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1996 Fiscal Year Final Research Report Summary

Development of a new strategy of hyperthermia for metastatic bone tumor

Research Project

Project/Area Number 06557083
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section試験
Research Field Orthopaedic surgery
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

TSUBOYAMA Tadao  Kyoto University Lecturer Faculty of Medicine, 医学研究科, 講師 (90261221)

Co-Investigator(Kenkyū-buntansha) AKAGI Masao  Kyoto University, Instructor Faculty of Medicine, 医学研究科, 助手 (00273441)
HIRAOKA Masahiro  Kyoto University Profussor Faculty of Medicine, 医学研究科, 教授 (70173218)
Project Period (FY) 1994 – 1996
Keywordsexperimental bone tumor / hyperthermia / intramedullary nail / anti-tumor effects
Research Abstract

A new localized hyperthermia system for an experimental bone tumor in the rabbit tibia was developed. This system was composed of an induction coil, generator and a Kirschner wire, which was inserted into the medullary canal of the tibia as a heat-generating ferromagnetic implant. The metastatic bone tumor model was created by implantation of VX2 carcinoma in the medullary canal of the tibia diaphysis. Ten days after VX2 implantation, hyperthermia was induced for 50 min. Three weeks after the treatment, rabbits were sacrificed for histological and radiological evaluation. According to the semi-quantitative scoring system, anti-tumor effects of the single dose of hyperthermia was noted radiologically (<0.01) and histologically (<0.05) where the temperature was at a sufficient level to cause hyperthermia (>42.5゚C). This new heating method, which is relatively simple and clinically applicable, appears to be promising for the treatment of metastatic tumors of the long bone. The intramedullary nail of the alloy with low Curie point might make our hyperthermia system much safer and simpler for clinical use than that of stainless steel.

  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Ikenaga, M. et al.: "Localized hyperthermic treatment of experimental bone tumors with ferromagnetic ceramics." Journal of Orthopaedic Research.11. 849-855 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M. Ikenaga et al.: "Hyperthermic treatment of canine tibia through RF inductive heating of an intramedullary nail : anew experimeutal approach to hyperthermia for metastatic bone fumors" Int. J. Hyperthermia. 10. 507-516 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 赤木将男 他: "実験的転移性骨腫瘍に対する髄内釘を用いたハイパーサーミア" 日本整形外科学会雑誌. 69-8. S1422- (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masao Akagi et al.: "Arti-Tumor Effects of Localized Hyperthermia On An Experimental Bone Tumor Using An Intramedullary Nail." International Journal of Hyperthermia. (in press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ikenaga, M., Ohura, K., Yamamuro, T., Kotoura, Y., Oka, M., and Kokubo, T.: "Localized hyperthermic treatment of experimental bone tumors with ferromagnetic ceramics." J Orthop Res. 11. 849-855 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ikenaga, M., Ohura, K., Kotoura, Y., Yamamuro, T., Nakamura, T., Oka, M., Hiraoka, M., and Abe, M.: "Hyperthermic treatment of canine tibia through RF inductive heating of an intramedullary nail : a new experimental approach to hyperthermia for metastatic bone tumors." Int J Hyperthermia. 10. 507-516 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Akagi et al.: "Localized hyperthermia for experimental metastatic bone tumor in rabbit tibia using a stainless intramedullary nail." J.Jpn.Orthop.Assoc. 69(8). S1422 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Akagi et al.: "Auti-Tumor Effects of Localized Hyperthermia On An Experimental Bone Tumor Using An Intramedullary Nail." International Journal of Hypertuermia. (in press).

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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