| Project/Area Number |
06454719
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
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| Research Institution | Cancer Institute |
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Principal Investigator |
HINO Okio Cancer Institute, Department of Experimental Pathology, Chief, 実験病理部, 部長 (90127910)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Toshiyuki Cancer Institute, Department of Experimental Pathology, Associate, 実験病理部, 研究員 (40260070)
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| Project Period (FY) |
1994 – 1995
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| Keywords | Hereditary cancer / Animal model / Renalcarcinogenesis / TSC2 gene / Tuberous sclerosis / Tumor suppressor gene |
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| Research Abstract |
The Eker rat model of hereditary renal carcinoma, originally reported by R.Eker in 1954, is an example of Mendelian dominantly inherited predisposition to a specific cancer in an experimental animal. Finally, we identified a germline retrotransposon insertion in the rat homologue of the human tuberous sclerosis (TSC2) gene, 40 years after the discovery of the Eker rat in Oslo.
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