1996 Fiscal Year Final Research Report Summary
Roles of Thyroid and Adrenal glands in the regulation of hypothalamo-hypophysial-ovarian axis in the rat.
| Project/Area Number |
06660375
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
TAYA Kazuyoshi Tokyo University of Agriculture and Technology, Faculty of Agriculture, Professor, 農学部, 教授 (60092491)
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| Project Period (FY) |
1994 – 1996
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| Keywords | Rat / stress / Thyroid gland / Adrenal gland / Ovary / Prolactin / ACTH / Gonadotropin |
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| Research Abstract |
The functional relationship between thyroid, adrenal and gonadal hormones was investigated using adult male rats. Hypothyroidism was produced by the administration of 4-methy1-2-thiouracil (thiouracil) in the drinking water for 2 weeks. Plasma concentrations of TSH dramatically increased, whereas plasma concentrations of tri-iodothyronine and thyroxine decreased in thiouracil-treated rats as compared with euthyroid rats.
Hypothyroidism increased basal levels of plasma ACTH and pituitary content of ACTH.The pituitary responsiveness to CRH for ACTH release markedly increased, whereas the adrenal responsiveness to ACTH for corticosterone release decreased. These results indicated that hypothyroidism causes adrenal dysfunction in adult male rats. Pituitary contents of LH and prolactin decreased in hypothyroid rats as compared with euthyroid rats. In addition, hypothyroidism lowered pituitary LH responsiveness to LHRH.
Testicular responsiveness to human chorionic gonadotrophin for testosterone release, however, was not different between euthyroid and hypothyroid animals. These results indicated that hypothyroidism causes adrenal dysfunction and results in hypersecretion of ACTH from the pituitary gland. Adrenal dysfunction may contribute to the inhibition of LHRH secretion from the hypothalamus, possibly mediated by excess CRH.
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[Publications] Konishi, M., Aoyagi.Y., Takedomi, T., Itakura, H., Itoh, T., Yazawa, S., Kishi, H., Taya, K., Watanabe, G.and Kanegawa, H.: "Effect of active immunization of cattle against inhibin on ovarian follicular development and ultrasound-guided transvaginal follicular aspiration." Theriogenology. 46. 33-43 (1996)
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[Publications] Kishi, H., Okada, T., Otsuka, M., Watanabe, G., Taya, K.and Sasamoto, S.: "Induction of superovulation by immunoneutralization of endogenous inhibin through the increase of FSH in the cyclic golden hamster." Journal of Endocrinology. 151. 65-75 (1996)
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[Publications] Nambo, Y., Nagata, S., Oikawa, M., Yoshihara, T., Tsunoda, N., Kohsaka, T., Taniyama, H., Watanabe, G.and Taya, K.: "High concentrations of immunoreactive inhibin in the plasma of mare's and Retal gonads during the second half of pregnancy." Reproduction Fertility and Development. 8. 1137-1145 (1996)
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