1995 Fiscal Year Annual Research Report

侵襲・非侵襲法による霊長類(サル・ヒト)の情動・記憶の大脳辺縁系機構

Research Project

Project/Area Number	06454706
Research Institution	TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
Principal Investigator	小野武年富山医科薬科大学, 医学部, 教授 (50019577)
Co-Investigator(Kenkyū-buntansha)	田淵英一富山医科薬科大学, 医学部, 助手 (70272911) 田村了以富山医科薬科大学, 医学部, 助手 (60227296) 西条寿夫富山医科薬科大学, 医学部, 助教授 (00189284)
Keywords	大脳辺縁系 / 記憶 / 情動 / 痴呆 / ニューロン活動 / 双極子追跡法 / MRI / 認知
Research Abstract	1)侵襲法(神経生理学的研究) サル中隔核(SP)から単一ニューロン活動を記録し,サルの居場所の違いにより呈示物体の意味が変化する条件課題(PGN課題)および呈示物体の意味が常に一定である非条件課題(AGN/SGN課題)に対する応答様式を解析した。その結果,サルSPより430個のニューロン活動を記録し,そのうち190個が何らかの応答を示した。I.これら応答ニューロンの30.5%はサルの居場所に関して識別的に応答した。II.条件(PGN)および非条件(AGN)課題の両課題をテストできたSPニューロンのうち,59.7%はPGN課題に対してだけ,その意味(Go-報酬/Nogo-無報酬)に応じて識別的に応答した。このような条件課題特異的ニューロンは,本研究により初めて見出され,SPが条件性・場所-物体識別課題の遂行に重要な役割を果していることを強く示唆する。III.PGNおよびAGN課題に非識別的に応答したニューロンに対してさらにSGN課題をテストし,ほとんど(90.5%)は物体の報酬性(報酬/無報酬)に対して識別的に応答した。これらニューロンの応答性は,消去学習により物体の報酬性を直接変化させるとそれに応じて変化することからも確認された。以上からSPは,居場所の認知→居場所の違いにより変化する物体の意味の識別という一連の過程を統合する上で重要な役割を果たしていることが示唆される。 2)非侵襲法(双極子追跡法,機能的MRI法) i)パターンオンセット刺激による視覚誘発電位(VEP)の電流発生源(双極子)を双極子追跡(DT)法により推定した。等価双極子は,視野の中心部刺激では,刺激野反対側の後頭葉視覚領の後方に,視野の周辺部刺激では,刺激野反対側の後頭葉視覚領の前方に推定され,非侵襲的にヒトの後頭葉視覚領における網膜部位局在性をほぼ再現することができた。また,顔写真に対するVEPを解析することにより,潜時約150msecで後頭葉-側頭葉移行部に双極子が両側性に存在することが明らかになった。ii)昨年度に開発した特殊脳定位固定装置を用い,リック(舐め)行動中のラットの頭部をIMRIで撮影した。グルコース溶液および蒸留水のリック行動中の信号強度を差分した結果,グルコース溶液摂取により視床下部の信号強度が増加(血流が増加)することが明らかになった。

Research Products

(34 results)

All Other

All Publications (34 results)

