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1996 Fiscal Year Final Research Report Summary

Nonlinear analysis of the hemodynamics in the artificial heart animals as the aging acceleration model

Research Project

Project/Area Number 06558118
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section試験
Research Field Biomedical engineering/Biological material science
Research InstitutionTohoku University

Principal Investigator

YAMBE Tomoyuki  Instutite of Development, Aging & Cancer, Tohoku University, Assistant Prodessor, 加齢医学研究所, 講師 (70241578)

Co-Investigator(Kenkyū-buntansha) YOSHIZAWA Makoto  Faculty of Engineering Tohoku University, Associate Professor, 工学部, 助教授 (60166931)
MIURA Makoto  School of Medicine Tohoku University, Assistant Professor, 医学部附属病院, 講師 (50239191)
ABE Ken-ichi  Faculty of Engineering Tohoku University, Professor, 工学部, 教授 (70005403)
NITTA Shin-ichi  Institute of Development, Aging and Cancer, Tohoku University, Professor, 加齢医学研究所, 教授 (90101138)
Project Period (FY) 1994 – 1996
Keywordstotal artificial heart / chaos / fractal / nonlinear dynamics / aging / ventricular assist system / sympathetic nerve activity / automatic control
Research Abstract

The population composition of this country shifts to old age. Accordingly investigation of essence of "Aging" phenomenon is urgent business. Aging progresses in the whole of biological system. Thus, it is thought that it can't be elucidated by the reduction theory which was the mainstream in the past scientifis research. It is thought that application of the methodology of an analysis that established point of view with the whole system becomes necessary. In the animals with total artificial hearts, many pathophysiological changes such as Hypertension, elevation of central venous pressure, alteration of humoral factor, had been reported in some institutions.
So, an artificial heart animal was positioned as "Aging acceleration model". A change in the time series courve of hemodynamics of an artificial heart animal was observed with the chronic experiment using healthy adult goats. In this research, analysis by the nonlinear dynamics which paid attention to dynamic characteristic of the whole system was used.
Major research result was mentioned in the following.
1. Establishment of procedure of the biometrics that nonlinear mechanics was applied was tried.
2. Non-linear analysis of the hemodynamics with chronic experimental artificial heart animals. Comparison examination with hemodynamics by a natural heart was done.
3. Autonomic nerve activity recording was carried out in the artificial heart animals.
4.Long term survival experiment of artificial heart chronic experimental animals were carried out. The change that artificial heart control algorithrm gave to this physiology was observed. Consideration was added about the hemodynamics which was the optimum which controlled aging.

  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] T.Yambe,et al.: "Strange hemodynamic attractor parameter with 1/R total artificial heart sutomatic control algorithm" Int J Artif Organs. 19. 302-306 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Yambe,et al.: "Extraction of the 1/f fluctuation in hemodynamics of an artifcial heart" Artif Organs. 20. 777-782 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Yambe,et al.: "Spectral analysis of the hemodynamics during left ventricular assistance" Int J Artif Organs. 19. 367-371 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Yambe,et al.: "Fluctuations of the hemodynamic derivatives during left ventricular assistance using oscillated blood flow" Artif Organs. 20. 637-640 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Yambe,et al.: "Fractal analysis of the sympathetic discharges" IIAS Reports. 1996-01. 71-86 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Yambe,et al.: "Fractal circulation of the total artificial heart" IIAS Reports. 1996-01. 87-106 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Yambe, et al.: "Deterministic chaos in the hemodynamics of an artificial heart." ASAIO Journal. 41. 84-88 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yambe, et al.: "Strange hemodynamic attractor parameter with 1/R total artificial heart automatic control algorithm." Int J Artif Organs. 19. 302-306 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yambe, et al.: "Chaotic hemodynamics during oscillated blood flow." Artif Organs. 18. 633-637 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yambe, et al.: "Fluctuations in sympathetic nerve activity in animal without natural heartbeat." Artif Organs. 18. 775-780 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yambe, et al.: "Chaotic behavior of the hemodynamics with ventricular assist device." Int J Artif Organs. 18. 17-21 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yambe, et al.: "Fractal dimension analysis of the oscillated blood flow with vibrating flow pump." Artif Organs. 19. 729-733

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yambe, et al.: "Can the artificial heart make the circulation become fractal?" Int J Artif Organs. 18. 317-320 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yambe, et al.: "Fractal dimension analysis of the muscle sympathetic nerve activity." Pathophysiology. 2. 173-176 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yambe, et al.: "Extraction of the 1/f fluctuation in hemodynamics of an artificial heart." Artif Organs. 20. 777-782 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yambe, et al.: "Spectral analysis of the hemodynamics during left ventricular assistance." Int J Artif Organs. 19. 367-371 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Yambe, et al.: "Fluctuations of the hemodynamic derivatives during left ventricular assistance using oscillated blood flow." Artif Organs. 20. 637-640 (1996)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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