human neutrophils and HUVEC cells." Biochem. Biophys. Res. Commun.207. 324-330 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kanayama N., Kajiwara Y., Goto J., El Maradny E., Maehara K., Andou K.and Terao T.: "Inactivation of interleukin-8 by aminopeptidase N (CD 13)." J.Leuko. Biol.57. 129-134 (1995)

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      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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