[Publications] Tagoh,H.: "Reciprocal lL-lβ gene expression in medial and lateral hypothalamic areas in SART-stressed mice." Neurosci. Let.184. 17-20 (1995)
[Publications] Tabuchi,E.: "Ischemic neuronal damage specific to monkey hippocampus: histological investigation." Brain Res. Bull.37. 73-87 (1995)
[Publications] Nishijo,H.: "Physiological results of monkey brain ischemia,and protection by a calcium entry blocker." Brain Res. Bull.37. 89-101 (1995)
[Publications] Kita,T.: "Place and contingency differential responses of monkey septal neurons during conditional place-object discrimination." J. Neurosci.15. 1683-1703 (1995)
[Publications] Eifuku,S.: "Neuronal activity in the primate hippocampal formation during a conditional association task based on the subject's location." J. Neurosci.15. 4952-4969 (1995)
[Publications] Uwano,T.: "Neuronal responsiveness to various sensory stimuli, and associative learning in the rat amygdala." Neurosience. 68. 339-361 (1995)
[Publications] Hayashi,N.: "Generrators of somatosensory evoked potentials investigated by dipole tracing in the monkey." Neuroscinece. 68. 323-338 (1995)
[Publications] Hayashi,N.: "Functional image-guided neurosurgical simulation system using computerized three-dimensional graphics and dipole tracing." Neurosurgery. 37. 695-703 (1995)
[Publications] Masuda,R.: "Neuronal responses in monkey basal forebrain regions during visual discrimination task." Neurobiology of Learning and Memory. (in press.).
[Publications] Ono,T.: "Amygdala rolc in conditioned associative learning." Prog. Neurobiol.46. 401-422 (1995)
[Publications] Kondoh,T.: "Increased histidine preference during specific alteration of rhythm of environmental tempcrature stress in rats." Behav. Neurosci.(in press.)
[Publications] 福田正治: "海馬体ニューロンと場所学習・記憶." 日本生理学雑誌. 57. 145-154 (1995)
[Publications] 小野武年: "側頭葉の構造と情動・記憶機能." 脳と精神の医学. 6. 131-143 (1995)
[Publications] 小野武年: "脳と栄養調節." 日本外科学会雑誌. 7. 423-429 (1995)
[Publications] 西条寿夫: "海馬体の構造と機能.第2部大脳皮質の構造と機能." 蛋白質,核酸,酵素.40. 814-828 (1995)
[Publications] 田村了以: "大脳辺縁系と陳述記憶.脳と記憶." BRAIN MEDICAL. 7. 63-72 (1995)
[Publications] 西条寿夫: "感情と情動をめぐる学説-情動を司る脳-" CLINICAL NEUROSCIENCE. 13. 1025-1029 (1995)
[Publications] 小野武年: "感情と情動の生理学-情動発現、表出の脳内機構-" CLINICAL NEUROSICIENCE. 13. 1035-1039 (1995)
[Publications] Hayashi,N.: "Generators of somatosensory evoked potentials investigated by dipole tracing in the monkey." Neuroscinece. 68. 323-338 (1995)
[Publications] Hayashi,N.: "Functional image-guided neurosurgical simulation system using computerized three-dimensional graphics and dipole tracing." Neurosurgery. 37. 695-703 (1995)
[Publications] 西条寿夫: "海馬体の構造と機能.第2部大脳皮質の構造と機能." 蛋白質,核酸,酵素.40. 814-828 (1995)
[Publications] 西条寿夫: "感情と情動をめぐる学説-情動を司る脳-" CLINICAL NEUROSCIENCE. 13. 1025-1029 (1995)
[Publications] 小野武年: "感情と情動の生理学-情動発現、表出の脳内機構-" CLINICAL NEUROSICIENCE. 13. 1035-1039 (1995)
[Publications] Nishijo,H.: "Involvement of amygdala and scpto-hippocampus in emotion, In Emotion, Memory and Bchavtor-Studies on Human and Nonhuman Primatcs" Nakajima,T. and Ono,T. (Eds.),Japan Scientific Soc. Press: Tokyo,17-30 (1995)
[Publications] Ono,T.: "Place-correlates of monkey hippocampal ncuronal activity and its significance in memory" Nakajima,T. and Ono,T. (Eds.), Japan Scientific Soc.Press: Tokyo, 139-152 (1995)
[Publications] Nishijo,H.: "Hippocampal neuronal responsiveness to complex and simple conditional association tasks in monkeys. In: The Hippocampus: Functions and Clinical Relevance" Kato,N. (Ed.). Elsevier: New York(in press.), (1996)
[Publications] Nishijo,H.: "Monkey hippocampal neuron responses during spatial moving and place-dependent conditional task. In: Perception, Memory and Emotion: Frontier in Neuroscience" Ono,T., McNaughton, B. L., Molotchnikoff, S., Rolls, E. T., and Nishijo,H. (Eds.).Elsevier(in press.), (1996)
[Publications] Tamura,R.: "Responsiveness of monkey septal neurons during object discrimination based on place recognition. In: The Hippocampus: Functions and Clinical Relevance" Kato,N. (Ed.). Elsevier: New York(in press.), (1996)
[Publications] 小野武年: "認知機能の分子生物学.分子神経科学の最先端" 岡田善雄監修,遠山正彌,塩坂貞夫編,厚生社,大阪, 95-115 (1995)
[Publications] 小野武年: "情動・記憶に関連する神経細胞: 第1章情動と学習・記憶の基礎" 「脳・心・コンピュータ,日本物理学会編,丸善, 46-74 (1996)
[Publications] Nishijo,H.: "Monkey hippocampal neuron responses during spatial moving and place-dependent conditional task. In: Perception, Memory and Emotion: Frontier in Neuroscience" Ono,T., McNaughton, B. L., Molotchnikoff, S., Rolls, E.T., and Nishijo,H. (Eds.). Elsevier(in press), (1996)
[Publications] Nishijo,H.: "Hippocampal neuronal responsiveness to complex and simple conditional association tasks in monkeys. In: The Hippocampus: Functions and Clinical Relevance" Kato,N. (Ed.).Elsevier: New York(in press.), (1996)
[Publications] Tamura,R.: "Responsiveness of monkey septal neurons during object discrimination based on place recognition. In: The Hippocampus: Functions and Clinical Relevance" Kato,N. (Ed.). Elsevier: New York(in press), (1996)
[Publications] 小野武年: "認知機能の分子生物学.分子神経科学の最先端" 岡田善雄監修,遠山正彌,塩坂貞夫編,厚生社,大阪, 95-115 (1995)

