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1995 Fiscal Year Final Research Report Summary

New materials for artificial joint -Development of hydroxyapatite containing glass coated titanium composite-

Research Project

Project/Area Number 06559008
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 広領域
Research InstitutionNagoya University

Principal Investigator

IWATA Hisashi  Nagoya University School of Medicine, Professor, 医学部, 教授 (90023796)

Co-Investigator(Kenkyū-buntansha) ITO Haruo  Tokyo Kouseinenkin Hospital
BAN Seigi  Aichi-Gakuin Unibersity school of Dentistry, Lecturer, 歯学部, 講師 (10159105)
MARUNO Shigeo  Nagoya Institute of Technology, Professor, 工学部, 教授 (60024204)
ISHIGURO Naoki  Nagoya University School of Medicine, Lecturer, 医学部, 講師 (20212871)
HASEGAWA Yukiharu  Nagoya University School of Medicine, Lecturer, 医学部, 講師 (50208500)
Project Period (FY) 1994 – 1995
KeywordsArtificial joint / Hydroxyapatite / Titanium coposite / Glass / Bone-apatite interface / Bone formation / Bone absorption
Research Abstract

It is well known that the hydroxyapatite (HA) is a bioactive ceramic having excellent biocompatibility with the body environment, and that pure titanium and titanium alloy such as Ti-6Al-4V with sufficient mechanical strength are suitable metals exhibiting good biological stability and affinity. In recent years, paticular attention has been drawn to the use of HA-coated implants for hip prostheses and a dental implants in which HA layr is coated on the surface of titanium substrate by plasma spraying, sputtering, hot pressing, and laser deposition, etc. Among these techniques, plasma spraying is a method commonly used in commercial products. However'there is a problem of change of chemical composition and structure due to the themal decomposition of HA under high temperature in plasma, and the HA coating layr with more than 50 mum in thickness behave like a brittle ceramic and leads to the peeling. Furthemore, the large difference in the linear thermal expansion coeffcient between the … More HA coating layr and the titanium or Ti-6Al-4V substrate can cause fatigue failure under tensile load.
From the point of view, a HA containing glass coated titanium composite (HA-G-Ti composite) was developed with newly prepared glass and conventional enameling technique without using high temperatures such as plasma spraying. This composite consists of a substrate coated with a HA containing glass layr, wherein the layr comprises a continuous glass phase with dispersed HA particles and the surface is prepared in a roughened state. It has been found that the HA-G-Ti composite provides both bioactivity potential due to the HA and the mechanical strength of titanium, and the composites are useful for biocompatible composite materials which are especially suitable for implant applications. It is demonstrated that the physical properties of the HA containing glass with different concentration of HA are suitable to constitute the HA-G-Ti composite for bioactive implant and to make an excellent adhesion between the HA containing glass and the substrate. Less

  • Research Products

    (33 results)

All Other

All Publications (33 results)

