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1996 Fiscal Year Final Research Report Summary

DEVELOPMENT OF AN ARTIFICIAL PLACENTA

Research Project

Project/Area Number 06557066
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section試験
Research Field Embryonic/Neonatal medicine
Research InstitutionJUNTENDO UNIVERSITY,SCHOOL OF MEDICINE

Principal Investigator

KUWABARA Yoshinori  Juntendo Univ.School of Medicine, Professor, 医学部, 教授 (20010324)

Co-Investigator(Kenkyū-buntansha) KUWANA Katsuyuki  Senko Ika Kogyo Co.Dpt.Develop.of New Technology, Assistant Manager, 開発部, 課長代理
NAKAMURA Yasushi  Juntendo Univ.School of Medicine, Assistant, 医学部, 助手 (70207926)
YOSHIDA Koyo  Juntendo Univ.School of Medicine, Assistant Prof., 医学部, 講師 (90166950)
Project Period (FY) 1994 – 1996
Keywordsartificial placenta / extrauterine fetal incubation / experimental perinatology / extracorporeal circulation / extracorporeal membrane oxygenator
Research Abstract

The aim of our study was to newly develop an extrauterine incubation system closely resembled that of a fetus in utero in both the extracorporeal and intracorporeal environments, in order to incubate and extremely premature baby or a fetus having a disease which should be treated in utero. The extrauterine incubation system consisted of an artificial womb containing artificial amniotic fluid and a cpmplete artificial placental system with a membrane oxygenator which was used for A-V ECMO.Materials we used were goat fetuses. After long-term extrauterine incubation, goat fetuses were tried to remove from the incubator and stimulated to initiate lung respiration. At the first, we examined the feasibility of long-term extrauterine incubation of relatively matured (125-130 days of gestation) goat fetuses, and at the second, premature (90-100 days of gestation) goat fetuses. In premature goat fetuses as well as relatively matured ones, long-term extrauterine incubation without cardiac failure could be achieved by administration of diazepam and pancronium bromide into the blood circuit to supress fetal movement an swallowing. Because they could be implicated in fetal deterioration during extrauterine fetal incubation. After removal from the incubator, these animals could survive for more than 1 week, if only with ventilator support. In consequence, we could prove that long-term umbilical A-V ECMO was in itself not harmful to fetal survival. But the administered pancronium bromide might have caused fetal neuromuscular disturbances that could prevent spontaneous breathing. Before this system can be applied for humans, numerous problems such as water homeostasis and nutrition maintenance as well as the muscle weakness due to long term immobilization must be resolved.

  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] Shigeru Itoh, Koyo Yoshida, Yasushi Nakamura, Naoki Mitsuhashi, Yoshinori Kuwabara: "Cardiovascular Responses of Goat Fetuses to Hypercapnia during Extrauterine Incubation Using Extracorporeal Membrane Oxygenation." J.Obstet.Gynecol.Res.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kuwabara Yoshinori, Koyo Yoshida, Yasushi Nakamura, Shigeru Itoh: "Extrauterine Incubation of Isolated Goat Fetuses by Using Artificial Placenta." J.Repro.Develop.41 (5). j55-j60 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nobuya Unnno, Yoshinori Kuwabara, et al: "Development of an Artificial Olacenta : Endocrine Responses of Goat Fetuses during Long-Term Extrauterine Incubation with Umbilical Arteriovenous Extracorporeal Membrane Oxygenation." Endocrine Journal. 41 (Suppl). S69-S76 (1994)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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