1995 Fiscal Year Annual Research Report

侵襲・非侵襲法による霊長類(サル・ヒト)の情動・記憶の大脳辺縁系機構

Principal Investigator

小野 武年 富山医科薬科大学, 医学部, 教授 (50019577)

Research Products

[Publications] Tagoh,H.: "Reciprocal lL-lβ gene expression in medial and lateral hypothalamic areas in SART-stressed mice." Neurosci. Let.184. 17-20 (1995)

[Publications] Tabuchi,E.: "Ischemic neuronal damage specific to monkey hippocampus: histological investigation." Brain Res. Bull.37. 73-87 (1995)

[Publications] Nishijo,H.: "Physiological results of monkey brain ischemia,and protection by a calcium entry blocker." Brain Res. Bull.37. 89-101 (1995)

[Publications] Kita,T.: "Place and contingency differential responses of monkey septal neurons during conditional place-object discrimination." J. Neurosci.15. 1683-1703 (1995)

[Publications] Eifuku,S.: "Neuronal activity in the primate hippocampal formation during a conditional association task based on the subject's location." J. Neurosci.15. 4952-4969 (1995)

[Publications] Uwano,T.: "Neuronal responsiveness to various sensory stimuli, and associative learning in the rat amygdala." Neurosience. 68. 339-361 (1995)

[Publications] Hayashi,N.: "Generrators of somatosensory evoked potentials investigated by dipole tracing in the monkey." Neuroscinece. 68. 323-338 (1995)

[Publications] Hayashi,N.: "Functional image-guided neurosurgical simulation system using computerized three-dimensional graphics and dipole tracing." Neurosurgery. 37. 695-703 (1995)

[Publications] Masuda,R.: "Neuronal responses in monkey basal forebrain regions during visual discrimination task." Neurobiology of Learning and Memory. (in press.).

[Publications] Ono,T.: "Amygdala rolc in conditioned associative learning." Prog. Neurobiol.46. 401-422 (1995)

[Publications] Kondoh,T.: "Increased histidine preference during specific alteration of rhythm of environmental tempcrature stress in rats." Behav. Neurosci.(in press.)

[Publications] 福田正治: "海馬体ニューロンと場所学習・記憶." 日本生理学雑誌. 57. 145-154 (1995)

[Publications] 小野武年: "側頭葉の構造と情動・記憶機能." 脳と精神の医学. 6. 131-143 (1995)

[Publications] 小野武年: "脳と栄養調節." 日本外科学会雑誌. 7. 423-429 (1995)

[Publications] 西条寿夫: "海馬体の構造と機能.第2部大脳皮質の構造と機能." 蛋白質,核酸,酵素.40. 814-828 (1995)

[Publications] 田村了以: "大脳辺縁系と陳述記憶.脳と記憶." BRAIN MEDICAL. 7. 63-72 (1995)

