1995 Fiscal Year Final Research Report Summary
Development of artificial synapse with micro-fablicated structures
| Project/Area Number |
06557067
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| Research Category |
Grant-in-Aid for Developmental Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
CHINZEI Tsuneo The University of Tokyo, Faculty of Medicine, Instructor, 医学部, 助手 (20197643)
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| Co-Investigator(Kenkyū-buntansha) |
FUKATSU Susumu The University of Tokyo, College of Arts and Sciences, Associate Professor, 教養学部, 助教授 (60199164)
ABE Yusuke The University of Tokyo, Faculty of Medicine, Instructor, 医学部, 助手 (90193010)
FUJIMASA Iwao The University of Tokyo, Research Center for Advanced Science and Technology, Pr, 先端科学技術研究センター, 教授 (30010028)
IMACHI Kou The University of Tokyo, Faculty of Medicine, Professor, 医学部, 教授 (10010076)
MABUCHI Kunihiko The University of Tokyo, Research Center for Advanced Science and Technology, As, 先端科学技術研究センター, 助教授 (50192349)
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| Project Period (FY) |
1994 – 1995
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| Keywords | reconstructive electrode / polymide / spinal evoking potential / spinal root / spinal endoscopy |
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| Research Abstract |
In this study, nerver-reconstructive electrode and approach method to spinal root with endoscope were developed to realize the electrical interface for peripheral nerve.
Nerver-reconstructive electrodes on polyimide base with multi-channel access were newly designed, and were proved with animal experiment. Both sides of electrode made bye copper film pattern, 35 micro-meter thickness, was laminated with polymide film, 50 micro-meter thickness. Through holes were penetrated with excimer laser, and were coated with platinum sputtering. Ischiatic nerve of six rats were cut down and were implanted these electrodes. Sacrificed after 2 weeek, the nerve were reconstructed through the electrode hole histologically, but evoked potential was not detected yet.
The endoscopic identification method of relation between dorsal root and peripheral nerve was developed. A small diameter catheter with multiple electrode, 0.5 cm interval on longitudinal axis, was inserted in epidural space of goats. Spinal evoked potential was measured with this catheter on every pair of electrode. The amplitude and phase of potential indicated the nearest electrode to stimulated root. The color marking of catheter of the electrode was searched with endoscope. In this way, the stimulated root was identified with endoscope. The evoked potential of radicles of the root was investigated with the thin bipolar electrode through working channel of endoscope. On two or three radicles among the root, evoked potential was detected. This result means that the electrode on radicles can realize the selective interaction to the peripheral nerve system.
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