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1995 Fiscal Year Final Research Report Summary

Diversity of FGF receptor and their physiological significance

Research Project

Project/Area Number 06454598
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

ITOH Nobuyuki  Kyoto University, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (10110610)

Co-Investigator(Kenkyū-buntansha) OZAKI Keiichi  Kyoto University, Faculty of Pharmaceutical Sciences, Assistant Professor, 薬学部, 助手 (50252466)
Project Period (FY) 1994 – 1995
KeywordsFGF / brain / receptor / growth factor / gene
Research Abstract

The fibroblast growth factor (FGF) receptor family consists of four members, FGFR-1, FGFR-2, FGFR-3 and FGFR-4, that are closely related receptor tyrosine kinases. We examined the expression of mRNAs for four members of rat FGF receptor family in the brain. The FGFR-1, FGFR-2, FGFR-3 mRNAs were widely but differentially expressed in the brain. However, the FGFR-4 mRNA was preferentially expressed in very small discrete regions in the epithalamus. The FGFR-1 mRNA was strongly expressed in several regions including the hippocampus, cerebellum and pedunculopotine tegmental nucleus. The FGFR-2 mRNA expression was high in the choroid plexus, and moderate in the fiber-rich regions (the corpus callosum, external capsule and internal capsule). The FGFR-3 mRNA was diffusely expressed in the brain. In contrast, the FGFR-4 was preferentially expressed in the medial habenular nucleus. We also examined cellular localization of these mRNAs in the brain. Although the FGFR-1 mRNA was preferentially expressed in neurons, the FGFR-2 and FGFR-3 mRNAs were preferentially expressed in oligodendrocytes and astrocytes, respectively. The FGFR-4 mRNA was preferentially in cholinergic neurons. These findings that indicate that these receptors have different roles in the brain.

  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] Miyake ら: "Transient expression of FGF receptor-4mRNA in the rat cerebellum during postnatal development" Mol. Brain Res.31. 95-100 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miyake ら: "Rat fibroblast growth factor-4mRNA in the brain is preferentially expressed in cholinergic neurons in the medial habenular nucleus" Neurosci. Lett.203. 101-104 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miyake ら: "Rat oligodendrocytes and astrocytes preferentially express fibroblast growth factor receptor-2 and -3 mRNAs" J. Neurosci. Res.(in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miyake A., Minami M., Satoh M., Ohta M., Itoh N.: "Transient expression of FGF receptor-4 mRNA in the rat cerebellum during postnatal development" Mol.Brain Res.31. 95-100 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miyake A., Itoh N.: "Rat fibroblast growth factor-4 mRNA in the brain is preferentially expressed in cholinergic neurons in the medial habenular nucleus" Neurosci.Lett.203. 101-104 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miyake A., Hattori Y., Ohta M., Itoh N.: "Rat oligodendrocytes and astrocytes preferentially express fibroblast growth factor receptor-2 and -3 mRNAs" J.Neurosci. Res. (in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1997-03-04  

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