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1995 Fiscal Year Final Research Report Summary

Development of a new noninvasive targeting and high-speed thrombolytic method combined with drug and ultrasound for the embolic artery.

Research Project

Project/Area Number 06558127
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionThe Jikei University School of Medixine

Principal Investigator

FURUHATA Hiroshi  The Jikei Univ.Schl.of Med., Med.Dept.Assoc.Prof., 医学部, 助教授 (70056985)

Co-Investigator(Kenkyū-buntansha) SUZUKI Yoshinori  Toshiba Research & Development Center, Chief Research, 研究開発センター, 主任研究員
IIJIMA Shiro  Kyoritsu Coll.of Phrm., Phrm.Dept.Assistant, 薬学部, 助手 (30222798)
KIMURA Miyako  Kyoritsu Coll.of Phrm., Phrm.Dept.Assoc.Prof., 薬学部, 助教授 (20050734)
HARA Masatada  The Jikei Univ.Schl.of Med., Med.Dept.Lecturer, 医学部, 講師 (60147345)
Project Period (FY) 1994 – 1995
Keywordsultrasound / thrombolysis / plasminogen activator / thrombus / FDP / recanalization / coronary artery / ischemic disease
Research Abstract

Foundamental and experimental studies of a new thrombolytic method with ultrasound have been performed for the practical use. This method features the early recanalization and the targeting to the embolus.
Thrombolytic drug used for this study was a tissue typed plasminogen activator (rt-PA) 2mug/ml in in-vitro experiment and 1mg/kg venous injection in animal experiment. The ultrasound was contineous wave at 100KHz-1.2MHz in frequency and 0-0.75W/cm^2 in power, and 30 min. irradiation. We obtained the following results.
(1) Ultrasonic frequency characteristics : It was verified from an in vitro experiment that the thrombolytic effect was particularly enhanced be the ultrasonic irradiation which frequency was ranged from 100KHz to 300KHz. This result was derived from the evaluation of the decreasing ratio of clot weight and the quantity of FDP-DD in the sloution.
(2) Ultrasonic power tendency : The enhancement of thrombolysis was linearly related to the increase of ultrasonic irradiation p … More ower.
(3) Mechanism of the enhancement of thrombolysis : The residual solution of thrombolysis was examined by the electro fluence. The spectrum pattern of the solution was the same between the combined new method and the administration of rt-PA alone. The spectral concentration was higher in a new combined method.
(4) High-speed recanalization in animal experiment : The embolus was formed in the left anterior decednding coronary artery as a model for the acute myocardiac infarction. In comparison with a new combined method and rt-PA alone, the recanalization time by a new method was 15 min as the mean, which was one third of the recanalization time by rt-PA alone.
(5) Evaluation of safety hazard : As the result of the pathological evaluation of the skin, the chest wall and the myocardium, there was no damage in those tissues for the ultrasonic power level at 0.75 W/cm^2.
(6) Aspect to the clinical use : This new combined thrombolytic method have a quite high possibililty of the clinical application, as the first choice of the thrapeutic technique for the ischemic desease with emboli.
It was concluded that this new thrombolytic method had high possibility for the early recanalization of the ischemic desease with emboli. Less

  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] 原正忠 他11名: "標的型超音波併用血栓溶解療法のパワー依存性." 医用電子と生体工学. 33特. 499- (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 古幡博 他9名: "標的型無浸襲超音波併用血栓溶解療法の開発." 医用電子と生体工学. 32特. 469- (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 原正忠 他9名: "経胸的超音波照射併用による血栓溶解療法のAMI治療応用への可能性の検討" Jpn Circ J. abstracts. 58Suppl. 1. 95- (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Furuhata,Hiroshi.: "Early Trombolytic Method Combining Trombolytic Drug and Ultrasonic Irradiation." Ultrasound in medicine and biollogy. 20Suppl. S17- (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Furuhata,Hiroshi,Kudo,Sumihiko Hamano,Kenji,Yoshizawa,Sunao Hara,Masatada,Okamura,Tstsuo Takatsu Akihiro: "Early Recanalization method Enhancing Thrombolytic Drug Effect with Transcutaneous Ultrasonic Irradiation." Stroke. 25. 741- (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hara, Masatada, et al.: "Power Response of the Target Thrombolysis Method with Ultrasonic Irradiation." BME.33 Sppl.499 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Furuhata, Hiroshi.: "Early Trombolytic Method Combining Trombolytic Drug and Ultrasonic Irradiation." Ultrasound in medicine and biology. 20 Suppl.S17 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Furuhata, Hiroshi, et al.: "Target Thrombolytic Method Combining Thrombolysis Drugs and Noninvasive Ultrasonic Irradiation." BME.32 Supl.469 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Furuhata, Hiroshi, et al.: "Early Recanalization method Enhancing Thrombolytic Drug Effect with Transcutaneous Ultrasonic Irradiation." Stroke.25. 741 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hara, Masatada, et al.: "Study on the Possibility of Transthorathic Thrombolytic Method Combined with Drug and Ultrasonic Irradiation for the AMI Therapy." Jpn Circ J.58 Suppl 1.(1994)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1997-03-04  

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