1996 Fiscal Year Final Research Report Summary
Development of a new strategy of hyperthermia for metastatic bone tumor
| Project/Area Number |
06557083
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 試験 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
TSUBOYAMA Tadao Kyoto University Lecturer Faculty of Medicine, 医学研究科, 講師 (90261221)
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| Co-Investigator(Kenkyū-buntansha) |
AKAGI Masao Kyoto University, Instructor Faculty of Medicine, 医学研究科, 助手 (00273441)
HIRAOKA Masahiro Kyoto University Profussor Faculty of Medicine, 医学研究科, 教授 (70173218)
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| Project Period (FY) |
1994 – 1996
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| Keywords | experimental bone tumor / hyperthermia / intramedullary nail / anti-tumor effects |
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| Research Abstract |
A new localized hyperthermia system for an experimental bone tumor in the rabbit tibia was developed. This system was composed of an induction coil, generator and a Kirschner wire, which was inserted into the medullary canal of the tibia as a heat-generating ferromagnetic implant. The metastatic bone tumor model was created by implantation of VX2 carcinoma in the medullary canal of the tibia diaphysis. Ten days after VX2 implantation, hyperthermia was induced for 50 min. Three weeks after the treatment, rabbits were sacrificed for histological and radiological evaluation. According to the semi-quantitative scoring system, anti-tumor effects of the single dose of hyperthermia was noted radiologically (<0.01) and histologically (<0.05) where the temperature was at a sufficient level to cause hyperthermia (>42.5ﾟC). This new heating method, which is relatively simple and clinically applicable, appears to be promising for the treatment of metastatic tumors of the long bone. The intramedullary nail of the alloy with low Curie point might make our hyperthermia system much safer and simpler for clinical use than that of stainless steel.
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[Publications] Ikenaga, M., Ohura, K., Yamamuro, T., Kotoura, Y., Oka, M., and Kokubo, T.: "Localized hyperthermic treatment of experimental bone tumors with ferromagnetic ceramics." J Orthop Res. 11. 849-855 (1993)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Ikenaga, M., Ohura, K., Kotoura, Y., Yamamuro, T., Nakamura, T., Oka, M., Hiraoka, M., and Abe, M.: "Hyperthermic treatment of canine tibia through RF inductive heating of an intramedullary nail : a new experimental approach to hyperthermia for metastatic bone tumors." Int J Hyperthermia. 10. 507-516 (1994)
Description
「研究成果報告書概要(欧文)」より
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