1995 Fiscal Year Final Research Report Summary
Development of Antibacterial and Deodorant Denture
| Project/Area Number |
06454554
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
補綴理工系歯学
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| Research Institution | Osaka University |
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Principal Investigator |
TERAOKA Fumio Osaka Univ.Fac.of Dent.Assist., 歯学部, 助手 (00099805)
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| Co-Investigator(Kenkyū-buntansha) |
ONO Takahiro Osaka Univ.Fac.of Dent.Assoc.Prof., 歯学部・附属病院, 講師 (30204241)
SOUMURA Taiji Osaka Univ.Fac.of Dent.Assoc.Prof., 歯学部, 講師 (10154692)
OKAZAKI Masayuki Osaka Univ.Fac.of Dent.Assoc.Prof., 歯学部, 助教授 (30107073)
TAKAHASHI Junzo Osaka Univ.Fac.of Dent.Prof., 歯学部, 教授 (80029149)
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| Project Period (FY) |
1994 – 1995
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| Keywords | Bamboo extract / Candida albicans / antibacterial activity / MIC / Tissue conditioner / Base resin |
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| Research Abstract |
This study investigated bamboo extract, which was distillled at 200ﾟC under a reduced pressure of 20 mm Hg, as an autibacterial agent or disinfectant for dental use. Antibacterial and bactericidal activities of the bamboo extract against Staphylococcus aureus (S.aureus), Streptococcus mutans (S.mutans) and Candida albicans (C.albicans) were examined by measuring MIC (minimum inhibitory concentration) and MBC (minimum bactericidal concentration), respectively. The MIC of the bamboo extract was 2.5% against C.albicans. The bactericidal activity was confirmed by MBC,which was nearly equal to the MIC,against these microorganism. The 5% bamboo extract exhibited a marked antibacterial and bactericidal activity against these microorganiam. The bamboo extract contained more than 40 components, which were mainly Furans or Phenols. All of the mice were in normal health before and after the toxicity tests. These results suggest that the bamboo extract can be used safely as an antibacterial agent or disinfectant comparable to conventional compounds used for those purpose.
Antibacterial activity of tissue conditioners and dentures containing bamboo extract on Candida albicans was investigated. Then the effects of bamboo extract on the attachment of Candida albicans on tissue conditioners and dentures were studied in vitro and in vivo. When tissue conditioners containing bamboo extract were immersed in Heart infusion (HI) agar medium, the bamboo extract scacely eluted. The adhesion of Candida albicans on tissue conditioners containing 10 wt% bamboo extract was significantly inhibited.
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