| Project/Area Number |
06557075
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 試験 |
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| Research Field |
Thoracic surgery
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| Research Institution | Research institution of National Cardiovascular Center |
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Principal Investigator |
MATSUDA Takehisa National Cardiovascular Center-Department of Bioengineering, Head, 生体工学部, 部長 (60142189)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAICHI Shigeko National Cardiovascular Center-Department of Structural Analysis, Senior Staff, 病因部, 室長 (00093930)
SUGAWARA Takashi National Cardiovascular Center-Department of Artificial Organs, Staff, 人工臓器部, 研究員 (70235860)
NAKAYAMA Yasuhide National Cardiovascular Center-Department of Bioengineering, Staff, 生体工学部, 研究員 (50250262)
TAKIMIZAWA Keiichi National Cardiovascular Center-Department of Bioengineering, Staff, 生体工学部, 研究員 (10163312)
SEKI Junji National Cardiovascular Center-Department of Bioengineering, Senior Staff, 生体工学部, 室長 (20163082)
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| Project Period (FY) |
1994 – 1996
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| Keywords | Artificial Graft / Neoarterial Regeneration / Scaffold / Matrix / Cytokine |
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| Research Abstract |
The development of small caliber artificial grafts has been long awaited in cardiovascular surgey. Minimal thrombus formation in an early implantation and rapid neoarterial regeneration and well-controlled morphogenesis in the following period are essential for vital replacement with diseased vessels. To this esd, we have taken multi-faceted approaches including scaffold design with excimer laser-directed controlled microporosity to provide compliance matching as well as transmural tissue ingrowth, metrix design and cytokine immobilization, both of which are designed to enhance endothelialization and neoarterial regeneration, and cellular engineering providing a hybrid tubular tissue with three-layred hierarchical structure biomimicking to the layring of natural vessels. Onece these disciplines were fully formulated into a design graft, such grafts undergo to remoldel themselves in vivo, producing a vascular tissues resembling that of natural vessel in terms of structure and function.
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