1995 Fiscal Year Final Research Report Summary
Development of Bioabsorbable membrane with guided tissue regenevatlar
| Project/Area Number |
06454545
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Conservative dentistry
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| Research Institution | TOKYO DENTAL COLLEGE |
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Principal Investigator |
YAMADA Satoru Tokyo Dental College, Professor, 歯学部, 教授 (20103351)
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| Co-Investigator(Kenkyū-buntansha) |
HIDAKA Takayuki Tokyo Dental College, Lecture, 歯学部, 講師 (40175550)
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| Project Period (FY) |
1994 – 1995
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| Keywords | Absorbable membrane, / Clinical study, / Guided tissue regeneration / Six months / Histopathological examination |
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| Research Abstract |
This investigation assessed the clinical efficacy of absorbable membrane (Poly [lactic acid-co-glycolic acid]) on the guided tissue regeneration technique (GTR). A total of 60 patients with mainly advanced adult periodontitis, including lesions with angular bony defects, 2-wall, 3-well and compound infrabony defects and class I,class II and class III furcation defects, were studied. The group included 22 males and 38 females ; ages ran-ged from 24 to 68 years with a mean age of 48 years. Following completion of the hygienic phase of treatment, clinical measurements including probing depth and clinical attachment level were recorded. Bone defects were surgically exposed. Defects were treated with open flap debridement plus absorbable periodontal membrane. Six months postsurgery, clinical data were rerecorded. Postsurgical healing was uneventful. Inflammation of the soft tissue covering the device or othere adverse events related to this absorbable membrance have not seen in any patients. Mean probing depth was reduced from 5.7mm to 2.9mm, with a mean probing depth reduction of 2.8mm (P<0.001). Relative attachment level was improved from an average of 9.0mm to 6.8mm, with a mean gain of probing attachment of 2.2mm (P<0.001). There was minimal gingival recession, averaging 0.6mm.
These results suggest that the absorbable membranes (Poly [lactic acid-co-glycoric acid]) used in the GTR procedure are valuable in the treatment of adult periodontitis.
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