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1995 Fiscal Year Final Research Report Summary

PREPARATION OF NONTOROMBOGENICHEMODIALYZER AND ITS PRECLINICAL EVALUATION

Research Project

Project/Area Number 06558122
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionINSTITUTE FORR MEDICAL AND DENTAL ENGINEERING,TOKYO MEDICAL AND DENTAL UNIVERSITY

Principal Investigator

ISHIHARA Kazuhiko  Tokyo Medical and Dental University INSTITUTEFOR MEDICAL AND DENTAL ENGINEERING,DIVISION OF ORGANIC MATERIALS,ASSOCIATE PROFESSOR, 医用器材研究所, 助教授 (90193341)

Co-Investigator(Kenkyū-buntansha) YAMASHITA Yasuhiko  ASAHI CHEMICAL IDUSTRY CO., LTD.HOLLOW FIBERSDEVELOPMENT DEPARTMENT,HEAD OF THE, 繊維技術開発総部・HF技術事業部, 部長
AKIZAWA Tadao  SYOUWA UNIVERSITY SCHOOL OF MEDICINE,FUJIGAOKA HOSPITAL,DIVISION OF NEPHOLOGY,AS, 医学部・藤が丘病院腎臓内科, 助教授 (40102339)
WATANABE Akihiko  Tokyo Medical and Dental Universyty INSTITUTE FOR MEDICAL AND DENTAL ENGINEERING, 医用器材研究所, 助手 (30126263)
TANAKA Shinobu  DEPARTMENT OF ENGINEERING,YAMAGATA UNIVERSITY ASSOCIATE PROFESSOR, 工学部, 助教授 (40242218)
Project Period (FY) 1994 – 1995
KeywordsHemodialysis Membrane / Hemocompatibility / Nonthrombogenicity / Phospholipid Polymer / Platelet Adhesion / Protein Adsorption / Complement Activation / Artificail Kidney
Research Abstract

Hemocompatibility is one of the most important properties for homodialysis membranes. For improvement of the hemocompatibility on a cellulose dialysis membrane, modifications with new blood compatible phospholipid polymers were carried out. These methods incluuded a direct grafting of the phospholipid monomer on the membrane surface, coating the membrane surface with a water-soluble graft copolymer composed of a cellulose backbone and phospholipid polymer as a branch, and covalent bonding with a reactive phospholipid polymer on the membrane surface. These modified membranes could reduce protein adsorption, complement activation, and platelet adhesion on the surface without any adverse effects on the membrane perfomance.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] 岩崎泰彦,栗田公夫,田中志信,石原一彦,中林宣男: "リン脂質極性基を有するポリマーのex vivoにおける血液適合性の評価" 生体材料. 13. 62-70 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Ishihara、N.Nakabayashi: "Hemocompatible Cellulose Dialysis Membrane Madified with Phospholipid Polymer" Artifi・Organs. 19. 1215-1221 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 宮野龍之介,栗田公夫,石原一彦,渡辺昭彦,田中志信,中林宣男: "MPCポリマーによる血液透析膜の表面修飾" 東京医科歯科大学医用器材研究所報告. (印刷中). (1995)

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      「研究成果報告書概要(和文)」より
  • [Publications] K.Ishihara,H.Miyazaki,T.Kurasaki,N.Nakabayashi: "Improvement of Blood Compatihility of Cellulase Dialysis Membrane 3.Synthesis and Performance of Water Soluhle Cellulose Grafted with Phosphelipid Polymer" J. Biomed. Mater. Res.29. 181-188 (1995)

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      「研究成果報告書概要(和文)」より
  • [Publications] K.Ishihara,K.Fukumoto,H.Miyazaki,N.Nakabayashi: "Improvement of the Hemocompatibility on a Callulose Hollow Dialysis with a Novel Biomedical Polymer Having pnospholipid Polar Group" Artif・Organs. 18. 559-564 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 石原一彦,渡辺昭彦,中林宣男: "MPCポリマー修飾 抗血栓性セルロース中空糸膜" 人工臓器. 23. 654-659 (1994)

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      「研究成果報告書概要(和文)」より
  • [Publications] K.Ishihara,N.Nakabayashi: "Advaneed Bicmiterials in Biomedical Engineering and Drag Delivery Systems" Springer, 381 (1996)

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      「研究成果報告書概要(和文)」より
  • [Publications] K.ISHIHARA,A.WATANABE,N.NAKABAYASHI: "BLOOD COMPATIBLE CELLULOSE HOLLOW FIBERS MODIFIED WITH MPC POLYMER" JPN J ATRIFORGANS. 23 (3). 654-659 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.ISHIHARA,K.FUKOMOTO,H.MIYAZAKI,N.NAKABAYASHI: "IMPROVEMENT OF THE HEMOCOMPATIBILTY ON A CELLULOSE HOLLOW FIBERS WITH A NOVEL BIOMEDICAL POLYMER HAVING PHOSPHOLIPID POLAR GROUP" ARTIFI ORGANS. 18 (8). 559-564 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.ISHIHARA,H.MIYAZAKI,T.KUROSAKI,N.NAKABAYASHI: "IMPROVEMENT OF BLOOD COMPATIBILITY OF CELLULOSEDIALYSIS MEMBRANE3. SYNTHESIS AND PERFORMANCEOD WATER-SOLUBLECELLULOSE GRAFTED WITH PHOSPHOLIPID POLYMER AS COATING MATERIALSON CELLULOSE DIALYSIS MEMBRANE" J BIOMED MATER RES. 29 (2). 181-188 (1995)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Y.IWASAKI,K.KURITA,S.TANAKA,K.ISHIHARA,N.NAKABAYASHI: "EX VIVOEVALUATION OF BLOOD COMPATIBILITY OF PHOSPHOLIPID POLYMERS" J J SOC BIOMAT. 13 (2). 62-70 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.ISHIHARA,N.NAKABAYASHI: "HEMOCOMPATIBLE CELLULOSEDIALYSIS MEMBRANE MODIFIED WITH PHOSPHOLIPID POLYMER" ARTIFI ORGANS. 19 (12). 1215-1221 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.MIYANO,K.KURITA,A.WATANABE,S.TANAKA,K.ISHIHARA,N.NAKABAYASHI: "SURFACEMODIFICATION OF CELLULOSE HEMODIALYSIS MEMBRANE WITH MPC POLYMER" IYO KIZAIKENKYUSYO HOUKOKU. 29 (INPRESS). (1995)

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  • [Publications] K.ISHIHARA,N.NAKABAYASHI: "HEMOCOMPATIBLE CELLULOSEDIALYSIS MEMBRANEMODIFIED WITH PHOSPHOLIPID POLYMER" ADVENCED BIOMATERIALSIN BIOMEDICAL ENGINEERING AND DRUG DELIVERY SYSTEMS SPRINGER. 213-214 (1996)

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Published: 1997-03-04  

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