  • [Publications] Yuan Rong,Keiji Sato,Hideshi Sugiura,Takayasu Ito,Shinij Sakano,Hisashi Iwata,and Koji Kimata.: "Effect of Elevated Temperature on Experimental Swarm Rat Chondrosarcoma" Clin.Orthop.311. 227-231 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ming Zhao,M.Yoneda,Y.Ohashi,S.Kurono,H.Iwata,Y.Ohnuki and K.Kimata.: "Evidence for the Covalent Binding of SHAP,Heavy Chains of Inter-α-Trypsin Inhibitor,to Hyaluronan." J.Biological Chem.270. 26657-26663 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Keiko Yamamura,Hisashi Iwata,Takashi Osada,Kohji Yano,Toshihisa Yotsuyanagi and Toshitaka Nabeshima.: "Prevention of bone Ioss by percutaneous estradiol implants in ovariectomized rats." J.Biomedical Materials Research. 29. 1249-1253 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takayasu Ito,S.Sakano,K.Sato,H.Sugiura,H.Iwata,Y.Murata and H.Seo.: "Sensitivity of Osteoinductive Activity of Demineralized and Defatted Rat Femur to Temperature and Duration of Heating." Crin.Orthop.316. 267-275 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Yamamura,H.Iwata,T.Osada,T.Yotsuyanagi and T.Nabeshima.: "Antitumor Effects and Distribution of Adriamycin Incorporated into Hydroxyapatite Implants in a Cancer Rat Model Bearing Swarm Rat Chondrosarcoma." Jpn.J.Pharmacol.66. 433-438 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Ban.Maruno,H.Iwata and H.Itoh.: "Calcium phosphate precipitation on the surface of HA-G-Ti composite under physiologic conditions." J.Biomed.Mater.Res.28. 65-71 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Iwata,S.Ono,K.Sato,T.Sato and M.Kawamura.: "Bone Morphogenetic Protein-Induced Muscle-and Synovium-Derived Cartilage Differentiation in vitro." Clin.Orthop.296. 295-300 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Sakano,Y.Murata,T.Miura,H.Iwata,K.Sato,N.Matsui and H.Seo.: "Collagen and Alkaline Phosphatase Gene Expression During Bone Morphogenetic Protein (BMP) -Induced Cartilage and Bone Differentiation." Clin.Orthop.292. 337-344 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Ishikawa,H.Itoh,S.Maruno,H.Iwata and S.Ban.: "Effect of Hydroxyapatite Containing Glass Coating on the Bonding between Bone and Titanium Implants." Clin.Mater.14. 277-285 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Iwata S.Torii,Y.Hasegawa,H.Itoh,M.Mizuno,E.Genda and Y.Kataoka.: "Indications and Results of Vascularized Pedicle Iliac Bone Graft in Avascular Necrosis of the Femoral Head." Clin.Orthop.295. 281-288 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Katoh,K.Sato,M.Kawamura,H.Iwata and T.Miura.: "Osteogenesisi in Sintered Bone Combined With Bovine Bone Morphogenetic Protein." Clin.Orthop.287. 266-275 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Iwata.: "Pharmacologic and Clinical Aspects of Intraarticular Injection of Hyaluronate." Clin.Orthop.289. 285-291 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Nishida,S.Kondo,Y.Miura,H.Iwata and K.Isobe.: "Survival of Syngeneic and Allogeneic Grafted Bone in Transgenic Mice." Biochem.Biophys.Res,Commun.196. 1081-1085 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Yamamura,H.Iwata,and T.Yotsuyanagai.: "Synthesis of antibiotic-loaded hydroxyapatite beads and in vitro drug release testing." J.Biomed.Mater.Res.26. 1053-1064 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Iwata,K.Yamamura and X.Z.Zhao.: "The effect of Egg Phosphatidylcholine on Antibiotics Retention and Release from Hydroxyapatite." J.Appl.Biomater.3. 269-273 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岩田 久,山田健志,伊藤晴夫,丸野重雄: "ハイドロキシアパタイト含有ガラスコーティングチタン複合体" Orthopaedics. 8. 29-40 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岩田 久,伊藤晴夫,石川知志,山田健志,丸野重雄: "ハイドロキシアパタイト含有ガラスチタン複合体の開発と人工関節への応用" Orthopaedics. 8. 13-19 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岩田 久,丸野重雄,伊藤晴夫,石川知志: "人工股関節材料としてのハイドロキシアパタイト含有ガラスチタン複合体" 現代医学. 42. 55-62 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yuan Rong, Keiji Sato: "Hideshi Sugiura, Takayasu Ito, Shinji Sakano, Hisashi Iwata, and Koji Kimata. Effect of Elevated Temperature on Experimental Swarm Rat Chondrosarcoma" Clin.Orthop.311. 227-231 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ming Zhao, Masahiko Yoneda, Yoko Ohashi, Sadamu Kurono, Hisashi Iwata, Youji Ohnuki and Koji Kimata: "Evidence for the Covalent Binding of SHAP,Heavy Chains of Inter-alpha-Trypsin Inhibitor, to Hyaluronan." J.Biological Chem.270. 26657-26663 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Keiko Yamamura, Hisashi Iwata, Takashi Osada, Kohji Yano, Toshihisa Yotsuyanagi and Toshitaka Nabeshima: "Prevention of bone loss by percutaneous estradiol implants in ovariectomized rats." J.Biomedical Materials Research. 29. 1249-1253 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takayasu Ito, Shinji Sakano, Keiji Sato, Hideshi Sugiura, Hisashi Iwata, Yoshiharu Murata and Hisao Seo: "Sensitivity of Osteoinductive Activity of Demineralized and Defatted Rat Femur to Temperature and Duration of Heating." Crin.Orthop.316. 267-275 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Yamamura, H.Iwata, T.Osada, T.Yotsuyanagi and T.Nabeshima.: "Antitumor Effects and Distribution of Adriamycin Incorporated into Hydroxyapatite Implants in a Cancer Rat Model Bearing Swarm Rat Chondrosarcoma." Jpn.J.Pharmacol. 66. 433-438 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Ban, S.Maruno, H.Iwata and H.Itoh: "Calcium phosphate precipitation on the surface of HA-G-Ti composite under physiologic conditions." J.Biomed.Mater.Res.28. 65-71 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Ishikawa, H.Itoh, S.Maruno, H.Iwata and S.Ban.: "Effect of Hydroxyapatite Containing Glass Coating on the Bonding between Bone and Titanium Implants." Clin.Mater.14. 277-285 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Iwata, S.Ono, K.Sato, T.Sato and M.Kawamura: "Bone Morphogenetic Protein-Induced Muscle-and Synovium-Derived Cartilage Differentiation in vitro." Clin.Orthop. 296. 295-300 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Sakano, Y.Murata, T.Miura, H.Iwata, K.Sato, N.Matsui and H.Seo.: "Collagen and Alkaline Phosphatase Gene Expression During Bone Morphogenetic Protein (BMP)- Induced Cartilage and Bone Differentiation." Clin.Orthop. 292. 337-344 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Iwata, S.Torii, Y.Hasegawa, H.Itoh, M.Mizuno, E.Genda and Y.Kataoka.: "Indications and Results of Vascularized Pedicle Iliac Bone Graft in Avascular Necrosis of the Femoral Head." Clin.Orthop. 295. 281-288 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Katoh, K.Sato, M.Kawamura, H.Iwata and T.Miura.: "Osteogenesisi in Sintered Bone Combined With Bovine Bone Morphogenetic Protein." Clin.Orthop. 287. 266-275 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Iwata: "Pharmacologic and Clinical Aspects of Intraarticular Injection of Hyaluronate." Clin.Orthop. 289. 285-291 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Nishida, S.Kondo, Y.Miura, H.Iwata and K.Isobe: "Survival of Syngeneic and Allogeneic Grafted Bone in Transgenic Mice." Biochem.Biophys.Res.Commun. 196. 1081-1085 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Yamamura, H.Iwata, and T.Yotsuyanagai.: "Synthesis of antibiotic-loaded hydroxyapatite beads and in vitro drug release testing." J.Biomed.Mater.Res. 26. 1053-1064 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Iwata, K.Yamamura and X.Z.Zhao: "The effect of Egg Phosphatidylcholine on Antibiotics Retention and Release from Hydroxyapatite." J.Appl.Biomater.3. 269-273 (1992)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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