[Publications] 西条寿夫: "感情と情動をめぐる学説-情動を司る脳-" CLINICAL NEUROSCIENCE. 13. 1025-1029 (1995)

[Publications] 小野武年: "感情と情動の生理学-情動発現、表出の脳内機構-" CLINICAL NEUROSICIENCE. 13. 1035-1039 (1995)

[Publications] Hayashi,N.: "Generators of somatosensory evoked potentials investigated by dipole tracing in the monkey." Neuroscinece. 68. 323-338 (1995)

[Publications] Hayashi,N.: "Functional image-guided neurosurgical simulation system using computerized three-dimensional graphics and dipole tracing." Neurosurgery. 37. 695-703 (1995)

[Publications] 西条寿夫: "海馬体の構造と機能.第2部大脳皮質の構造と機能." 蛋白質,核酸,酵素.40. 814-828 (1995)

[Publications] 西条寿夫: "感情と情動をめぐる学説-情動を司る脳-" CLINICAL NEUROSCIENCE. 13. 1025-1029 (1995)

[Publications] 小野武年: "感情と情動の生理学-情動発現、表出の脳内機構-" CLINICAL NEUROSICIENCE. 13. 1035-1039 (1995)

[Publications] Nishijo,H.: "Involvement of amygdala and scpto-hippocampus in emotion, In Emotion, Memory and Bchavtor-Studies on Human and Nonhuman Primatcs" Nakajima,T. and Ono,T. (Eds.),Japan Scientific Soc. Press: Tokyo,17-30 (1995)

[Publications] Ono,T.: "Place-correlates of monkey hippocampal ncuronal activity and its significance in memory" Nakajima,T. and Ono,T. (Eds.), Japan Scientific Soc.Press: Tokyo, 139-152 (1995)

[Publications] Nishijo,H.: "Hippocampal neuronal responsiveness to complex and simple conditional association tasks in monkeys. In: The Hippocampus: Functions and Clinical Relevance" Kato,N. (Ed.). Elsevier: New York(in press.), (1996)

[Publications] Nishijo,H.: "Monkey hippocampal neuron responses during spatial moving and place-dependent conditional task. In: Perception, Memory and Emotion: Frontier in Neuroscience" Ono,T., McNaughton, B. L., Molotchnikoff, S., Rolls, E. T., and Nishijo,H. (Eds.).Elsevier(in press.), (1996)

[Publications] Tamura,R.: "Responsiveness of monkey septal neurons during object discrimination based on place recognition. In: The Hippocampus: Functions and Clinical Relevance" Kato,N. (Ed.). Elsevier: New York(in press.), (1996)

[Publications] 小野武年: "認知機能の分子生物学.分子神経科学の最先端" 岡田善雄監修,遠山正彌,塩坂貞夫編,厚生社,大阪, 95-115 (1995)

[Publications] 小野武年: "情動・記憶に関連する神経細胞: 第1章情動と学習・記憶の基礎" 「脳・心・コンピュータ,日本物理学会編,丸善, 46-74 (1996)

[Publications] Nishijo,H.: "Monkey hippocampal neuron responses during spatial moving and place-dependent conditional task. In: Perception, Memory and Emotion: Frontier in Neuroscience" Ono,T., McNaughton, B. L., Molotchnikoff, S., Rolls, E.T., and Nishijo,H. (Eds.). Elsevier(in press), (1996)

[Publications] Nishijo,H.: "Hippocampal neuronal responsiveness to complex and simple conditional association tasks in monkeys. In: The Hippocampus: Functions and Clinical Relevance" Kato,N. (Ed.).Elsevier: New York(in press.), (1996)

[Publications] Tamura,R.: "Responsiveness of monkey septal neurons during object discrimination based on place recognition. In: The Hippocampus: Functions and Clinical Relevance" Kato,N. (Ed.). Elsevier: New York(in press), (1996)

[Publications] 小野武年: "認知機能の分子生物学.分子神経科学の最先端" 岡田善雄監修,遠山正彌,塩坂貞夫編,厚生社,大阪, 95-115 (1995)

小野武年富山医科薬科大学, 医学部, 教授 (50019577)